Abstract:Malignant cells build up a protective scaffold in form of fibrin meshwork surrounding the tumor cells and provide an extracellular matrix (ECM) consisting of proteoglycans, collagens, glycoproteins, and glycosaminoglycans. Simultaneously, they produce stem cells in an early cancer stadium, which gain the energy and oxygen for their metabolism from the anaerobic glycolysis and are therefore independent of arterial supply. Many publications show that heparins have a wide variety of efficiencies to tumor metaboli… Show more
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