Different spexin level in obese vs normal weight children and its relationship with obesity related risk factors

Behrooz, Maryam; Vaghef-Mehrabany, Elnaz; Ostadrahimi, Alireza

doi:10.1016/j.numecd.2019.11.008

Cited by 40 publications

(29 citation statements)

References 52 publications

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“…58 Behrooz et al showed that some serum inflammatory markers such as IL-10, IL-1b, and hs-CRP were closely associated with spexin levels in obese children. 59 Furthermore, Gambaro et al 24 observed that the inflammatory markers IL-6, Our results revealed that spexin treatment exerts only reduced effects on urine creatinine in renal function tests. In addition, the kidney tissue in the CKFþS group showed a macroscopic appearance and pathological changes similar to those of the CKF group.…”

Section: Discussionmentioning

confidence: 48%

Inflammatory response and matrix metalloproteinases in chronic kidney failure: Modulation by adropin and spexin

Yazgan

Avcı

Memi

et al. 2021

Exp Biol Med (Maywood)

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Chronic kidney disease is a major global public health problem. The peptide hormones adropin and spexin modulate many physiological functions such as energy balance and glucose, lipid and protein metabolism. However, it is unclear whether these peptides may exert effects on renal damage, tissue remodeling, and inflammatory conditions. In view of the limited information, we aimed to investigate the effect of adropin and spexin on matrix metalloproteinase and inflammatory response genes a rat model of adenine-induced chronic kidney failure. Chronic kidney failure was induced in rats by administering adenine hemisulfate. Renal function was determined in an autoanalyzer. Histopathological modifications were assessed by H&E staining. mRNA expression levels of ALOX 15, COX 1, COX 2, IL-1β, IL-10, IL-17A, IL-18 IL-21, IL-33, KIM-1, MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, NGAL, TGFβ1, TIMP-1, and TNFα in kidney tissue were measured by qPCR. Our results showed an increase of 24-h urine volume, serum creatinine, BUN, and urine protein levels in group with adenine-induced CKF. Adropin and spexin treatments decreased urine protein and 24-h urine volume. Renal damage, TIMP-1, IL-33, and MMP-2 increased after CKF induction, while COX 1, MMP-9, and MMP-13 levels were significantly reduced. Furthermore, KIM-1, TIMP-1, IL-33, and MMP-2 were downregulated by spexin treatment. Renal damage, NGAL, TIMP-1 IL-17A, IL-33, MMP-2, and MMP-3 decreased after adropin treatment, while MMP-13 levels were upregulated. Treatment with adropin+spexin decreased KIM-1, NGAL, TIMP-1, IL-1β, IL-17A, IL-18, IL-33, ALOX 15, COX 1, COX 2, TGFβ1, TNFα, MMP-2, MMP-3, and MMP-7, but increased MMP-13 levels. Our findings revealed that inflammatory response and MMP genes were modulated by adropin and spexin. These peptides may have protective effects on inflammation and chronic kidney damage progression.

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Section: Discussionmentioning

confidence: 48%

Inflammatory response and matrix metalloproteinases in chronic kidney failure: Modulation by adropin and spexin

Yazgan

Avcı

Memi

et al. 2021

Exp Biol Med (Maywood)

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“…Spexin, a neuropeptide with regulatory function in obesity, is suggested to have a potential role in childhood obesity and its associated metabolic disorders. (13,(36)(37)(38)(39)(40) In our study, medians of spexin levels were significantly lower in OB, MO and MetS groups vs N-BMI children.…”

Section: Discussionsupporting

confidence: 44%

“…It modulates depression, anxiety and blood pressure. (13)(14)(15) Adipolin exhibits beneficial effects on insulin sensitivity like spexin. The other name of adipolin is C1q/TNF-related protein 12 (CTRP12).…”

Section: Introductionmentioning

confidence: 99%

Morbi̇d Obez Ve Metaboli̇k Sendromlu Çocuklarda Yeni̇ Nesi̇l Enflamatuvar Beli̇rteçleri̇n Değerlendi̇ri̇lmesi̇

Donma¹,

Erselcan²,

Yılmaz³

et al. 2020

Namık Kemal Tıp Dergisi

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Technological advancements, unbalanced nutrition, sedentary life style, are important factors in obesity. Obesity-inflammation relationis beingexamined. In this study, the relationships among new generation inflammatory markers in children with normal body mass index (C) as well as obese (OB), morbid obese (MO) children and those with metabolic syndrome (MetS) were investigated. Materials and Methods: A total of 172 children participated in the study.Group 1 comprised children with normal body-mass index (control group) (C). Obese (OB) children were in Group 2, MO children constituted Group 3 and Group 4 included MO children with MetS. The number of cases were 37, 34, 51 and 50 in groups 1, 2, 3 and 4, respectively. Anthropometric measurements were recorded. Serum spexin, adropin, adipolipin, fibroblast growth factor-21 and fetuin-A levels were determined. Statistical analyses were performed. Result: Spexin and adipolin levels were significantly lower in obese groups than C group (p<0.05). Although adropin and FGF-21 levels did not differ significantly between groups, levels were lower in OB, MO, and MetS groups than C group.There were no significant differences among fetuin-A levels of the groups. Correlations between spexin and adipolin were the highest. These cytokines were negatively correlated with obesity parameters. The correlations between these cytokines were weakened from C group to MetS group. Conclusion: Decreasing spexin and adipolin levels in accordance with increasing obesity degrees and weakening of the correlation between these cytokines in MO group compared to C group may be helpful during the further investigation of obesity.

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“…They showed that the SPX gene is one of the most downregulated genes in adipose tissue during obesity and that SPX administration reduced food intake in mice [ 159 ]. Other research has also shown that the SPX concentration in serum is downregulated during obesity and diabetes [ 99 , 160 , 161 , 162 ]. In isolated adipocytes and the 3T3-L1 cells SPX had no effect on the proliferation or cell viability; however, it was able to regulate adipogenesis, lipolysis, lipogenesis and glucose uptake [ 154 , 159 , 163 ].…”

Section: Spexinmentioning

confidence: 99%

The Role of Peptide Hormones Discovered in the 21st Century in the Regulation of Adipose Tissue Functions

Kołodziejski

Pruszyńska‐Oszmałek

Wojciechowicz

et al. 2021

Genes

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Peptide hormones play a prominent role in controlling energy homeostasis and metabolism. They have been implicated in controlling appetite, the function of the gastrointestinal and cardiovascular systems, energy expenditure, and reproduction. Furthermore, there is growing evidence indicating that peptide hormones and their receptors contribute to energy homeostasis regulation by interacting with white and brown adipose tissue. In this article, we review and discuss the literature addressing the role of selected peptide hormones discovered in the 21st century (adropin, apelin, elabela, irisin, kisspeptin, MOTS-c, phoenixin, spexin, and neuropeptides B and W) in controlling white and brown adipogenesis. Furthermore, we elaborate how these hormones control adipose tissue functions in vitro and in vivo.

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Different spexin level in obese vs normal weight children and its relationship with obesity related risk factors

Cited by 40 publications

References 52 publications

Inflammatory response and matrix metalloproteinases in chronic kidney failure: Modulation by adropin and spexin

Inflammatory response and matrix metalloproteinases in chronic kidney failure: Modulation by adropin and spexin

Morbi̇d Obez Ve Metaboli̇k Sendromlu Çocuklarda Yeni̇ Nesi̇l Enflamatuvar Beli̇rteçleri̇n Değerlendi̇ri̇lmesi̇

The Role of Peptide Hormones Discovered in the 21st Century in the Regulation of Adipose Tissue Functions

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