Different Survival Benefits of Chinese Medicine for Pancreatic Cancer: How to Choose?

Li, Meng; Wang, Miaomiao; Guo, X P; Wu, Chaoyong; Li, Daorui; Zhang, Xing; Peitong, Zhang

doi:10.1007/s11655-017-2971-1

Cited by 10 publications

(7 citation statements)

References 33 publications

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“…Both decoctions have been found to increase the overall survival of pancreatic tumor patients. In a study ( Li M et al, 2018 ), 174 patients were allocated to groups that received comprehensive medicine (IM) or TCM, according to whether they received treatment with Western medicine. The patients were treated with Gexia Zhuyu Decoction or Liujun Ermu Decoction, according to syndrome differentiation, twice a day for at least 2 months, after which their overall survival (OS) was compared.…”

Section: Treatment With Chinese Herbsmentioning

confidence: 99%

Advances in the treatment of pancreatic cancer with traditional Chinese medicine

Zhang,

Xu,

et al. 2023

Front. Pharmacol.

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Pancreatic cancer is a common malignancy of the digestive system. With a high degree of malignancy and poor prognosis, it is called the “king of cancers.” Currently, Western medicine treats pancreatic cancer mainly by surgical resection, radiotherapy, and chemotherapy. However, the curative effect is not satisfactory. The application of Traditional Chinese Medicine (TCM) in the treatment of pancreatic cancer has many advantages and is becoming an important facet of comprehensive clinical treatment. In this paper, we review current therapeutic approaches for pancreatic cancer. We also review the protective effects shown by TCM in different models and discuss the potential molecular mechanisms of these.

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Section: Treatment With Chinese Herbsmentioning

confidence: 99%

Advances in the treatment of pancreatic cancer with traditional Chinese medicine

Zhang,

Xu,

et al. 2023

Front. Pharmacol.

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“…In addition to the orthotopic model established using human PC cell lines, there are some new findings in PDOX models. Traditional Chinese medicine has been used as an important adjunct to cancer treatment [ 64 ]. The traditional Chinese medicine Brucea javanica can induce apoptosis of PC cells in vitro [ 65 ].…”

Section: Preclinical Application Of Pc Modelsmentioning

confidence: 99%

Research progress in the establishment of pancreatic cancer models and preclinical applications

Kong

Zhong

2022

Cancer Innovation

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Pancreatic cancer (PC) is a highly malignant tumor in the digestive system. The transformation of tissue from normal to pancreatic intraepithelial neoplasm is driven by certain oncogenes, among which the mutation rate of the KRAS gene is as high as 90%. Currently, PC has limited treatment options, low therapeutic effects, and poor prognosis. Thus, more effective methods to combat PC are urgently needed. Some models that can more accurately reflect the biological behaviors and genomic characteristics of PC, such as its morphology, pathology, proliferation, and invasion, are being continuously developed. These include genetic engineering models, orthotopic xenograft models, and heterotopic xenograft models. Using these PC models, scientists have further verified promising drugs and potential therapeutic targets for PC treatment. This is of great significance for limiting the progression of PC with clinical intervention, improving patient outcomes, and improving survival rates.

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“…Traditional Chinese medicine, which originated in China, has been practiced by Chinese people for thousands of years because of its satisfactory therapeutic effect and few side effects [8][9][10]. It has played an important role in the health care of Asians.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Mechanisms Underlying the Hepatoprotective Effects of Ecliptae herba on Hepatocellular Carcinoma

Pan

Zheng³

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. The number of hepatocellular carcinoma (HCC) cases worldwide has increased significantly. As a traditional Chinese medicine (TCM) with a long history, Ecliptae herba (EH) has been widely used in HCC patients in China, but its hepatoprotective mechanism is still unclear. Methods. In this study, we applied a network pharmacology-based strategy and experimental verification to systematically unravel the underlying mechanisms of EH against HCC. First, six active ingredients of EH were screened from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) by the ADME method. Subsequently, 52 potential targets of 6 active ingredients acting on HCC were screened from various databases, including TCMSP, DGIdb, SwissTargetPrediction, CTD, and GeneCards. Then, by constructing protein-protein interaction (PPI) network from STRING, we displayed the intricate connections among these 52 targets through Cytoscape software. We also applied enrichment analysis, including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses, to provide an outline and set of concepts for describing gene functions and the advanced functions of biological systems of these 52 targets from genomic and molecular level information. Finally, molecular docking and biological experiments were used to reconfirm these results. Results. We hypothesized that EH might exert anti-HCC activity by acting on hub genes, including RELA, MMP9, PTGS2, ESR1, EGFR, AR, AKT1, HIF1A, AHR, CYP3A4, ABCG2, and MMP2. Moreover, based on GO and KEGG analysis, we speculated that EH may exert hepatoprotective effects on HCC through the following mechanisms: regulation of the PI3K-AKT signaling pathway to promote apoptosis and inhibit the abnormal proliferation of HCC, downregulation of HIF-1A expression by activating the HIF-1 signaling pathway, prevention of HCC by regulating lipid metabolism, and inhibition of nonalcoholic fatty liver disease (NAFLD) by the cytochrome P450 subfamily. Subsequent biological experiments verified that EH inhibits the PI3K-AKT signaling pathway through its active ingredients, quercetin, and wedelolactone, thereby inhibiting the proliferation of HCC cells and promoting the apoptosis of HCC cells. Conclusions. The network pharmacological strategy provides an efficient method to systematically explore the pharmacological mechanism of EH in HCC. Our study demonstrated that the anti-HCC proliferation activity of EH is mainly exerted by two active ingredients (quercetin and wedelolactone), which inhibit the proliferation of HCC cells (HepG2 and Huh-7) by inhibiting PI3K-AKT signaling.

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Different Survival Benefits of Chinese Medicine for Pancreatic Cancer: How to Choose?

Abstract: Intervention of CM contributes to the different survival benefits for PC in different stages. Multimodality treatment might be a promising strategy for PC patients in early stage. While, in advanced stage, CM might be an alternative candidate for PC patients.

Cited by 10 publications

References 33 publications

Advances in the treatment of pancreatic cancer with traditional Chinese medicine

Advances in the treatment of pancreatic cancer with traditional Chinese medicine

Research progress in the establishment of pancreatic cancer models and preclinical applications

Pharmacological Mechanisms Underlying the Hepatoprotective Effects of Ecliptae herba on Hepatocellular Carcinoma

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