Different types of working memory binding in epilepsy patients with unilateral anterior temporal lobectomy

Binding deficits in visual short‐term memory in patients with temporal lobe lobectomy

“…The results point to a specific involvement of MTL in object-location binding, but, crucially, not retention of either object identity or location. These findings are consistent with results from investigations that have identified a role for the MTL in relational binding for LTM, supporting the proposal that MTL regions perform such a function for both STM and LTM (Esfahani-Bayerl et al, 2016;Olson, Moore, Stark, & Chatterjee, 2006;van Geldorp, Bouman, Hendriks, & Kessels, 2014;Yonelinas, 2013).…”

“…The distinction between short-and long-term memories has been established over many years by studying patients with MTL damage (Baddeley, Allen, & Vargha-Khadem, 2010;Jeneson, Mauldin, & Squire, 2010;Jeneson & Squire, 2012;Shrager, Levy, Hopkins, & Squire, 2008;Squire, 2017). Contrary to these findings, some neuroimaging and patient studies have presented evidence in favor of a possible role of the MTL in STM (Esfahani-Bayerl et al, 2016;Olson, Page, Moore, Chatterjee, & Verfaellie, 2006;van Geldorp et al, 2014;Watson, Voss, Warren, Tranel, & Cohen, 2013). In an attempt to reconcile these findings, it has been argued that MTL structures do not play a role in all aspects of STM but perform a specific computation: relational binding of information bringing together disparate elements of an episodic (Davachi, 2006;Eichenbaum, Yonelinas, & Ranganath, 2007) or short-term memories (Koen, Borders, Petzold, & Yonelinas, 2016;Pertzov et al, 2013).…”

Differential age-related effects on conjunctive and relational visual short-term memory binding

“…Neuroimaging studies have also demonstrated that the hippocampus is activated during relational binding in short-term memory tasks Piekema, Kessels, Rijpkema, & Fernandez, 2009;Piekema, Kessels, Mars, Petersson, & Fernández, 2006;Piekema, Rijpkema, Fernandez, & Kessels, 2010). Neuropsychological evidence additionally pointed to a crucial role of the hippocampus for relational short-term binding (Hannula et al, 2015;Olson, Page, Moore, Chatterjee, & Verfaellie, 2006;Parra et al, 2015;van Geldorp, Bouman, Hendriks, & Kessels, 2014). So, it is likely that age-related changes to the hippocampus explain at least partly the decrease in relational short-term binding.…”

“…An fMRI study indicated that a conjunctive visual short-term binding task activated temporoparietal and occipital regions, but not the hippocampus (Parra, Della Sala, Logie, & Morcom, 2014). Also patients with hippocampal lesions remain able to retain conjunctive associations in short-term memory (Baddeley, Allen, & Vargha-Khadem, 2010;Parra et al, 2015;van Geldorp et al, 2014). Consequently, conjunctive short-term binding should be relatively immune to age effects if it depends on brain regions that are unaffected by aging.…”

Working memory binding and episodic memory formation in aging, mild cognitive impairment, and Alzheimer’s dementia

“…Standard neuropsychological tests often reveal no deficits (Guarch, Marcos, Salamero, Gasto, & Blesa, 2008;Kramer et al, 2006), but recent studies have shown that the MTL may be involved in working memory, especially when multiple items or features have to be associated (i.e., binding). For example, lesion studies show that patients with damage to MTL structures have deficits in maintaining bound information over short periods of time (Braun et al, 2011;Della Sala, Parra, Fabi, Luzzi, & Abrahams, 2012;Hannula & Ranganath, 2008;Jeneson, Mauldin, & Squire, 2010;Olson, Page, Moore, Chatterjee, & Verfaellie, 2006;Van Geldorp, Bouman, Hendriks, & Kessels, 2014). These deficits may be related to damage to extrahippocampal MTL structures, since patients with lesions limited to the hippocampus proper do not show deficits on working memory binding tasks (see, e.g., Allen, Vargha-Khadem, & Baddeley, 2014).…”