2020
DOI: 10.3390/ijms21051871
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Differential Abilities of Mammalian Cathelicidins to Inhibit Bacterial Biofilm Formation and Promote Multifaceted Immune Functions of Neutrophils

Abstract: Mammalian cathelicidins act as the potent microbicidal molecules for controlling bacterial infection, and are considered promising alternatives to traditional antibiotics. Their ability to modulate host immune responses, as well as their bactericidal activities, is essential for therapeutic interventions. In this study, we compared the bactericidal activities, antibiofilm activities and immune-modulatory properties of cathelicidins BMAP-27, BMAP-34, mCRAMP, and LL-37, and evaluated the therapeutic efficacy of … Show more

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Cited by 17 publications
(14 citation statements)
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“…Nevertheless, high similarities were observed between canine, murine, human, and feline sequences [147]. Furthermore, the effects achieved by different types of cathelicidins varies [151], as well as their relative amount in the neutrophils [148].…”
Section: Cytoplasm and Granulesmentioning
confidence: 99%
“…Nevertheless, high similarities were observed between canine, murine, human, and feline sequences [147]. Furthermore, the effects achieved by different types of cathelicidins varies [151], as well as their relative amount in the neutrophils [148].…”
Section: Cytoplasm and Granulesmentioning
confidence: 99%
“…Notably, the vulnerability of planktonic cells to a particular antimicrobial agent is not indicative of the vulnerability of the biofilm cells [118][119][120]. For instance, LL-37 has shown to display strong biofilm prevention against strains of S. aureus that are resistant to LL-37 [118].…”
Section: Biofilmsmentioning
confidence: 99%
“…The hydrophobicity of LL-37 plays a role in membrane disruptions and bactericidal activities. Following the adsorption of LL-37 onto the bacterial cell membrane, the hydrophobic residues are able to facilitate further penetration into the membrane, and to disorganize the lipid tail region of the membrane [120]. In addition, amphiphilicity-the separation of charged groups from hydrophobic residues-promotes interactions with the membrane and penetration into the lipid bilayer [153].…”
Section: Hydrophobicitymentioning
confidence: 99%
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