Differential association of ESR1 and ESR2 gene variants with the risk of breast cancer and associated features: A case-control study

Ghali, Rabeb M; Al-Mutawa, Maryam A; Al-Ansari, Abrar K.; Zaied, Sonia; Bhiri, Hanen; Mahjoub, Touhami; Almawi, Wassim Y.

doi:10.1016/j.gene.2018.02.011

Cited by 25 publications

(10 citation statements)

References 31 publications

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“…Our conclusion was different from another study that concluded SNP rs4986938 might be associated with BC (7). The present meta-analysis contained 2 updated literatures which coincide with our conclusion (10, 11). Besides, 6 studies published previously also observed no significant association between these gene polymorphisms and susceptibility to BC ( 10, 11, 14, 29–31).…”

Section: Discussionsupporting

confidence: 65%

“…The present meta-analysis contained 2 updated literatures which coincide with our conclusion (10, 11). Besides, 6 studies published previously also observed no significant association between these gene polymorphisms and susceptibility to BC ( 10, 11, 14, 29–31). It is likely that other genetic and environmental factors had influenced BC development (32).…”

Section: Discussionsupporting

confidence: 65%

“…The rs4986938 polymorphisms were in HWE for all studies. Among the 23 studies, 8 were conducted in USA (8, 12–16), 3 in Japan (9, 17), 2 in Sweden (6, 18) and Germany (19, 20), and 1 each in Tunisia (10), Brazil (11), Singapore (21), Iran (22), China (23), Australia (5), France (24) and India (25).…”

Section: Resultsmentioning

confidence: 99%

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No Association between Estrogen Receptor-Β Rs4986938 and Cancer Risk: A Systematic Review and Meta-Analysis

Li¹,

Yang²,

Zhang³

et al. 2019

ijph

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Background: The association between estrogen receptor-β (ESR2) rs4986938 polymorphism and the risk of various types of cancer have been investigated in previous studies. However, the results remained disputable. Here, we conducted a meta-analysis to investigate the association between ESR2 rs4986938 polymorphism and the risk of cancer. Methods: We searched for relevant articles collected by the PubMed, EMBASE, and Cochrane library up to March 30, 2018. The association was assessed using Odds ratios (ORs) and 95% confidence intervals (CIs). Results: The meta-analysis involved a total of 23 studies in 20 papers, including 24,334 cases and 31,707 controls. No significant association was detected between the rs4986938 polymorphism and cancer risk in the additive model (A compared with G: OR=0.97, 95% CI=0.92-1.02, P=0.20), dominant model (AA+AG compared with GG: OR=0.96, 95% CI=0.93-1.03, P=1.00), recessive model (AA compared with AG + GG: OR=0.94, 95% CI=0.86-1.03, P=0.18), heterozygous model (AG compared with GG: OR=0.97, 95% CI=0.94-1.01, P=0.14), and homozygous model (AA compared with GG: OR=0.96, 95% CI=0.87-1.06, P=0.39). Results of subgroup analysis stratified by ethnicity and cancer types further validated the results. Conclusion: We found no evidence of an association between rs4986938 and the risk of overall cancer.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionsupporting

confidence: 65%

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No Association between Estrogen Receptor-Β Rs4986938 and Cancer Risk: A Systematic Review and Meta-Analysis

Li¹,

Yang²,

Zhang³

et al. 2019

ijph

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“…The two forms of estrogen receptor are ERα and ERβ, which are encoded by ESR1 and ESR2, respectively. Alteration of pre-mRNA splicing and expression levels of ESR1 modulate the function of ERα (Ghali et al, 2018). ERβ is homologous to ERα, and these two proteins have similar, but not identical, tissue distributions (Mosselman, Polman, & Dijkema, 1996).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant hesperetin improves the quality of porcine oocytes during aging in vitro

Kim

Lee

Park

et al. 2018

Molecular Reproduction Devel

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The citrus flavonoid hesperetin has a variety of pharmacological actions, including antioxidant, antiinflammatory, and anticancer activities. This study investigated whether hesperetin prevents aging of oocytes in vitro in which it determined the maturation of nuclear and cytoplasm and the developmental capacity of embryo by modulating the reactive oxygen species (ROS) level. Porcine oocytes were matured in vitro for 44 hr (control) and for an additional 24 hr in the presence of 0, 1, 10, 100, and 250 μM hesperetin (aging, H‐1, H‐10, H‐100, and H‐250, respectively). Although there was no difference in the rate of maturation among all the groups, both the control and H‐100 groups significantly increased in the rate of cleavage and blastocyst formation compared to the aging group. The H‐100 group significantly decreased ROS activity and increases the level of glutathione (GSH) and expression of the antioxidant genes (PRDX5, NFE2L, SOD1, and SOD2) compared with the aging group. The H‐100 groups prevented aberrant spindle organization and chromosomal misalignment, blocked the decrease in the level of phosphorylated‐p44/42 mitogen‐activated protein kinase and increased the messenger RNA expression of cytoplasmic maturation factor genes (GDF9, CCNB1, BMP15, and MOS). Subsequently, both the control and H‐100 groups significantly increased the total cell number and decreased the apoptosis cells at the blastocyst stage compared with aging group. The results indicate that hesperetin improves the quality of porcine oocytes by protecting them against oxidative stress during aging in vitro.

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“…The association between rs9340799 (also known as Xbal) and BC risk has been evaluated in several studies before, but the conclusions were debatable. A few studies suggested this polymorphism can affect BC risk [23–25], whereas others did not find any relationship between this polymorphism and BC susceptibility [8, 18, 26, 27]. There is only one previous study of rs9383951and BC risk, but no significant association was found.…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms of estrogen receptor genes are associated with breast cancer susceptibility in Chinese women

et al. 2019

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BackgroundEstrogen exposure is a widely known risk factor for BC. And the interaction of estrogen with estrogen receptor (ER) plays an important role in breast cancer development. This case–control study aims to assess the association of genetic polymorphisms in the estrogen receptor genes with breast cancer (BC) susceptibility in Chinese Han women.MethodsFour polymorphisms (rs2881766, rs9383951, rs9340799 in ESR1 and rs3020449 in ESR2) were genotyped in 459 patients and 549 healthy controls using the Sequenom MassARRAY method. Odds ratio (OR) and 95% confidence intervals (95% CI) were calculated to evaluate the associations. False-positive report probability (FPRP) was utilized to examine the noteworthiness of significant findings.ResultsWe observed that rs2881766 was associated with a decreased BC risk (GG vs. TT: OR = 0.63, 95% CI = 0.44–0.91; GG vs. TT/GT: OR = 0.68, 95% CI = 0.49–0.95), while rs3020449 was associated with an increased risk of BC (CT vs. TT: OR = 1.58, 95% CI = 1.21–2.06; CT/CC vs. TT: OR = 1.54, 95% CI = 1.20–1.98; TT/CC vs. CT: OR = 1.48, 95% CI = 1.15–1.90). The other two polymorphisms have no relation with BC susceptibility. In addition, rs2881766 was correlated with lymph node metastasis and ER expression, and rs3020449 was related to tumor size, histological grade and ER expression. The values of false-positive report probability indicated that the significant associations of BC risk with both rs2881766 and rs3020449 were noteworthy.ConclusionsOur study suggests that polymorphisms rs2881766 and rs3020449 in estrogen receptor genes were associated with BC susceptibility as well as clinical features in Chinese women. These findings need further validation in a large population.Electronic supplementary materialThe online version of this article (10.1186/s12935-019-0727-z) contains supplementary material, which is available to authorized users.

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Differential association of ESR1 and ESR2 gene variants with the risk of breast cancer and associated features: A case-control study

Cited by 25 publications

References 31 publications

No Association between Estrogen Receptor-Β Rs4986938 and Cancer Risk: A Systematic Review and Meta-Analysis

No Association between Estrogen Receptor-Β Rs4986938 and Cancer Risk: A Systematic Review and Meta-Analysis

Antioxidant hesperetin improves the quality of porcine oocytes during aging in vitro

Genetic polymorphisms of estrogen receptor genes are associated with breast cancer susceptibility in Chinese women

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