Differential Carbon Dioxide Sensitivity in Childhood Anxiety Disorders and Nonill Comparison Group

Pine, Daniel S.; Klein, Rachel G.; Coplan, Jeremy D.; Papp, Laszlo A.; Hoven, Christina W.; Martı́nez, José M.; Kovalenko, Pavel; Mandell, Donald J.; Moreau, Donna; Klein, Donald F.; Gorman, Jack M.

doi:10.1001/archpsyc.57.10.960

Cited by 125 publications

(98 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prior studies show that youth with internalizing disorders differ from healthy peers on measures of neural activation in response to threat cues (McClure et al, 2007;C. S. Monk et al, 2006), cardiac functioning (C. Monk et al, 2001), and respiratory functioning (Pine et al, 2000); consequently, such data gathered in the context of the PD game could prove informative. Examination of interactions between sex and diagnostic status for physiological responses also appears warranted in future research, given that heightened sensitivity to social stress is evident in females at physiological, as well as at behavioral and emotional, levels.…”

Section: Resultsmentioning

confidence: 99%

“…Second, anxiety and depression relate similarly to social difficulty among adolescents (La Greca, 2005). Finally, the convention of grouping youth with anxiety disorders together has been employed by the Research Units for Pediatric Psychopharmacology (RUPP) Anxiety Study and other randomized controlled treatment trials for pediatric anxiety disorders (Birmaher et al, 2003;Kendall et al, 1997), as well as neurobiological studies of pediatric anxiety disorders (Pine et al, 2000).…”

Section: Participantsmentioning

confidence: 99%

See 1 more Smart Citation

Responses to Conflict and Cooperation in Adolescents with Anxiety and Mood Disorders

McClure

Parrish

Nelson

et al. 2007

J Abnorm Child Psychol

Self Cite

View full text Add to dashboard Cite

This study examined patterns of behavioral and emotional responses to conflict and cooperation in adolescents with anxiety/mood disorders and healthy peers. We compared performance on and emotional responses to the Prisoner's Dilemma (PD) game, an economic exchange task involving conflict and cooperation, between adolescents with anxiety/depressive disorders (A/D) (N=21) and healthy comparisons (n=29). Participants were deceived to believe their co-player (a pre-programmed computer algorithm) was another study participant. A/D adolescents differed significantly from comparisons in patterns of play and emotional response to the game.Specifically, A/D participants responded more cooperatively to cooperative overtures from their co-players; A/D girls also reported more anger toward co-players than did comparison girls. Our findings indicate that A/D adolescents, particularly females, respond distinctively to stressful social interchanges. These findings offer a first step toward elucidating the mechanisms underlying social impairment in youth with internalizing disorders.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

Responses to Conflict and Cooperation in Adolescents with Anxiety and Mood Disorders

McClure

Parrish

Nelson

et al. 2007

J Abnorm Child Psychol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Nicotine addiction and related withdrawal symptoms can lead to an increased number of psychological symptoms, including anxiety and depression (West & Hajek, 1997). Additionally, the impaired respiratory functioning associated with smoking such as wheezing and shortness of breath (Moore, Augustson, Moser, & Budney, 2005) and the anxiogenic effects of sustained nicotine intake can give rise to symptoms of anxiety (Pine et al, 2000;West & Hajek, 1997).…”

Section: Discussionmentioning

confidence: 99%

Unexpected Benefits: Pathways From Smoking Restrictions in the Home to Psychological Well-Being and Distress Among Urban Black and Puerto Rican Americans

Pahl

Brook

Koppel

et al. 2011

Nicotine & Tobacco Research

View full text Add to dashboard Cite

“…This can be experimentally reproduced in adult panic sufferers, but also in children with separation anxiety disorder (Pine et al 2000;Preter and Klein, 2008).…”

Section: Panic and Comorbid Conditionsmentioning

confidence: 95%

Lifelong Opioidergic Vulnerability Through Early Life Separation: A Recent Extension of the False Suffocation Alarm Theory of Panic Disorder

Preter¹

2016

Panic Disorder

View full text Add to dashboard Cite

We briefly reference previous material on Klein's suffocation false alarm theory (SFA) of panic disorder (Klein, 1993) and its amplification in 2008 (Preter andKlein, 2008). We then discuss a recent finding showing a fundamental difference in opioidergic reactivity to a naloxone challenge in psychiatrically and medically healthy adults, based on the presence or absence of childhood separation/parental loss.In 1993, Klein published the original SFA theory of panic disorder (Klein, 1993), attempting to integrate the multiplicity of apparently unrelated clinical and laboratory observations. We posited "that a physiologic misinterpretation by a suffocation monitor misfires an evolved suffocation alarm system. This produces sudden respiratory distress followed swiftly by a brief hyperventilation, panic, and the urge to flee. Carbon dioxide hypersensitivity is seen as due to the deranged suffocation alarm monitor. If other indicators of potential suffocation provoke panic, this theoretical extension is supported." In the original paper, we tested "the theory by examining Ondine's curse as the physiologic and pharmacologic converse of panic disorder, splitting panic in terms of symptomatology and challenge studies, reevaluating the role of hyperventilation, and reinterpreting the contagiousness of sighing and yawning, as well as mass hysteria." (Klein, 1993) Original SFA focused on relating the observed lactate and carbon dioxide hypersensitivity in panic disorder to a putative dysfunction in a hypothesized suffocation alarm. At the time, the underlying pathophysiology that might connect the apparent disparate "phenomena of panic during relaxation and sleep, late luteal phase dysphoric disorder, pregnancy, childbirth, pulmonary disease, separation anxiety, and treatment", was unknown.

show abstract

Differential Carbon Dioxide Sensitivity in Childhood Anxiety Disorders and Nonill Comparison Group

Cited by 125 publications

References 47 publications

Responses to Conflict and Cooperation in Adolescents with Anxiety and Mood Disorders

Responses to Conflict and Cooperation in Adolescents with Anxiety and Mood Disorders

Unexpected Benefits: Pathways From Smoking Restrictions in the Home to Psychological Well-Being and Distress Among Urban Black and Puerto Rican Americans

Lifelong Opioidergic Vulnerability Through Early Life Separation: A Recent Extension of the False Suffocation Alarm Theory of Panic Disorder

Contact Info

Product

Resources

About