Different roles of cilia in different segmentations of reproductive tract

Huang, Liyang; Ma, Mingyu; Huang, Donghui

doi:10.1007/s10815-022-02524-x

Cited by 1 publication

(2 citation statements)

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“…Within the male reproductive system, the epididymis, mirroring the structural composition of the fallopian tube with segments including the initial segment, head, body, and tail, possesses the capacity for sperm transportation ( Girardet et al, 2019 ; Huang et al, 2022 ). Research findings have underscored the aggregation of primary cilia within the testes, epididymis, and prostate of mice, where they exert a pivotal role in sperm transport ( Zhang et al, 2009 ; Ou et al, 2014 ; Bernet et al, 2018 ).…”

Section: The Role Of Primary Cilia In Reproductive Physiologymentioning

confidence: 99%

“…Moreover, deficiency of IFT25 in murine male germ cells precipitates a reduction in sperm count and impairs sperm morphology, characterized by rounded heads and truncated, curved tails ( Huang et al, 2020 ). Primary cilia possess the capability to perceive and modulate the surrounding sperm environment and sperm functionality across various developmental stages of the male reproductive system via specialized mechanisms (diversified extension) ( Huang et al, 2022 ). Literature documentation has elucidated that primary cilia located in immature testicular cells facilitate the formation of testicular tubules via the Hedgehog (Hh) signaling pathway ( Dores et al, 2017 ; Sakib et al, 2019 ).…”

Section: The Role Of Primary Cilia In Reproductive Physiologymentioning

confidence: 99%

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Structure, function, and research progress of primary cilia in reproductive physiology and reproductive diseases

Long,

Chen,

Xiao

et al. 2024

Front. Cell Dev. Biol.

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Primary cilia, serving as the central hub for cellular signal transduction, possess the remarkable ability to translate diverse extracellular signals, both chemical and mechanical, into intracellular responses. Their ubiquitous presence in the reproductive system underscores their pivotal roles in various cellular processes including development, differentiation, and migration. Emerging evidence suggests primary cilia as key players in reproductive physiology and associated pathologies. Notably, primary cilia have been identified in granulosa cells within mouse ovaries and uterine stromal cells, and perturbations in their structure and function have been implicated in a spectrum of reproductive dysfunctions and ciliary-related diseases. Furthermore, disruptions in primary cilia-mediated signal transduction pathways under pathological conditions exacerbate the onset and progression of reproductive disorders. This review provides a comprehensive overview of current research progress on primary cilia and their associated signaling pathways in reproductive physiology and diseases, with the aim of furnishing theoretical groundwork for the prevention and management of primary cilia-related structural and functional abnormalities contributing to reproductive system pathologies.

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