Differential changes in cell size and number in topographic subdivisions of human basal nucleus in normal aging

Lacalle, Sonsoles de; Iráizoz, I.; Gonzalo, L.M.

doi:10.1016/0306-4522(91)90307-a

Cited by 97 publications

(38 citation statements)

References 35 publications

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“…Ch4 group (Figs 1C-E, 3A, 4-6)-Cell aggregates in the subpallidal region, largely correspond to the basal nucleus of Meynert as defined by Vogels et al, (1990) andDe Lacalle et al, (1991). We did not differentiate subcomponents of the Ch4 compartment as suggested by Mesulam et al, (1983).…”

Section: Ch3 Group (Figs 1b 3a-b)-thementioning

confidence: 81%

“…Estimations of the neuronal loss of basal nucleus of Meynert during normal aging also vary greatly from 23% to 50% to no neuronal loss at all (Whitehouse et al, 1981;Chui et al, 1984;De Lacalle et al, 1991). In addition to Alzheimer's disease, there are structural changes in the basal forebrain occasionally in Parkinson's disease, Rett syndrome, progressive supranuclear palsy, Parkinson dementia complex of Guam, dementia pugilistica, Pick's disease, Korsakoff's syndrome, Down syndrome, Wernicke's encephalopathy, and Cretuzfeldt-Jacob disease (reviewed in Swaab, 2003).…”

Section: Age and Disease-related Changes In The Magnocellular Basal Cmentioning

confidence: 99%

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Stereotaxic probabilistic maps of the magnocellular cell groups in human basal forebrain

et al. 2008

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The basal forebrain contains several interdigitating anatomical structures, including the diagonal band of Broca, the basal nucleus of Meynert, the ventral striatum, and also cell groups underneath the globus pallidus that bridge the centromedial amygdala to the bed nucleus of the stria terminalis. Among the cell populations, the magnocellular, cholinergic corticopetal projection neurons have received particular attention due to their loss in Alzheimer's disease. In MRI images, the precise delineation of these structures is difficult due to limited spatial resolution and contrast. Here, using microscopic delineations in ten human postmortem brains, we present stereotaxic probabilistic maps of the basal forebrain areas containing the magnocellular cell groups. Cytoarchitectonic mapping was performed in silver stained histological serial sections. The positions and the extent of the magnocellular cell groups within the septum (Ch1-2), the horizontal limb of the diagonal band (Ch3), and in the sublenticular part of the basal forebrain (Ch4) were traced in high-resolution digitized histological sections, 3D reconstructed, and warped to the reference space of the MNI single subject brain. The superposition of the cytoarchitectonic maps in the MNI brain shows the intersubject variability of the various Ch compartments and their stereotaxic position relative to other brain structures. Both the right and left Ch4 regions showed significantly smaller volumes when age was considered as a covariate. Probabilistic maps of compartments of the basal forebrain magnocellular system are now available as an open source reference for correlation with fMRI, PET, and structural MRI data of the living human brain.

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Section: Ch3 Group (Figs 1b 3a-b)-thementioning

confidence: 81%

Section: Age and Disease-related Changes In The Magnocellular Basal Cmentioning

confidence: 99%

Stereotaxic probabilistic maps of the magnocellular cell groups in human basal forebrain

et al. 2008

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“…D. Aging is associated with 30-50% decline in number of cholinergic neurons in the NBM of rats (Smith and Booze, 1995) and humans (de Lacalle et al, 1991;Guela and Mesulam, 1994).…”

Section: Amentioning

confidence: 99%

Lesion of cholinergic neurons in nucleus basalis enhances response to general anesthetics

Leung

Petropoulos

Shen

et al. 2011

Experimental Neurology

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"Lesion of cholinergic neurons in nucleus basalis enhances response to general anesthetics" (2011). Physiology and Pharmacology Publications. 72. https://ir.lib.uwo.ca/physpharmpub/72 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues.Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. Acetylcholine in the brain has been associated with consciousness and general anesthesia effects. We tested the hypothesis that the integrity of the nucleus basalis magnocellularis (NBM) affects the response to general anesthetics. Cholinergic neurons in NBM were selectively lesioned by bilateral infusion of 192IgG-saporin in adult, male Long-Evans rats, and control rats were infused with saline. Depletion of choline-acetyltransferase (ChAT)-immunoreactive cells in the NBM and decrease in optical density of acetylcholinesterase (AChE) staining in the frontal and visual cortices confirmed a significant decrease in NBM cholinergic neurons in lesioned as compared to control rats. AChE staining in the hippocampus and ChAT-positive neurons in the medial septum-vertical limb of the diagonal band were not different between lesioned and control rats. When a general anesthetic was administered, lesioned compared to control rats showed significantly longer duration of loss of righting reflex (LORR) after propofol (5 or 10 mg/kg i.v.), pentobarbital (20 or 40 mg/kg i.p.) but not halothane (2%). However, the behavioral excitation, as indicated by horizontal movements, induced by halothane was reduced in lesioned as compared to control rats. Reversible inactivation of NBM with GABA A receptor agonist muscimol increased slow waves in the neocortex during awake immobility, and prolonged the duration of LORR and loss of tail-pinch response after propofol, pentobarbital and halothane. In summary, lesion of NBM cholinergic neurons or inactivation of the NBM prolonged the LORR response to general anesthetic drugs.

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“…Thus there is no agreement regarding the different parameters currently under study, e.g., neuronal size, extension of the dendritic tree, or the number of synapses per cell (Curcio and Hinds, 1983;Coleman and Flood, 1986;Markus et al, 1987;Flood and Coleman, 1988;de Lacalle et al, 1991;Crespo et al, 1992;Stroessner-Johnson et al, 1992;Flood and Coleman, 1993;Peinado et al, 1993;Rance et al, 1993). Similarly, it is argued whether or not neuronal loss occurs during old age (Diamond et al, 1977;Curcio and Coleman, 1982;Satorre et al, 1985;Sturrock, 1989).…”

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confidence: 99%

Quantitative morphological changes in neurons from the dorsal lateral geniculate nucleus of young and old rats

et al. 1997

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Background: We studied the morphological changes occurring in neurons from the dorsal lateral geniculate nucleus (dLGN) during aging by analysing the size and shape of cell bodies and nuclei.Methods: Male albino Wistar rats, aged 3, 18, 24, and 30 months, were used. After appropriate tissue preparation and following the usual histological procedure, the profiles of 1,920 neuronal bodies and nuclei were drawn using a camera lucida. Data was later recorded and processed with a semiautomatic image analyser.Results and conclusions: We observed that dLGN neurons do not change in size from the age of 3-24 months. Between 24 and 30 months, the soma and nucleus of the cell undergo hypertrophy, 32.8% and 35.6%, respectively, when compared to those from 3-month-old animals (P F 0.01). Furthermore, we found a high correlation between cell body size/nucleus size, which does not disappear with age. The r values (correlation coefficient) were 0.7998, 0.8662, 0.8433 and 0.7304, and R 2 (determination coefficient) was equal to 0.6397, 0.7504, 0.7112, and 0.5335. These latter values show that in 63.97%, 75.04%, 71.12%, and 53.35% of cases, respectively, modifications in somata size were accompanied by similar changes in nucleus size, and vice-versa. The study of the shape of the soma and nucleus of the cell revealed that both structures have a rounded-oval configuration that does not change in a significant way from adulthood to old age. Anat.

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Differential changes in cell size and number in topographic subdivisions of human basal nucleus in normal aging

Cited by 97 publications

References 35 publications

Stereotaxic probabilistic maps of the magnocellular cell groups in human basal forebrain

Stereotaxic probabilistic maps of the magnocellular cell groups in human basal forebrain

Lesion of cholinergic neurons in nucleus basalis enhances response to general anesthetics

Quantitative morphological changes in neurons from the dorsal lateral geniculate nucleus of young and old rats

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