Differential activation of cerebral blood flow by stimulating amblyopic and fellow eye

Mizoguchi, Shoichi; Suzuki, Yukihisa; Kiyosawa, Motohiro; Mochizuki, Manabu; Ishii, Kenji

doi:10.1007/s00417-004-1009-5

Cited by 25 publications

(14 citation statements)

References 25 publications

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“…Furthermore, the results of the AMB group differ from those of the normal group most clearly in the lower temporal frequencies (pattern reversal rates 5 and 10 Hz), and in the first harmonic component. Recent functional MRI scanning and PET studies support those results [13,14].…”

Section: Discussionsupporting

confidence: 59%

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Fourier-analysed Steady-state VEPs in Pre-school Children with and without Normal Binocularity

Johansson

Jakobsson

2006

Doc Ophthalmol

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Pre-school children aged 4-5 were examined with steady-state VEP in response to a sinusoidal grating pattern with a spatial frequency of 4 c/deg, reversing at rates 5, 10, and 15 Hz. Normal children (n = 10) were compared with subjects lacking stereo perception (n = 6) and with subjects showing significant unilateral amblyopia with visual acuity in the worse eye <0.5 (n = 7). Fast Fourier Transform was used for analysis of the crude steady-state VEP responses. Compared to normals, the subjects lacking stereo perception showed a significantly lower power of the second harmonic in the response evoked by binocular stimulation with gratings reversed at 15 Hz. The amblyopic group showed a significant difference between the dominant and the non-dominant eye regarding the first harmonic power in the responses evoked by gratings reversed at 5 and 10 Hz. These findings are discussed in relation to the magnocellular and parvocellular visual pathways and suggested models for linear and non-linear processing of visual signals.

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Section: Discussionsupporting

confidence: 59%

“…On the other hand, decreased visual acuity caused by amblyopia should mainly affect the lower frequencies where P pathway is predominant [14]. Furthermore, amblyopia has been found to decrease the amplitude and increase the latency of the transient VEP [15,16].…”

Section: Introductionmentioning

confidence: 99%

Fourier-analysed Steady-state VEPs in Pre-school Children with and without Normal Binocularity

Johansson

Jakobsson

2006

Doc Ophthalmol

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“…These studies have shown reduced cerebral blood flow and glucose metabolism in V1 and extrastriate cortex for amblyopic eye viewing. [21][22][23][24][25][26][27] Nevertheless, these studies have not yielded a consistent answer regarding the spatial extent of the effect, and the relative deficit in V1 versus V2 remains unclear. Most studies have not localized deficits to specific visual areas or field locations, with some exceptions.…”

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confidence: 90%

Monocular activation of V1 and V2 in amblyopic adults measured with functional magnetic resonance imaging

Conner

Odom

Schwartz

et al. 2007

Journal of American Association for Pediatric Ophthalmology and

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“…The significance of each region was estimated using distributional approximations from the theory of Gaussian fields (Worsley et al 1999). We used a direct comparison of homologous with the flipped images in the right-left direction to determine if there was any lateralization in the activity of the M1 or other areas during each task (Mizoguchi et al 2005;Callan et al 2006). We created flipped images of all the PET images and subtracted the flipped contrast images (flipped task image minus the flipped rest image) and non-flipped contrast images (non-flipped task image minus the non-flipped rest image).…”

Section: Data Processing and Statistical Analysesmentioning

confidence: 99%

The Pre-Supplementary and Primary Motor Areas Generate Rhythm for Voluntary Eye Opening and Closing Movements

Suzuki

Kiyosawa

Mochizuki

et al. 2010

Tohoku J. Exp. Med.

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Blinking and opening/closing of the eyelid are considered to be different movements with independent control mechanisms. Apraxia of lid opening (ALO) is a clinical syndrome in which patients experience difficulty in opening their eyes voluntarily. Our previous study with fluorodeoxyglucose and positron emission tomography (PET) has suggested that functional impairments in the supplementary motor area (SMA) and the anterior cingulate gyrus may be involved in the pathophysiology of ALO. The aim of this study was to explore the physiological mechanisms for voluntary eyelid opening/closing and the difference between self-initiated and triggered movements, using [15 O]H 2 O and PET. We measured the regional cerebral blood flow in 8 healthy subjects under 3 conditions: [A] at rest with eyes closed, [B] with self-paced lid opening/closing, and [C] with triggered lid opening/closing. All tasks were done with a blindfold to exclude the influence of visual input. The SMA proper and the angular gyrus were activated during self-paced and triggered lid opening/closing movements; however, the pre-SMA and the primary motor area (M1) were activated only during self-paced movements. The anterior cingulate gyrus and the cerebellum were activated during self-paced condition over triggered condition. The roles of SMA, M1 and cerebellum were assumed in eyelid opening/closing movements: the preparation and processing of movements in SMA, execution of movements in M1, and rhythmic generation in pre-SMA, M1 and cerebellum. We suggest that the activation in pre-SMA, anterior cingulate gyrus, and cerebellum may be responsible for the self-initiated eyelid opening/closing movements.

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Differential activation of cerebral blood flow by stimulating amblyopic and fellow eye

Abstract: The decreased activation of blood flow in the contra-lateral V1 by low temporal frequency stimuli supports the hypothesis that the parvocellular pathway in amblyopic eyes is depressed.

Cited by 25 publications

References 25 publications

Fourier-analysed Steady-state VEPs in Pre-school Children with and without Normal Binocularity

Fourier-analysed Steady-state VEPs in Pre-school Children with and without Normal Binocularity

Monocular activation of V1 and V2 in amblyopic adults measured with functional magnetic resonance imaging

The Pre-Supplementary and Primary Motor Areas Generate Rhythm for Voluntary Eye Opening and Closing Movements

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