Different Types of Honey and Their Properties

Farooq, Rabia; Majid, Sabhiya; Hanif, Aamir; Ashraf, Ahila; Khan, Andleeb

doi:10.1007/978-981-15-6799-5_13

Cited by 9 publications

(6 citation statements)

References 89 publications

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“…Natural products, such as honey, could be a valuable source of interesting bioactive compounds with prominent anticancer potential [ 31 , 33 , 35 , 36 ]. This activity may vary according to floral origin, geographic region, season, or altitudes [ 4 , 5 ]. More than 200 honey constituents have been identified, including sugars, amino acids, polypeptides, minerals, and vitamins.…”

Section: Discussionmentioning

confidence: 99%

“…Several results showed prominent anticancer activity displayed by various honey types [ 4 ]. Honey content may vary according to floral origin, the geographical area considering the same floral origin, season, altitude, and species of honeybees [ 4 , 5 , 6 ]. Monofloral honey derived from the nectar of one plant species has a high virtue compared with polyfloral honey [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical Composition, Antioxidant, and Anticancer Activities of Sidr Honey: In Vitro and In Silico Computational Investigation

Bouali

Hamadou

Badraoui

et al. 2022

Life

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Cancer is one of the major causes of death worldwide. The repercussions of conventional therapeutic approaches present a challenge in the delivery of new effective treatments. Thus, more attention is being awarded to natural products, mainly honey. Honey could be the basis for the development of new therapies for cancer patients. The aim of this study is to assess the phytochemical profiling, antioxidant, drug-likeness properties, and anticancer activity of Ziziphus honey (ZH) derived from the Hail region of Saudi Arabia. The phytochemical profiling using high resolution-liquid chromatography mass spectrometry (HR-LCMS) revealed 10 compounds belonging to several familial classes and one tripeptide. Potential antioxidant activity was noted as assessed by DPPH (IC50 0.670 mg/mL), ABTS (IC50 3.554 mg/mL), and β-carotene (IC50 > 5 mg/mL). The ZH exerted a notable cytotoxic effect in a dose-dependent manner against three cancer cell lines: lung (A549), breast (MCF-7), and colon (HCT-116), with respective IC50 values of 5.203%, 6.02%, and 7.257%. The drug-likeness investigation unveiled that most of the identified compounds meet Lipinski’s rule. The molecular docking analysis revealed interesting antioxidant and anticancer activities for most targeted proteins and supported the in vitro findings. The Miraxanthin-III compound exhibited the most stabilized interaction. This study provides deeper insights on ZH as prominent source of bioactive compounds with potent antioxidant and anticancer effects.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phytochemical Composition, Antioxidant, and Anticancer Activities of Sidr Honey: In Vitro and In Silico Computational Investigation

Bouali

Hamadou

Badraoui

et al. 2022

Life

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“…Earlier studies have reported that the anticancer potential of honey may vary with the subtype of honey, even when the same honey from different geographical regions is used. This variation is attributed to the variations in the constituents of the honey samples [ 64 ]. The anticancer properties of honey have been attributed mainly to the phytochemicals present in the honey, particularly the flavonoids and phenolic acids.…”

Section: Discussionmentioning

confidence: 99%

Chemical Composition and the Anticancer, Antimicrobial, and Antioxidant Properties of Acacia Honey from the Hail Region: The in vitro and in silico Investigation

Hamadou

Bouali

Badraoui

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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In consideration of the emergence of novel drug-resistant microbial strains and the increase in the incidences of various cancers throughout the world, honey could be utilized as a great alternative source of potent bioactive compounds. In this context, this study pioneers in reporting the phytochemical profiling and the antimicrobial, antioxidant, and anticancer properties of Acacia honey (AH) from the Hail region of Saudi Arabia, assessed using in vitro and molecular docking approaches. The phytochemical profiling based on high-resolution liquid chromatography-mass spectrometry (HR-LCMS) revealed eight compounds and three small peptide-like proteins as the constituents. The honey samples exhibited promising antioxidant activities (DPPH-IC50 = 0.670 mg/mL; ABTS-IC50 = 1.056 mg/mL; β-carotene-IC50 > 5 mg/mL). In the well-diffusion assay, a high mean growth inhibition zone (mGIZ) was observed against Staphylococcus aureus (48.33 ± 1.53 mm), Escherichia coli ATCC 10536 (38.33 ± 1.53 mm), and Staphylococcus epidermidis ATCC 12228 (39.33 ± 1.15 mm). The microdilution assay revealed that low concentrations of AH could inhibit the growth of almost all the evaluated bacterial and fungal strains, with the minimal bactericidal concentration values (MBCs) ranging from 75 mg/mL to 300 mg/mL. On the contrary, high AH concentrations were required to kill the tested microorganisms, with the minimal bactericidal concentration values (MBCs) ranging from approximately 300 mg/mL to over 600 mg/mL and the minimal fungicidal concentration values (MFCs) of approximately 600 mg/mL. The AH exhibited effective anticancer activity in a dose-dependent manner against breast (MCF-7), colon (HCT-116), and lung (A549) cancer cell lines, with the corresponding IC50 values of 5.053 μg/mL, 5.382 μg/mL, and 6.728 μg/mL, respectively. The in silico investigation revealed that the observed antimicrobial, antioxidant, and anticancer activities of the constituent compounds of AH are thermodynamically feasible, particularly those of the tripeptides (Asp-Trp-His and Trp-Arg-Ala) and aminocyclitol glycoside. The overall results highlighted the potential of AH as a source of bioactive compounds with significant antimicrobial, antioxidant, and anticancer activities, which could imply further pharmacological applications of AH.

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“…It is used in the treatment of heart diseases, it helps to lower blood cholesterol and high blood pressure, and helps in the treatment of the digestive system, including gastric and duodenal ulcers (Hołderna‐Kędzia et al, 2012). Due to its high iron content, it is used in the treatment of anemia (Farooq et al, 2020). In addition, it includes macronutrients such as phosphorus and magnesium as well as vitamins.…”

Section: Characteristics Of Selected Bee Productsmentioning

confidence: 99%

Recent advances and opportunities related to the use of bee products in food processing

Kieliszek

Piwowarek

Kot

et al. 2023

Food Science & Nutrition

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One of the oldest examples of the existence of beekeeping is the murals from the Araña Cave in Spain, which show people collecting honey from the nest of untamed bees. In ancient times, honey was used as a medicine and also to embalm corpses. During Greek feasts, it was an indispensable part of the menu. However, the greatest boom in beekeeping took place in ancient Rome, where hives made of straw and clay were found, dating back to 900 B.C. (Kritsky, 2017). The Egyptians placed a vessel filled with a "golden drink" in the tombs of the pharaohs, which showed that it was indeed considered something special. In the beginning, people discovered that honey collected by bees can be found in the hollows of trees. They climbed these trees, taking the honey from the bees-the result of their hard work. Then, they started to breed bees, building their nests in the hollows of old trees, the so-called beehives. Shortly thereafter, they noticed that you can only relocate the part of the tree to the field where the hollow is located, and then you will not have to climb to ensure you have constant access to this valuable product. Over time, people, thinking

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Different Types of Honey and Their Properties

Cited by 9 publications

References 89 publications

Phytochemical Composition, Antioxidant, and Anticancer Activities of Sidr Honey: In Vitro and In Silico Computational Investigation

Phytochemical Composition, Antioxidant, and Anticancer Activities of Sidr Honey: In Vitro and In Silico Computational Investigation

Chemical Composition and the Anticancer, Antimicrobial, and Antioxidant Properties of Acacia Honey from the Hail Region: The in vitro and in silico Investigation

Recent advances and opportunities related to the use of bee products in food processing

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