2013
DOI: 10.5702/massspectrometry.a0024
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Differential 14N/15N-Labeling of Peptides Using N-Terminal Charge Derivatization with a High-Proton Affinity for Straightforward de novo Peptide Sequencing

Abstract: While de novo peptide sequencing is essential in many situations, it remains a difficult task. This is because peptide fragmentation results in complicated and often incomplete product ion spectra. In a previous study, we demonstrated that N-terminal charge derivatization with 4-amidinobenzoic acid (Aba) resulted in improved peptide fragmentation under lowenergy CID conditions. However, even with this derivatization, some ambiguity exists, due to difficulties in discriminating between N-and C-terminal fragment… Show more

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