2011
DOI: 10.1111/j.1476-5381.2011.01211.x
|View full text |Cite
|
Sign up to set email alerts
|

Different sensitivities of rat skeletal muscles and brain to novel anti‐cholinesterase agents, alkylammonium derivatives of 6‐methyluracil (ADEMS)

Abstract: The rat respiratory muscle diaphragm has markedly lower sensitivity than the locomotor muscle extensor digitorum longus (EDL) to the new acetylcholinesterase (AChE) inhibitors, alkylammonium derivatives of 6-methyluracil (ADEMS). This study evaluated several possible reasons for differing sensitivity between the diaphragm and limb muscles and between the muscles and the brain. EXPERIMENTAL APPROACHIncreased amplitude and prolonged decay time of miniature endplate currents were used to assess anti-cholinesteras… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
5
0

Year Published

2012
2012
2020
2020

Publication Types

Select...
8
2

Relationship

0
10

Authors

Journals

citations
Cited by 16 publications
(5 citation statements)
references
References 56 publications
0
5
0
Order By: Relevance
“…The recorded responses were filtered (bandpass 0.03–10 kHz) and digitized at 10–20 μs intervals. The mEPCs were analysed using an original computer program designed to determine the amplitude and e‐fold decay time constant (Petrov et al ., ). The decay time constant (τ) was estimated as the time interval between 0.8 and 0.367 of the mEPC amplitude (e‐fold decrease).…”
Section: Methodsmentioning
confidence: 97%
“…The recorded responses were filtered (bandpass 0.03–10 kHz) and digitized at 10–20 μs intervals. The mEPCs were analysed using an original computer program designed to determine the amplitude and e‐fold decay time constant (Petrov et al ., ). The decay time constant (τ) was estimated as the time interval between 0.8 and 0.367 of the mEPC amplitude (e‐fold decrease).…”
Section: Methodsmentioning
confidence: 97%
“…To confirm this hypothesis, Krajewska and Shugar initiated investigation of the spatial organization of the complex of uridine phosphorylase from the pathogenic microorganism V. cholerae of biotype eltor in serogroup O1 (VchUPh) with 6-methyluracil (6-MU). 6-MU is used to stimulate immunodefence, as an anabolic drug and as an adjuvant in antibiotic therapy (Chadaev & Klimiashvili, 2003;el-On & Weinrauch, 1990;Ganzhii, 2002;Gerasimenko et al, 2002;Petrov et al, 2011;Taran & Shishkina, 1993).…”
Section: Introductionmentioning
confidence: 99%
“…In this case, the sequences of inhibited synaptic AChE are: (i) more ACh molecules reach the postsynaptic membrane without being catalytically hydrolyzed by AChE during their diffusion across the synaptic cleft, and therefore, more AChRs are activated; (ii) because of prolonged lifespan in synaptic cleft, ACh molecules activate AChRs sustainably. Electrophysiological recordings show that prolonged lifetime of ACh in synaptic cleft due to AChE inactivation results in the increase of amplitude and duration of mEPPs ( Katz and Miledi, 1975 ; Petrov et al, 2006 , 2009 , 2011 ). This fact is in agreement with idea that the main function of AChE in synaptic cleft is to control the duration of ACh action on postsynaptic AChRs.…”
Section: Cholinesterase Inhibition and Autoregulation Of Acetylcholinmentioning
confidence: 99%