Differential ability of periodontopathic bacteria to modulate invasion of human gingival epithelial cells by Porphyromonas gingivalis

Saitô, Atsushi; Inagaki, Shigenori; Ishihara, Kazuyuki

doi:10.1016/j.micpath.2009.09.012

Cited by 42 publications

(54 citation statements)

References 29 publications

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“…A study by Saito et al showed that F. nucleatum, a resident of the oral cavity, enhances the transportation of P. gingivalis inside epithelial cell monolayers in vitro. However, coincubation with another species, A. actinomycetemcomitans or T. forsythia, resulted in the abrogation of P. gingivalis invasion (184). The enhanced invasion of the epithelium may promote the further degradation of gum tissue and increase host inflammation.…”

Section: Considerations For Design and Use Of Polymicrobial Vaccinesmentioning

confidence: 99%

Polymicrobial Interactions: Impact on Pathogenesis and Human Disease

et al. 2012

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SUMMARY Microorganisms coexist in a complex milieu of bacteria, fungi, archaea, and viruses on or within the human body, often as multifaceted polymicrobial biofilm communities at mucosal sites and on abiotic surfaces. Only recently have we begun to appreciate the complicated biofilm phenotype during infection; moreover, even less is known about the interactions that occur between microorganisms during polymicrobial growth and their implications in human disease. Therefore, this review focuses on polymicrobial biofilm-mediated infections and examines the contribution of bacterial-bacterial, bacterial-fungal, and bacterial-viral interactions during human infection and potential strategies for protection against such diseases.

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Section: Considerations For Design and Use Of Polymicrobial Vaccinesmentioning

confidence: 99%

Polymicrobial Interactions: Impact on Pathogenesis and Human Disease

et al. 2012

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“…The previously accepted "red complex"-along with other cultivable bacteria species, such as Prevotella intermedia, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Selenomonas noxia, and Eubacterium nodatum-is associated with periodontitis (Kolenbrander et al, 2002(Kolenbrander et al, , 2006Saito et al, 2009). In addition, organisms such as Selenomonas, Synergistes, Desulfobulbus, TM7 (new candidate bacterial division), and Filifactor alocis have been identified as potential pathogens in a number of independent studies (Dewhirst et al, 2010;Griffen et al, 2012).…”

Section: Yet-to-be-cultured Bacterial Communitiesmentioning

confidence: 99%

Filifactor alocis: The Newly Discovered Kid on the Block with Special Talents

2014

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Infection-induced periodontal disease has been primarily focused on a small group of periodontal pathogens. A paradigm shift, based on data emerging from the oral microbiome project, now suggests the involvement of as-yet-unculturable and fastidious organisms. Collectively, these studies have demonstrated that there are changes in the periodontal status associated with shifts in the composition of the bacterial community in the periodontal pocket. In addition, it is likely that the emerging new pathogens may play a more significant role in the disease. One of the organisms previously unrecognized is Filifactor alocis. While this Gram-positive anaerobic rod has been identified in peri-implantitis, in endodontic infections, and in patients with localized aggressive periodontitis, its presence is now observed at significantly higher levels in patients with adult periodontitis or refractory periodontitis. Its colonization properties and its potential virulence attributes support the proposal that F. alocis should be included as a diagnostic indicator of periodontal disease. Moreover, these emerging characteristics would be consistent with the polymicrobial synergy and dysbiosis (PSD) periodontal pathogenesis model. Here, unique characteristics of F. alocis are discussed. F. alocis has specific factors that can modulate multiple changes in the microbial community and host cell proteome. It is likely that such variations at the molecular level are responsible for the functional changes required to mediate the pathogenic process.

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“…Historically, periodontal disease is associated with several pathogens contributing to a complex microbial milieu which can initiate or directly contribute to host tissue destruction (5). Bacteria such as Porphyromonas gingivalis, Prevotella intermedia, Aggregatibacter (Actinobacillus) actinomycetemcomitans, Tannerella forsythia, and Treponema denticola have previously been demonstrated to be major pathogens associated with periodontal diseases (6)(7)(8). A comparative oral microbiome analysis of the healthy and diseased states has indicated diversity in the microbial communities (9,10).…”

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confidence: 99%