Differential Acute Effect of High-Intensity Interval or Continuous Moderate Exercise on Cognition in Individuals With Parkinson’s Disease

Fiorelli, Carolina Menezes; Ciolac, Emmanuel Gomes; Simieli, Lucas; Silva, Fabiana Araújo; Fernandes, Bianca; Christofoletti, Gustavo; Barbieri, Fábio Augusto

doi:10.1123/jpah.2018-0189

Cited by 51 publications

(42 citation statements)

References 43 publications

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“…Exercise improves mobility and increases muscle strength [144]. In addition, exercise therapy in the form of endurance training, resistance training, intensive mixed training, or high-intensity interval training (HIIT) resulted in a reduction of clinical symptoms in PD [145][146][147][148][149][150][151][152]. Long-term resistance and HIIT training reduced muscle tone and stiffness and had a positive effect on body balance in people with PD, osteoarthritis, and AD [153][154][155][156].…”

Section: Study In Humansmentioning

confidence: 99%

BDNF as a Promising Therapeutic Agent in Parkinson’s Disease

Pałasz

Wysocka

Gąsiorowska

et al. 2020

IJMS

341

197

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Brain-derived neurotrophic factor (BDNF) promotes neuroprotection and neuroregeneration. In animal models of Parkinson's disease (PD), BDNF enhances the survival of dopaminergic neurons, improves dopaminergic neurotransmission and motor performance. Pharmacological therapies of PD are symptom-targeting, and their effectiveness decreases with the progression of the disease; therefore, new therapeutical approaches are needed. Since, in both PD patients and animal PD models, decreased level of BDNF was found in the nigrostriatal pathway, it has been hypothesized that BDNF may serve as a therapeutic agent. Direct delivery of exogenous BDNF into the patient's brain did not relieve the symptoms of disease, nor did attempts to enhance BDNF expression with gene therapy. Physical training was neuroprotective in animal models of PD. This effect is mediated, at least partly, by BDNF. Animal studies revealed that physical activity increases BDNF and tropomyosin receptor kinase B (TrkB) expression, leading to inhibition of neurodegeneration through induction of transcription factors and expression of genes related to neuronal proliferation, survival, and inflammatory response. This review focuses on the evidence that increasing BDNF level due to gene modulation or physical exercise has a neuroprotective effect and could be considered as adjunctive therapy in PD.

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Section: Study In Humansmentioning

confidence: 99%

BDNF as a Promising Therapeutic Agent in Parkinson’s Disease

Pałasz

Wysocka

Gąsiorowska

et al. 2020

IJMS

341

197

View full text Add to dashboard Cite

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“…Possible approaches may include reducing mitochondrial activity, potentially with metformin, and/or targeting BCAA metabolism. For example, high-intensity interval training (HIIT) was recently shown to improve motor and cognitive symptoms in PD [ 22 , 23 ], and rats exposed to HIIT had significant alterations in plasma levels of BCAAs [ 24 ], consistent with a protective effect on BCAA metabolism. Moreover, different therapeutic strategies targeting BCAA metabolism or mitochondrial activity may be necessary at different stages of PD, such that specific imbalances are corrected rather than exacerbated, and mitochondrial homeostasis is restored.…”

mentioning

confidence: 99%

Mitochondrial hyperactivity as a potential therapeutic target in Parkinson’s disease

Mor

Murphy

2020

Translational Medicine of Aging

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Mitochondrial dysfunction is thought to contribute to neurodegeneration in Parkinson’s disease (PD), yet the cellular events that lead to mitochondrial disruption remain unclear. Post-mortem studies of PD patient brains and the use of complex I inhibitors to model the disease previously suggested a reduction in mitochondrial activity as a causative factor in PD, but this may represent an endpoint in the disease process. In our recent studies, we identified a novel link between branched-chain amino acid metabolism and PD, and uncovered mitochondrial hyperactivity as a potential alternative mechanism of PD pathogenesis. Increased mitochondrial activity may occur in a subset of PD patients, or may be a more common early event that precedes the ultimate loss of mitochondrial function. Therefore, it may be that any imbalance in mitochondrial activity, either increased or decreased, could cause a loss of mitochondrial homeostasis that leads to disease. An effective therapeutic strategy may be to target specific imbalances in activity at selective stages of PD or in specific patients, with any efforts to reduce mitochondrial activity constituting a surprising new avenue for PD treatment.

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“…Sport-physiological research supports the premise that higher-intensity exercise treatments lead to greater cognitive bene ts compared with moderate-intensity exercise [47]. HIIT has been reported to have a positive effect on improving cognition in the elderly and cognitiveimpairment groups [48][49][50]. Currently, the evidence in favor of high-intensity training for SUD is weak.…”

Section: Introductionmentioning

confidence: 99%

Tai Chi versus High-intensity Interval Training on Inhibitory Control in Individuals with Substance Use Disorder

Pang¹,

Zhu²,

Yang³

et al. 2021

Preprint

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Background Cognitive function of individuals with substance use disorder (SUD) is defective, and higher cognitive inhibitory control ability is considered to be related to lower drug craving. As a conjunction treatment for individuals with SUD, exercise has received supports and attention in many countries recently. Exercise has been reported to be beneficial for cognitive rehabilitation. However, different exercises have different effects on cognitive function. The purpose of this study is to investigate the effects of a single session of Tai chi (TC) exercise and high-intensity interval training (HIIT) on inhibitory control in individuals with SUD. Methods A total 47 individuals with methamphetamine dependence were recruited from a compulsory drug rehabilitation center; participation in this study was voluntary. The participants were randomly assigned to the TC group or the HIIT group, and computer-based Go/No-go and Stroop tasks were used to assess inhibitory control in an indoor setting prior to and following exercise. Independent sample t-test was applied for baseline comparison of continuous variables, while repeated-measures analysis of variance was applied to test differences in the effect of each intervention before and after a single session of exercise. Results In Go/No-go test, the reaction time of the TC and HIIT groups in the post-test was shorter than that at the baseline, and the response accuracy of the post-test were higher than that of the baseline. In the Stroop task, the reaction time of two groups in the post-test was shorter than that at the baseline; while, greater improvement in response accuracy was observed in HIIT group in the post-test than that of the baseline. Conclusion Both TC and HIIT can promote inhibitory control in individuals with SUD. Compared with the TC group, the HIIT group showed greater improvements in response accuracy. These findings demonstrate the potential of TC and HIIT in improving cognition in SUD. Trial registration : ChiCTR1900022158 Chinese Clinical Trial Registry: Registered 27th March, 2019.

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Differential Acute Effect of High-Intensity Interval or Continuous Moderate Exercise on Cognition in Individuals With Parkinson’s Disease

Cited by 51 publications

References 43 publications

BDNF as a Promising Therapeutic Agent in Parkinson’s Disease

BDNF as a Promising Therapeutic Agent in Parkinson’s Disease

Mitochondrial hyperactivity as a potential therapeutic target in Parkinson’s disease

Tai Chi versus High-intensity Interval Training on Inhibitory Control in Individuals with Substance Use Disorder

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