Differential biochemical responses to metal/metalloid accumulation in organs of an edible fish (Centropomus parallelus) from Neotropical estuaries

Souza, Iara da Costa; Morozesk, Mariana; Bonomo, Marina Marques; Azevedo, Vinícius; Sakuragui, Marise Margareth; Elliott, Michael; Matsumoto, Sílvia Tamie; Wunderlin, Daniel Alberto; Baroni, María Verónica; Monferrán, Magdalena V.; Fernandes, Marisa N.

doi:10.1016/j.ecoenv.2018.05.068

Cited by 34 publications

(9 citation statements)

References 62 publications

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“…The general trend of higher MT concentrations in the fish muscle observed in the present study may be associated with trace metal overload in the liver and other excretory organs (e.g., kidneys), with the excess accumulated in the muscle ( Pacheco et al, 2017 ; Souza et al, 2018 ), suggesting high exposure to the assessed contaminants. However, further monitoring of biomarker expression in fish and trace metal concentrations in fish muscle are required to confirm this hypothesis.…”

Section: Discussionsupporting

confidence: 51%

“…Previous studies have showed synthesis of MTs and GSH in response to exposure of an aquatic animal to toxic elements ( Lavradas et al, 2014 ; Souza et al, 2018 ). Biomarker synthesis was observed in liver, muscle, and kidney tissues that work on the capture, storage, and excretion of toxic elements in a variety of aquatic organisms including mussels, crabs, fish, and marine mammals ( Lavradas et al, 2014 , 2016 ; Souza et al, 2018 ; Monteiro et al, 2019 ). It is noteworthy that similar effects were observed in contaminated freshwater ecosystems in the Rio Doce basin following the Samarco disaster, with fish exhibiting an induction of the proteins and enzymes expression related to contamination and hepatic damage ( Weber et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Contamination and oxidative stress biomarkers in estuarine fish following a mine tailing disaster

Gabriel

Hauser‐Davis

Soares

et al. 2020

PeerJ

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Background The Rio Doce estuary, in Brazil, was impacted by the deposition of iron mine tailings, caused by the collapse of a dam in 2015. Based on published baseline datasets, the estuary has been experiencing chronic trace metal contamination effects since 2017, with potential bioaccumulation in fishes and human health risks. As metal and metalloid concentrations in aquatic ecosystems pose severe threats to the aquatic biota, we hypothesized that the trace metals in estuarine sediments nearly two years after the disaster would lead to bioaccumulation in demersal fishes and result in the biosynthesis of metal-responsive proteins. Methods We measured As, Cd, Cr, Cu, Fe, Mn, Pb, Se and Zn concentrations in sediment samples in August 2017 and compared to published baseline levels. Also, trace metals (As, Cd, Cr, Cu, Fe, Hg, Mn, Pb, Se and Zn) and protein (metallothionein and reduced glutathione) concentrations were quantified in the liver and muscle tissues of five fish species (Cathorops spixii, Genidens genidens, Eugerres brasilianus, Diapterus rhombeus and Mugil sp.) from the estuary, commonly used as food sources by local populations. Results Our results revealed high trace metal concentrations in estuarine sediments, when compared to published baseline values for the same estuary. The demersal fish species C. spixii and G. genidens had the highest concentrations of As, Cr, Mn, Hg, and Se in both, hepatic and muscle, tissues. Trace metal bioaccumulation in fish was correlated with the biosynthesis of metallothionein and reduced glutathione in both, liver and muscle, tissues, suggesting active physiological responses to contamination sources. The trace metal concentrations determined in fish tissues were also present in the estuarine sediments at the time of this study. Some elements had concentrations above the maximum permissible limits for human consumption in fish muscles (e.g., As, Cr, Mn, Se and Zn), suggesting potential human health risks that require further studies. Our study supports the high biogeochemical mobility of toxic elements between sediments and the bottom-dwelling biota in estuarine ecosystems.

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Section: Discussionsupporting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Contamination and oxidative stress biomarkers in estuarine fish following a mine tailing disaster

Gabriel

Hauser‐Davis

Soares

et al. 2020

PeerJ

View full text Add to dashboard Cite

show abstract

“…The general trend of higher MT concentrations in fish muscle observed in the present study may be associated with metal overloading in the liver and other excretory organs (e.g. kidneys), where excess metals accumulate in muscle (Pacheco et al, 2017;Souza et al, 2018), suggesting elevated exposure to the assessed contaminants. However, further monitoring of biomarker expression in fish and trace metal concentrations in fish muscle are required to confirm this hypothesis.…”

Section: Discussionsupporting

confidence: 49%

“…Tissues like the liver, with a higher lipid content, can alert about the current accumulation of metals since the metals can reach it very quickly through the bloodstream after absorption and, thus, these concentrations are proportional to those present in the environment (Dural, Göksu & Özak, 2007;Lima-Júnior et al, 2012, , Bosco-Santos & Luiz-Silva, 2020. Increased concentrations of metals in muscle tissue were in bottom-dwelling species C. spixii and G. genidens, may suggest a saturation response for metal and metalloid contamination (Lu et al, 2018;Souza et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Metal contamination and oxidative stress biomarkers in estuarine fish following a mine tailing disaster

Gabriel

Hauser‐Davis

Soares

et al. 2020

Preprint

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AbstractThe Rio Doce estuary in Brazil was impacted by the deposition of mine tailings caused by the collapse of a mining dam in 2015. Since the disaster, the estuary is experiencing chronic trace metal contamination effects, but potential trace metal accumulation in fishes has not been reported. Trace metals in aquatic ecosystems pose severe threats to the aquatic biota, so we hypothesized that the accumulation of trace metals in estuarine sediments nearly two years after the disaster would cause contaminant bioaccumulation, resulting in the biosynthesis of metal-responsive proteins in fishes. We determined trace metal concentrations in sediment samples, metal concentrations, and quantified stress protein concentrations in the liver and muscle tissue of five different fish species in the estuary. Our results revealed high concentrations of trace metals in estuarine sediments when compared to published baseline values for this estuary. The demersal fish species Cathorops spixii and Genidens genidens had the highest Hg, As, Se, Cr, and Mn concentrations in both hepatic and muscle tissues. Metal bioaccumulation in fish was statistically correlated with the biosynthesis of metallothionein and reduced glutathione in both fish liver and muscle tissue. The trace metals detected in fish tissues resemble those in the contaminated sediments present at the estuary at the time of this study and were also significantly correlated to protein levels. Trace metals in fish muscle were above the maximum permissible limits for human consumption, suggesting potential human health risks that require further determination. Our study supports the high biogeochemical mobility of trace metals between contaminated sediments and local biota in estuarine ecosystems.

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“…Accordingly, such objectives require constantly evaluating water quality by means of biomonitoring. Fish, mollusks and invertebrates are extensively used as bioindicators of metal pollution (Van Praet et al, 2014;Wang and Lu, 2017;Bouzahouane et al, 2018;Souza et al, 2018), although aquatic plants are also increasingly being investigated for these ecological surveys (Ferrat et al, 2003;Krayem et al, 2016;Reale et al, 2016). More specifically, the analyses of association, composition and richness of plant species during in situ studies have become even more widespread and in depth.…”

Section: Introductionmentioning

confidence: 99%

Comparative in vitro/in situ approaches to three biomarker responses of Myriophyllum alterniflorum exposed to metal stress

et al. 2019

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Differential biochemical responses to metal/metalloid accumulation in organs of an edible fish (Centropomus parallelus) from Neotropical estuaries

Cited by 34 publications

References 62 publications

Contamination and oxidative stress biomarkers in estuarine fish following a mine tailing disaster

Contamination and oxidative stress biomarkers in estuarine fish following a mine tailing disaster

Metal contamination and oxidative stress biomarkers in estuarine fish following a mine tailing disaster

Comparative in vitro/in situ approaches to three biomarker responses of Myriophyllum alterniflorum exposed to metal stress

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