Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease

Zhang, Nan; Zele, Thibaut Van; Pérez-Novo, Claudina; Bruaene, Nicholas Van; Holtappels, Gabriële; Deruyck, Natalie; Cauwenberge, Paul Van; Bachert, Claus

doi:10.1016/j.jaci.2008.07.008

Cited by 562 publications

(547 citation statements)

References 34 publications

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“…These findings were later confirmed in Chinese CRS subjects 29 , although these are characterized by different T effector cell profiles than their Caucasian counterparts 9 . In our study, CRSsNP subjects were confirmed to have increased TGF-β1 concentrations compared to CRSwNP subjects and controls (p<0.001, data not shown 31 .…”

Section: Discussionmentioning

confidence: 73%

“…Furthermore, there are additional subtypes such as allergic fungal rhinosinusitis, CRS associated with aspirinexacerbated respiratory disease, and with cystic fibrosis which may present as CRSwNP or CRSwNP in Caucasians 7,8 . However, subsequent studies reported a wider spectrum of immunologic profiles, especially in non-Caucasian phenotypes 9 , expressing a neutrophilic type of inflammation with involvement of other T-cell subsets such as Th1 and Th17 cells.…”

Section: Introductionmentioning

confidence: 99%

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Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers

Tomassen

Vandeplas

Zele

et al. 2016

Journal of Allergy and Clinical Immunology

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932

934

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Section: Discussionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers

Tomassen

Vandeplas

Zele

et al. 2016

Journal of Allergy and Clinical Immunology

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932

934

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“…48 Bacterial-derived superantigen expression can be identified in up to 90% of patients with CS. 8 Because the T cells infiltrating the sinuses of CHES generally display a Th2 cytokine signature, 51 this superantigen-mediated surge in cytokines will include IL-4 and IL-13, production of which will drive any B cells present to synthesize IgE antibodies to any humoral antigen to which that B cell is responding at that moment. As a specific example of this mechanism, this interaction leads to the formation of IgE in the sinus tissue to the Staphylococcus enterotoxin itself, and these IgE antibodies can be identified in 27.8% of CS with NPs and 53.8% of CS with both NPs and asthma.…”

Section: Sensitization To Colonizing Pathogens Bacteriamentioning

confidence: 99%

Chronic sinusitis pathophysiology: The role of allergy

Kennedy

Borish

2013

Am J Rhinol�Allergy

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“…All of the CRSwNP patients and controls underwent the supernatant tests. As described previously, eosinophilic CRSwNP is characterized by a supernatant ECP/MPO ratio >2 (14). According to this criterion, 18 patients were assigned to an eosinophilic CRSwNP group, and the others were assigned to the non-eosinophilic CRSwNP group.…”

Section: Resultsmentioning

confidence: 99%

Different roles of Staphylococcus aureus enterotoxin in different subtypes of nasal polyps

Cheng

Wang

2016

Experimental and Therapeutic Medicine

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Abstract. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disease. The pathogenesis of CRSwNP remains unclear. This study was designed to investigate the role of inflammation and Staphylococcus aureus enterotoxin (SE) in this disease. The study included a total of 74 patients with CRSwNP and 6 controls. A serum Phadiatop assay was conducted to detect atopy status, and serum eosinophil cationic protein (ECP) and total immunoglobulin (Ig)E levels were determined using ELISA. SEA, SEB, total IgE, ECP and myeloperoxidase (MPO) levels in nasal tissue supernatant were measured using ELISA. The results indicated that 15 (22.1%) patients had systemic allergies. On the basis of the ECP/MPO ratio, the patients were divided into an eosinophilic CRSwNP group (n=18) and a non-eosinophilic CRSwNP group (n=56). The total ECP/MPO ratio was 0.572, with a notable bias toward neutrophilic inflammation. The supernatant ECP and MPO levels were elevated in the CRSwNP group compared with the control group, but no significant difference in the serum total IgE and ECP levels were observed between the CRSwNP and control groups. In addition, the non-eosinophilic and eosinophilic CRSwNP groups showed significant elevations in supernatant total IgE, SEA and SEB levels compared with the control group. Thus, it may be concluded that allergy is a common pathogenesis of CRSwNP, and neutrophilic inflammation is present in most Chinese CRSwNP patients. Additionally, local indicators reflect the inflammatory status more accurately than do serum indicators. SEs may act as an infection factor rather than as a superantigen in Chinese non-eosinophilic CRSwNP patients. Thus, long-term antibiotic therapy may be an option for Chinese non-eosinophilic CRSwNP patients.

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Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease

Cited by 562 publications

References 34 publications

Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers

Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers

Chronic sinusitis pathophysiology: The role of allergy

Different roles of Staphylococcus aureus enterotoxin in different subtypes of nasal polyps

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