Different techniques for harvesting grafts for living donor liver transplantation: A systematic review and meta-analysis

Li, Hui; Zhang, Junbin; Chen, Xiaolong; Fan, Lei; Wang, Li; Li, Shi-hui; Zheng, Qi; Wang, Xiaoming; Yang, Yang; Chen, Guihua; Wang, Genshu

doi:10.3748/wjg.v23.i20.3730

Cited by 13 publications

(19 citation statements)

References 38 publications

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“…These values were then computed from the Kaplan–Meier graph using the Engauge Digitizer software (version 4.1, M Mitchell, Engauge Digitizer, http://digitizer.sourceforge.net). 27,28 All data from the included studies were pooled using the Cochrane Collaboration’s Review Manager 5.3 (Cochrane Collaboration, Oxford, UK). A fixed effects model was used when there was no obvious heterogeneity (I 2 =0); otherwise, a random effects model was used.…”

Section: Methodsmentioning

confidence: 99%

Prognostic value of the Glasgow prognostic score in colorectal cancer: a meta-analysis of 9,839 patients

Lu¹,

Guo²,

Xu³

et al. 2018

CMAR

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PurposeThe aim of this study was to perform a systematic review and meta-analysis to evaluate the value of the Glasgow prognostic score (GPS) or modified Glasgow prognostic score (mGPS) in patients with colorectal cancer (CRC).MethodsA comprehensive medical literature search was performed using the online databases PubMed, Embase, Web of Science, and the Cochrane Library. After extracting basic characteristics and prognostic data from the included studies, overall survival (OS) and cancer-specific survival (CSS) were pooled as primary outcomes. Subgroup analyses were performed according to therapeutic strategies, models, cutoff values, regions, tumor, node, metastasis stages, sample size, and ages.ResultsForty-three independent cohorts from 41 studies with 9,839 CRC patients were included in the present study. Correlation between GPS or mGPS and OS was analyzed in 32 cohorts of 7,714 patients, and 23 independent cohorts of 5,375 patients focused on the correlation between GPS or mGPS and CSS. The overall outcomes showed that patients with elevated GPS or mGPS were associated with poor OS (HR: 2.20, 95% CI: 1.88–2.57, P<0.001). Elevated GPS or mGPS also resulted in worse CSS (HR: 1.86, 95% CI: 1.59–2.17, P<0.001). The results of the subgroup analyses confirmed the overall outcomes.ConclusionGPS or mGPS is an accurate prognostic predictor in patients with CRC. Patients with elevated pretreatment GPS or mGPS have a poor prognosis. Subgroup analyses confirmed the overall outcomes. Pretreatment GPS is a useful biomarker in the management of CRC.

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Section: Methodsmentioning

confidence: 99%

Prognostic value of the Glasgow prognostic score in colorectal cancer: a meta-analysis of 9,839 patients

Lu¹,

Guo²,

Xu³

et al. 2018

CMAR

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“…(8)(9)(10)(11) The operative duration was even shorter than that at other centers, as previously reported. (8,12) The use of a harmonic scalpel instead of a cavitron ultrasound surgical aspirator during transection of the liver parenchyma is the main reason for the shorter operative duration. The influence of the liver function of the donor was slight, and the hospital stay was only 6.0 ± 1.0 days.…”

Section: Discussionmentioning

confidence: 99%

Left Hepatic Vein Preferential Approach Based on Anatomy Is Safe and Feasible for Laparoscopic Living Donor Left Lateral Sectionectomy

Lu¹,

Wang²,

Zhu³

et al. 2020

Liver Transpl.

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We assess the safety and feasibility of the left hepatic vein preferential approach (LHVPA) based on left hepatic vein (LHV) anatomy for living donor laparoscopic left lateral sectionectomy (LLLS). Data from 50 donors who underwent LLLS in Huashan Hospital from October 2016 to November 2019 were analyzed retrospectively. On the basis of the classification of the LHV anatomy, the vein was defined as the direct import type, upper branch type, or indirect import type. A subgroup analysis was performed to compare the outcomes between the LHVPA and non-LHVPA groups. All 50 patients underwent pure LLLS. The mean operative duration was 157.5 ± 29.7 minutes. The intraoperative blood loss was 160.4 ± 97.5 mL. No complications more severe than grade 3 occurred. LHVPA was applied in 13 patients, whereas non-LHVPA was applied in 10 patients with the direct import type and upper branch type anatomy. The operative duration was shorter in the LHVPA group than the non-LHVPA group (142.7 ± 22.0 versus 173.0 ± 22.8 minutes; P = 0.01). Intraoperative blood loss was reduced in the LHVPA group compared with the non-LHVPA group (116.2 ± 45.6 versus 170.0 ± 63.3 mL; P = 0.02). The length of the LHV reserved extrahepatically in the LHVPA group was longer than in the non-LHVPA group (4.3 ± 0.2 versus 3.3 ± 0.3 mm; P = 0.01). Fewer reconstructions of the LHV in the direct import type anatomy were required for the LHVPA group than for the non-LHVPA group (0/8 versus 4/6). LHVPA based on the LHV anatomy is recommended in LLLS because it can further increase the safety and the efficiency of surgery for suitable donors.

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“…If the Kaplan-Meier survival curve was provided in the literature, the 5-year survival rate was obtained using Engauge Digtizer 1.4, and the HR was obtained using RevMan 5.3. [ 20 – 22 ] Heterogeneity analyses used the I 2 and Q tests. When I 2 <50% and the Q test P > .1, it was presumed that there was no heterogeneity, and the fixed effect model was used for analysis; otherwise, the random effect model was selected.…”

Section: Methodsmentioning

confidence: 99%

A meta-analysis on the relationship of exosomes and the prognosis of lung cancer

et al. 2021

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Background: A lot of research evidence shows that exosomes play an indelible role in the prognosis of lung cancer, but there are many disputes. Therefore, we conduct a meta-analysis to further demonstrate. Methods: A literature retrieval was performed through a search of PubMed, Embase, Web of Science, Cochrane, CKNI, Wanfang, and other databases to locate documents from the literature that satisfied the inclusion criteria. There were four outcome indicators: overall survival (OS), disease-free survival (DFS), disease-specific survival (DSS), and progression-free survival (PFS). Subgroup analysis was conducted according to sample size, country, detection method, analysis method, and pathological type. Stata 14.0 software was used to evaluate the prognostic value of exosomes in lung cancer. Results: A total of 2456 patients with lung cancer from 29 studies in 16 articles were included. The expression level of exosomes was closely associated with the OS and DFS of patients, although no statistical difference was observed between exosomes and DSS or PFS. Eighteen studies with 2,110 patients were evaluated to examine the prognostic value of exosomes in lung cancer by exploring the association between exosomes and OS. The results showed that exosomes were strongly associated with worse OS, and the combined hazard ratio (HR) was 2.01 (95% confidence interval [CI]: 1.70–2.39, P = .000). Six studies investigated the association between exosomes and DFS, and showed a pooled HR of 2.48 (95% CI: 1.75–3.53, P = .000). Conclusion: Our analysis indicated that the expression level of exosomes was closely associated with the OS and DFS of patients with lung cancer, suggesting that exosomes are associated with poor prognosis of lung cancer. Exosomes may be a new biomarker for the prognosis of lung cancer, although a large number of prospective studies are still needed to support this.

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Different techniques for harvesting grafts for living donor liver transplantation: A systematic review and meta-analysis

Cited by 13 publications

References 38 publications

Prognostic value of the Glasgow prognostic score in colorectal cancer: a meta-analysis of 9,839 patients

Prognostic value of the Glasgow prognostic score in colorectal cancer: a meta-analysis of 9,839 patients

Left Hepatic Vein Preferential Approach Based on Anatomy Is Safe and Feasible for Laparoscopic Living Donor Left Lateral Sectionectomy

A meta-analysis on the relationship of exosomes and the prognosis of lung cancer

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