Different techniques for overlapped UV spectra resolution of some co-administered drugs with paracetamol in their combined pharmaceutical dosage forms

Sebaiy, Mahmoud M.; El-Adl, Sobhy M.; Mattar, Amr A.

doi:10.1016/j.saa.2019.117429

Cited by 23 publications

(15 citation statements)

References 26 publications

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“…This was carried out by adding a fixed amount of standard CAF to each experiment when combined with APAP, then subtraction of its concentration before the calculation of the required CAF concentration. Sample enrichment technique has been used also for solving the same problem in the analysis of other drug mixtures of different drug ratios [30][31][32].…”

Section: Methods Optimizationmentioning

confidence: 99%

Spectrum subtraction method for simultaneous determination of acetaminophen and caffeine in panadol extra dosage forms

Sebaiy

Mattar

2020

Eur J Chem

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A simple, specific, accurate and precise spectrophotometric method was established for simultaneous determination of acetaminophen and caffeine in pure form and in their pharmaceutical formulation commercially known as Panadol Extra®. Spectrum subtraction has been used in simultaneous determination of both drugs without prior separation. Spectrum subtraction method parameters were validated according to ICH guidelines in which accuracy, precision, repeatability and robustness were found in accepted limits (98-102%). The linearity range was 7.5-45 µg/mL for caffeine and 4-22 µg/mL for acetaminophen with correlation coefficients ≥0.9990 for both drugs. Advantages and disadvantages of spectrum subtraction were discussed and statistical comparison between the proposed method and the reference one was performed.

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Section: Methods Optimizationmentioning

confidence: 99%

Spectrum subtraction method for simultaneous determination of acetaminophen and caffeine in panadol extra dosage forms

Sebaiy

Mattar

2020

Eur J Chem

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“…Aceclofenac three of its tablet dosage forms, that is, Alkeris®, Airtal® and Acenac® (100 mg tablets in Pakistan) were analysed using UV Spectrophotometer. Validation studies were conducted for determination of linearity, specificity, precision (repeatability and intermediate precision), and limit of detection (Sebaiy et al, 2020).…”

Section: Uv-visible Spectrophotometric Methodsmentioning

confidence: 99%

Development and validation of UV- Spectrophotometric and RP-HPLC method for the analysis of raw material and formulations of Aceclofenac

Jamshaid¹,

Hassan²,

Ahmed³

et al. 2020

Afr. J. Pharm. Pharmacol.

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The purpose of the study is to develop and validate method for assay of Aceclofenac in tablet dosage forms using ultra violet spectrophotometry (UV) and high performance liquid chromatography (HPLC) techniques. A method was developed and validated for analysis of Aceclofenac using UV technique with methanol and phosphate buffer 7.4 as solvent. The HPLC analysis was conducted using two mobile phases, that is, "A" as Acetonitrile: Methanol (80:20 v/v) and "B" as Acetonitrile: methanol: NH 3 solution (225:50:1 v/v/v). The method was used for assay determination for tablets dosage forms and results were found to be in compliance with official standards. Validation studies were also carried out for both methods. Linearity, LOD, single point calibration, precision and accuracy and % RSD were calculated. Aceclofenac standard was analysed with UV Spectrophotometer in the concentration ranges of 0.5-50 and 0.4-50 mg/L for each solvent and results showed good linearity with R 2 = 0.9998 and 0.9999. The method was also specific that verifies the absence of interference at the  max of Aceclofenac. UV analysis was precise with % RSD falling within 2% and LOD as 0.5 and 0.4 mg/L for methanol and PBS 7.4, respectively. The tablets of three brands showed assay percentages within specified limits in methanol (109.33, 103.90 and 105.61%) and PBS 7.4 (108.70, 100.69 and 106.60%). In HPLC analysis, mobile phase "B" showed more sharp peaks with lesser HETP and T f compared to mobile phase "A". The method was checked for reliability and efficiency for assay and some of the parameters like height efficiency to theoretical plates (HETP), tailing factor, peak heights, peak widths along with validation studies (Linearity range 0.1-50 mg/L, specificity, precision, and limit of detection and single point calibration). The more basic mobile phase B using NH 3 solution produced more sharp peaks as compared to less basic mobile phase A.

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“…1) is a psycho stimulant purine alkaloid that can increase alertness. CAF can increase the effect of analgesic and antipyretic drugs so it is combined with them in many pharmaceutical preparations [2].…”

Section: Introductionmentioning

confidence: 99%

UV-Chemometric Method Development for Resolving The Overlapped Spectra of Aspirin, Caffeine and Orphenadrine Citrate in Their Ternary Pharmaceutical Dosage Form

Sebaiy

Mattar

El-Adl

2022

Preprint

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A simple, specific, accurate and precise UV-chemometric methods have been developed for the analysis of aspirin, caffeine and orphenadrine citrate in their ternary mixture form without prior separation. CLS, PLS and PCR were developed for simultaneous determination of the three drugs together by using different sets of data in which better results were produced. Unfortunately, PLS method was the only method which was able to determine them accurately. The validity of these chemometric methods has been carried out by 8 synthetic mixtures for determination of the power of prediction for each method. Latent variable number is different from one model to another with changing the set of data. Predicted residual error sum of squares (PRESS) and root mean square error of prediction (RMSEP) were used for comparison between different methods and for determination the predictive power of each set of data. In addition, statistical comparison between the proposed chemometric methods was performed.

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Different techniques for overlapped UV spectra resolution of some co-administered drugs with paracetamol in their combined pharmaceutical dosage forms

Cited by 23 publications

References 26 publications

Spectrum subtraction method for simultaneous determination of acetaminophen and caffeine in panadol extra dosage forms

Spectrum subtraction method for simultaneous determination of acetaminophen and caffeine in panadol extra dosage forms

Development and validation of UV- Spectrophotometric and RP-HPLC method for the analysis of raw material and formulations of Aceclofenac

UV-Chemometric Method Development for Resolving The Overlapped Spectra of Aspirin, Caffeine and Orphenadrine Citrate in Their Ternary Pharmaceutical Dosage Form

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