Differential apoptotic response to ionizing radiation in subpopulations of human white blood cells

Ameliorating Effects of Bone Marrow Transplantation and Zinc Supplementation on Physiological and Immunological Changes in γ-Irradiated Rats.

“…Gamma irradiation is an immunosuppressive agent (Kajioka et al, 2000). Adaptive immune system is affected by deficient lymphopoiesis and apoptosis of lymphocytes (Wikins et al 2002).In the present results whole body gamma irradiation (5Gy) causes considerable decrease in the hematological values like RBC WBC and lymphocytes percentage as well as bone marrow lymphocyte, splenocytes and viable BM cells. This decrease is probably an indication of impairment of cell division and obliteration of blood-forming organs (Nunia et al, 2007) besides defective haemopoiesis (Gridley et al, 2001) in addition to their high radiosensetivity (Smart and Kumar ,2003).…”

“…This decrease is probably an indication of impairment of cell division and obliteration of blood-forming organs (Nunia et al, 2007) besides defective haemopoiesis (Gridley et al, 2001) in addition to their high radiosensetivity (Smart and Kumar ,2003). This is followed by thrombocytopenia and concomitant hemorrhages beside the effects in adaptive immune system resulting from apoptosis of lymphocytes and deficient lymphopoiesis (Wikins et al, 2002). Nevertheless, the decrease of RBC count might be attributed to alimentary tract injury, hemorrhage or leakage through capillary walls and/or the direct destruction of mature circulating cells (Ashry et al, 2013).…”

Detection of Radiation-Induced Apoptosis Using the Comet Assay

“…1 shows that a small portion of the DNA remained at the origin, and that the greater portion of the DNA has fragmented and has migrated sufficiently to make the tail. This characteristic image is called a teardrop, pear-shaped, or large fan-like tail [3,16,20,22,34]. It is understood that this finely cut, spread, migrated DNA is indicative of an apoptotic cell.…”

Does Dipyridamole Attenuate Whole Body γ-rays-Induced Oxidative Damage in Male Rats?

“…Wang et al (2006) reported that exposure of C57BL/6 mice to 6.5Gy induced a quantitative and qualitative reduction of haematopoietic stem cells (HSC), resulting from induction of senescence and impairment of HSC self-renewal via activation of the specific cellular pathways. This is complicated by thrombocytopenia and concomitant haemorrhages, besides effects in adaptive immune system resulting from apoptosis of lymphocytes and deficient lymphopoiesis (Wilkins et al, 2002). Ionizing radiation is known to induce oxidative stress through generation of ROS and RNS and resulting in imbalance of the pro-oxidant and antioxidant activities (Srinivasan et al, 2007).…”