Different synaptic mechanisms of intermittent and continuous theta-burst stimulations in a severe foot-shock induced and treatment-resistant depression in a rat model

Lee, Chi‐Wei; Chu, Ming-Chia; Wu, Han-Fang; Chung, Yueh-Jung; Hsieh, Tsung‐Han; Lin, Yu‐Syuan; Lu, Ting-Yi; Chang, Ching-Hsiang; Chi, Hsiang; Chang, Hsueh‐Wei; Chen, Yih-Fung; Li, Cheng Ta; H, Lin

doi:10.1016/j.expneurol.2023.114338

Cited by 6 publications

(2 citation statements)

References 69 publications

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“…The magnetic-electric responses induced by TMS may affect BDNF levels in both serum and cerebrospinal fluid. It has been observed that iTBS treatment can reverse the decline in mature BDNF-related protein levels ( 65 ). Moreover, long-term iTBS has been found to promote neural structural and functional recovery by enhancing neurogenesis and migration through the miR-551b-5p/BDNF/TrkB pathway in cerebral ischemia–reperfusion injury models ( 66 ).…”

Section: Discussionmentioning

confidence: 99%

Prolonged intermittent theta burst stimulation for post-stroke aphasia: protocol of a randomized, double-blinded, sham-controlled trial

Liu,

Zhao,

Tang

et al. 2024

Front. Neurol.

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BackgroundPost-stroke aphasia (PSA) is one of the most devastating symptoms after stroke, yet limited treatment options are available. Prolonged intermittent theta burst stimulation (piTBS) is a promising therapy for PSA. However, its efficacy remains unclear. Therefore, we aim to investigate the efficacy of piTBS over the left supplementary motor area (SMA) in improving language function for PSA patients and further explore the mechanism of language recovery.MethodsThis is a randomized, double-blinded, sham-controlled trial. A total of 30 PSA patients will be randomly allocated to receive either piTBS stimulation or sham stimulation for 15 sessions over a period of 3 weeks. The primary outcome is the Western Aphasia Battery Revised (WAB-R) changes after treatment. The secondary outcomes include The Stroke and Aphasia Quality of Life Scale (SAQOL-39 g), resting-state electroencephalogram (resting-state EEG), Event-related potentials (ERP), brain derived neurotrophic factor (BDNF). These outcome measures are assessed before treatment, after treatment, and at 4-weeks follow up. This study was registered in Chinese Clinical Trial Registry (No. ChiCTR23000203238).DiscussionThis study protocol is promising for improving language in PSA patients. Resting-state EEG, ERP, and blood examination can be used to explore the neural mechanisms of PSA treatment with piTBS.Clinical trial registrationhttps://www.chictr.org.cn/index.html, ChiCTR2300074533.

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Section: Discussionmentioning

confidence: 99%

Prolonged intermittent theta burst stimulation for post-stroke aphasia: protocol of a randomized, double-blinded, sham-controlled trial

Liu,

Zhao,

Tang

et al. 2024

Front. Neurol.

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“…TBS, which includes Intermittent theta burst stimulation (iTBS) and continuous theta burst stimulation (cTBS), is no less effective than TMS in treating depression [28]. iTBS treatment was able to reverse the decrease in mature brain-derived neurotrophic factor-related protein levels [52]. In motor areas, iTBS increases whereas cTBS mainly decreases the excitability of targeted cortical neurons [53].…”

Section: Tbsmentioning

confidence: 99%

Current Status of Transcranial Magnetic Stimulation for Treating Depression: A Visualization and Bibliometric Analysis (Preprint)

Zhang,

xing,

wang

et al. 2024

Preprint

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BACKGROUND Background: Depression is the most disabling and prevalent psychiatric disorder; transcranial magnetic stimulation (TMS) is widely used in the treatment of depression because of its remarkable efficacy. OBJECTIVE Objective: To investigate the current status, hotspots and frontiers of this research field, and advance the research on TMS for treating depression, this paper provides a visualization and bibliometric analysis of studies related to TMS for depression. METHODS Methods: Literature related to TMS for depression was searched based on the Web of science core database from database creation to November 19, 2023. Cite Space 6.2.R4 and VOS viewer 1.6.20 were used to analyze the relevant literature in terms of annual publications, authors, institutions and international collaborations, co-cited literature, co-cited authors, co-cited journals, and keywords. RESULTS Results: A total of 4218 papers were included. The overall trend of the number of publications in this research area is increasing year by year. Research fervor is expected to continue to increase. The United States is in the top position both in terms of the number of publications and centrality. Although Canada ranks third in terms of the number of articles published, its centrality is not high. Based on the keyword co-occurrence analysis, the research hotspots in this field were clarified as efficacy, dorsolateral prefrontal cortex, prefrontal cortex, motor cortex and so on. In recent years, the keywords that have burst out and have continued until now are the treatment effectiveness, reliability, frequency, and theta burst treatment modality of TMS. These keywords may become hot spots for future research. CONCLUSIONS Conclusion: Our findings suggested that studies related to the field of TMS depression are increasingly emphasized by researchers, and the United States is an international leader in this research area. In the future, cooperation between countries should be strengthened. Meanwhile, it is important to use various imaging-assisted localization tools to carry out multi-center and large-sample clinical studies of individualized treatment parameters for TMS.

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The long-term effects of intermittent theta burst stimulation on Alzheimer's disease-type pathologies in APP/PS1 mice

Hao

Zhu

Liao

et al. 2023

Brain Research Bulletin

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Different synaptic mechanisms of intermittent and continuous theta-burst stimulations in a severe foot-shock induced and treatment-resistant depression in a rat model

Cited by 6 publications

References 69 publications

Prolonged intermittent theta burst stimulation for post-stroke aphasia: protocol of a randomized, double-blinded, sham-controlled trial

Prolonged intermittent theta burst stimulation for post-stroke aphasia: protocol of a randomized, double-blinded, sham-controlled trial

Current Status of Transcranial Magnetic Stimulation for Treating Depression: A Visualization and Bibliometric Analysis (Preprint)

The long-term effects of intermittent theta burst stimulation on Alzheimer's disease-type pathologies in APP/PS1 mice

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