Different unfractionated heparin doses for preventing arterial thrombosis in children undergoing cardiac catheterization

Avila, Laura; Shah, Prakeshkumar S; Brandão, Leonardo R.

doi:10.1002/14651858.cd010196.pub3

Cited by 6 publications

(5 citation statements)

References 61 publications

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“…The secondary mortality and major complications such as excessive bleeding requiring blood transfusion and vascular rupture were not observed due to cardiac catheterization. The fluoroscopy time was median 10,5 (8)(9)(10)(11)(12)(13)(14)(15) min in diagnostic catheterization and median 15,5 (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26) min in interventional catheterization (p=0,001). Eight of the cases (40%) were female, and 12 of them (60%) were male.…”

Section: Resultsmentioning

confidence: 99%

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Arterial Thrombosis Secondary to Cardiac Catheterization in Neonates

Erol¹,

Aydın²,

Çınar³

et al. 2019

Dicle Tıp Dergisi

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Methods: Twenty newborns that received femoral artery catheterization within 6-month period were enrolled in this study. Blood samples were taken for complete blood count, prothrombin, activated partial thromboplastin time, INR ratio and mutations of factorV Leiden, prothrombin 20210A, methylenetetrahydrofolate reductase C667T and A1298 before the procedure. 100 U/kg bolus of heparin was infused during catheterization. 28 U/kg/hour infusion of heparin was given to the patients with clinically suspected thrombosis during first few hours after catheterization. Doppler ultrasonography was performed in all patients within 6 hours after catheterization. Results: The gestational age of patients ranged from 31 to 40 weeks (median 39). Mean birth weight was 2996 ± 589 (1880-4000 gr). Arterial thrombosis was detected in 10 patients by Doppler USG. On development of arterial thrombosis, patient age, gender, diagnosis, treatments, platelet count, hemoglobin, prothrombin and activated partial thromboplastin time values, FactorV Leiden, prothrombin 20210A, methylenetetrahydrofolate reductase C667T and A1298 mutations were found as not impacting (p>0.05). Those who were found to have thrombosis in Doppler ultrasonography had lower INR levels compared to others (p= 0.023).

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Section: Resultsmentioning

confidence: 99%

“…During cardiac catheterization, some centers routinely apply heparin infusion into the artery or the vein that received catheter with pediatric patients 7 . There is little research in literature studying the effects of giving prophylactic systemic heparin during cardiac catheterization on the frequency of thrombosis in newborns 8 .…”

Section: Introductionmentioning

confidence: 99%

Arterial Thrombosis Secondary to Cardiac Catheterization in Neonates

Erol¹,

Aydın²,

Çınar³

et al. 2019

Dicle Tıp Dergisi

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“…Fewer attempts at arterial puncture, use of a smaller sheath, maintaining a minimum procedure time, and ensuring that back bleed is present can prevent future occurrences of postcatheterization thrombosis (24). A review article published in 2014 still demonstrated uncertainty on the suitable dosage of heparin to prevent this major complication (25). Similarly, although patient case #2 underwent both TAE and PS, intraoperative blood transfusion was ultimately necessary.…”

Section: Discussionmentioning

confidence: 99%

A multi-step approach to the treatment of giant scalp congenital hemangiomas: a report of two cases

Nonnenmacher

Henkes

et al. 2023

Front. Surg.

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“…Высокомолекулярный гепарин используется для лечения венозного тромбоза, тромбоэмболии легочной артерии и других заболеваний из-за его быстрого начала действия, тогда как пероральные антикоагулянты (такие как варфарин) обладают медленным началом действия. До настоящего времени высокомолекулярный гепарин является наиболее часто употребляемым антикоагулянтом при терапии острых тромбозов для лечения пациентов от момента рождения до преклонного возраста [7,11,12]. Чаще всего высокомолекулярный гепарин применяют в очень высоких дозах, длительное время (от 4 до 20 дней и более).…”

Section: Introductionunclassified

“…Чаще всего высокомолекулярный гепарин применяют в очень высоких дозах, длительное время (от 4 до 20 дней и более). Например, для лечения тромботических осложнений у детей малой дозой считается доза менее 100 ЕД/кг, а высокойболее 100 ЕД/кг [12]. У некоторых пациентов (5-15%) высокомолекулярный гепарин может индуцировать образование антител, которые способны вызвать жизнеугрожающий синдром, известный как гепарин-индуцированная тромбоцитопения.…”

Section: Introductionunclassified

Mast Cells Heparin — New Information on the Old Component (Review)

Kondashevskaya

Владиславовна²

2021

Annals RAMS

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Mast cells (MC) are widely distributed throughout the body of animals and humans, mainly in barrier tissues. This review provides new information on the hematopoietic origin of MCs from early erythromyeloid progenitors (EMPs), late EMPs, and definitive hematopoietic stem cells. As well as information on the maturation of MSs and heparin synthesis already in the embryonic period. Many physiological functions of MCs are determined by the properties of heparin, which forms the basis of the matrix of granules, since the heparin molecule is a strong polyanion, capable to forming complexes with many biologically active substances and regulating their properties. In a new hypothesis about the participation of MCs in pathological processes, it is assumed that this is due to the depletion of the heparin pool. In such cases, injections of exogenous heparin can help replenish MCs heparin stores. As a result of the restoration of the physiological functions of MCs and the action of exogenous heparin, the pathological process will be converted into an adaptive one. In clinical practice, unfractionated heparin (UFH) obtained from natural sources and low molecular weight heparin (LMWH) obtained by the biochemical route are used. Most often, UFH and LMWH are used in the clinic only as anticoagulants. The worldwide spread of a disease named COVID-19 in 2020 showed that UFH and LMWH are multifunctional drugs that have saved many people. The pandemic caused by COVID-19 has been an unprecedented social and health emergency worldwide. Depression, anxiety and post-traumatic stress disorder (PTSD) have been reported in populations of many countries. This review provides new information on experimental studies on the successful treatment of pathology with low doses of UFH in modeling PTSD in animals. Consequently, heparin can be considered as a promising multifunctional drug for effective pharmacological correction of comorbid diseases under the influence of extreme factors.

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Different unfractionated heparin doses for preventing arterial thrombosis in children undergoing cardiac catheterization

Cited by 6 publications

References 61 publications

Arterial Thrombosis Secondary to Cardiac Catheterization in Neonates

Arterial Thrombosis Secondary to Cardiac Catheterization in Neonates

A multi-step approach to the treatment of giant scalp congenital hemangiomas: a report of two cases

Mast Cells Heparin — New Information on the Old Component (Review)

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