Differential blood flow in uterine, ophthalmic, and brachial arteries of preeclamptic women*1

Takata, Masashi; Nakatsuka, Mikiya; Kudo, Takafumi

doi:10.1016/s0029-7844(02)02244-5

Cited by 62 publications

(36 citation statements)

References 25 publications

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“…5,8,19 However, when compared with other studies, the mean RI values in our series were similar to those described for women in the third trimester of pregnancy. 7,9,20 In our study, the mean PR was 0.58 6 0.10, which is very similar to values obtained in healthy young adult males 21 and in women more than 20 weeks pregnant. 22 Other studies have reported that no change occurs in the PR as gestation advances beyond 20 weeks.…”

Section: Discussionsupporting

confidence: 90%

Reference values of maternal ophthalmic artery doppler variables in the first trimester of normal pregnancy

Alves

Yang

Sousa

et al. 2014

J of Clinical Ultrasound

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Section: Discussionsupporting

confidence: 90%

Reference values of maternal ophthalmic artery doppler variables in the first trimester of normal pregnancy

Alves

Yang

Sousa

et al. 2014

J of Clinical Ultrasound

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“…27,28 The mean ophthalmic artery Doppler variables identified in this study are broadly in keeping with the reference ranges derived in healthy pregnant populations elsewhere. 21,[29][30][31][32][33][34][35][36][37][38] A summary of the findings of these studies which report the means of key Doppler variables is presented in Table 6, alongside the findings of the present study for comparison.…”

Section: Discussionmentioning

confidence: 91%

Optic nerve sonography and ophthalmic artery Doppler velocimetry in healthy pregnant women: an Australian cohort study

Kane

Dennis

Costa

et al. 2019

J of Clinical Ultrasound

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Purpose Maternal ocular sonography offers a window into cerebrovascular and intracranial pressure changes in pregnancy. This study aimed to determine the Doppler velocimetric variables of the ophthalmic artery, and the mean diameter of the optic nerve sheath (ONSD), in an Australian cohort of healthy pregnant women. Methods A prospective observational cohort study of healthy women with uncomplicated singleton pregnancies in the third trimester was undertaken in a tertiary maternity service. A single prenatal ultrasonographic examination was performed on all participants, with a postnatal examination performed on a subgroup with uncomplicated deliveries. Results Fifty women were examined at a mean gestation of 35 weeks. The mean ± SD Doppler variables in the ophthalmic artery were peak systolic velocity (PSV) 41.89 ± 13.13 cm/s, second peak velocity 20.63 ± 8.97 cm/s, end diastolic velocity 9.29 ± 5.13 cm/s, pulsatility index 1.97 ± 0.53, resistive index 0.78 ± 0.07, peak ratio (second peak velocity/PSV) 0.49 ± 0.12, while the mean ONSD was 4.34 ± 0.4 mm. None of these variables had a demonstrable relationship with gestation or mean arterial pressure (MAP), nor did the sheath diameter have a relationship with any of the Doppler variables. Conclusions The ocular sonographic variables observed in this population are similar to those reported in other cohorts. No clear relationship could be identified in this cohort between ophthalmic artery Doppler variables and the ONSD, and between each of these variables and gestation or MAP.

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“…Excluding one study that observed a very large effect 33 resulted in a slight reduction in the SMD (−1.20, 95% CI: −1.70, −0.70, p<0.001) and heterogeneity (Q=80.6, p<0.001, I 2 =86%). The magnitude of the overall effect was attenuated in sensitivity analyses of studies that excluded smokers (SMD: −1.30, 95% CI:−1.94, −0.66, p<0.001), 23, 30, 32, 34–36, 39–41 women with chronic hypertension (SMD: −1.15, 95% CI: −1.64, −0.66, p<0.001) 30–32, 36–40 or both (SMD: −1.30, 95% CI:−2.05, −0.55, p<0.001). 30, 32, 36, 39, 40 Selecting different time points for one study that included multiple time points 23 did not alter the results.…”

Section: Resultsmentioning

confidence: 98%

“…FMD was significantly lower in women with less severe forms of preeclampsia 31, 34, 36, 37, 39 compared to women who had normotensive pregnancies (SMD: −0.95, 95% CI: −1.30, −0.59, p<0.001, Figure S2, Panel A). Similar results were observed in studies examining women with more severe forms of preeclampsia 31, 34, 36, 39 compared to women who had normotensive pregnancies (SMD: −1.74, 95% CI: −2.65, −0.83, p<0.001, Figure S2, Panel B).…”

Section: Resultsmentioning

confidence: 98%

Impaired Flow-Mediated Dilation Before, During, and After Preeclampsia

et al. 2016

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Endothelial dysfunction is believed to play a critical role in preeclampsia, however it is unclear whether this dysfunction precedes the pregnancy or is caused by early pathophysiological events. It is also unclear for how long vascular dysfunction may persist post-partum, and whether it represents a mechanism linking preeclampsia with future cardiovascular disease. Our objective was to determine whether women with preeclampsia have worse vascular function compared to women who did not have preeclampsia by performing systematic review and meta-analysis of studies that examined endothelial dysfunction using flow-mediated dilation (FMD). We included studies published before May 29, 2015 that examined FMD before, during and after preeclampsia. Differences in FMD between study groups were evaluated by standardized mean differences. Out of 610 abstracts identified through PubMED, EMBASE and Web of Science, 37 studies were eligible for the meta-analysis. When compared to women who did not have preeclampsia, women who had preeclampsia had lower FMD prior to the development of preeclampsia (~20–29 weeks gestation), at the time of preeclampsia, and for three years post-partum, with the estimated magnitude of the effect ranging between 0.5 and 3 standard deviations. Similar effects were observed when the analysis was limited to studies that excluded women with chronic hypertension, smokers, or both. Vascular dysfunction predates preeclampsia and may contribute to its pathogenesis. Future studies should address whether vascular changes that persist after preeclamptic pregnancies may represent a mechanistic link with the increased risk for future cardiovascular disease.

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Differential blood flow in uterine, ophthalmic, and brachial arteries of preeclamptic women*1

Abstract: Ultrasound evaluation of uterine and orbital circulation and flow-mediated vasodilation of the brachial artery helps differentiate the degree and severity of preeclampsia.

Cited by 62 publications

References 25 publications

Reference values of maternal ophthalmic artery doppler variables in the first trimester of normal pregnancy

Reference values of maternal ophthalmic artery doppler variables in the first trimester of normal pregnancy

Optic nerve sonography and ophthalmic artery Doppler velocimetry in healthy pregnant women: an Australian cohort study

Impaired Flow-Mediated Dilation Before, During, and After Preeclampsia

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