Differential clinicopathological and molecular features within late-onset colorectal cancer according to tumor location

Brandáriz, Lorena; Arriba, María; Garcı́a, Juan Luis; Cano, Juana María; Rueda, Daniel; Rubio, Eduardo Díaz; Rodríguez, Yolanda; Pérez, Javier Bajo; Vivas, Alfredo; Sánchez, C. Rodríguez; Tapial, Sandra; Peña, Laura; García‐Arranz, Mariano; Garcı́a-Olmo, Damián; Urioste, Miguel; González-Sarmiento, Rogelio; Perea, José

doi:10.18632/oncotarget.24502

Cited by 7 publications

(6 citation statements)

References 27 publications

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“…In the most novel aspect of this work, the analysis of survival, the results obtained in overall survival, always higher in the RCC group, are comparable to those described in previous studies [ 22 ]. As for the breakdown by stages, there are articles published [ 26 ] that observe that this difference is independent of the tumor stage or that these differences are only significant in stage III in favor of LCC [ 14 , 27 ].…”

Section: Discussionsupporting

confidence: 87%

“…Stratifying CRC according to the criteria of location and age of onset is important and transcendental not only because it correlates with the resulting molecular-based categories, which were described in the 1990s [ 8 ] but also because, with confirmation in larger studies, new therapeutic algorithms can be defined according to their subclassification [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

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Right and Left Colorectal Cancer: Differences in Post-Surgical-Care Outcomes and Survival in Elderly Patients

Fernández¹,

Velasco

Luque³

et al. 2021

Cancers

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(1) There is evidence of the embryological, anatomical, histological, genetic and immunological differences between right colon cancer (RCC) and left colon cancer (LCC). This research has the general objective of studying the differences in outcome between RCC and LCC. (2) A longitudinal analytical study with prospective follow-up of the case–control type was conducted from 1 January 2010 to 31 December 2017 including 398 patients with 1:1 matching, depending on the location of the tumor. Inclusion criteria: programmed colectomies, 15 cm above the anal margin, adults and R0 surgery. (3) Precisely 6.8% of the exitus occurred in the first 6 months of the intervention. At 6 months, patients with LCC presented a mean survival of 7 months higher than RCC (p = 0.028). In the first stages, it can be observed that most of the exitus are for patients with RCC (stage I p = 0.021, stage II p = 0.014). In the last stages, the distribution of the deaths does not show differences between locations (stage III p = 0.683, stage IV p = 0.898). (4) The results show that RCC and LCC are significantly different in terms of evolution, progression, complications and survival. Patients with RCC have a worse prognosis, even in the early stages of the disease, due to more advanced N stages, larger tumor size, more frequently poorly differentiated tumors and a greater positivity of lymphovascular invasion than LCC.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Right and Left Colorectal Cancer: Differences in Post-Surgical-Care Outcomes and Survival in Elderly Patients

Fernández¹,

Velasco

Luque³

et al. 2021

Cancers

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“…[31][32][33] Accumulating evidence demonstrate that associations between genetic alterations including CNVs and CRC risk differ for right-sided colon cancer and left-sided colon cancer (including rectal carcinomas), suggesting that carcinogenetic mechanism and progression of CRC may differ with tumor location. [36][37][38] In our study, we observed that the risk of colon and rectal cancers is different for CYLD and USP9X, which may provide the similar conclusion that different genetic pathways of carcinogenesis exit in right and left-sided colon cancer. In our study, we did not observe a significant association between CNVs of USP9X and prognosis of CRC.…”

Section: Discussionsupporting

confidence: 71%

Copy number variation of ubiquitin- specific proteases genes in blood leukocytes and colorectal cancer

Tian

Liu

et al. 2020

Cancer Biology & Therapy

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Ubiquitin-specific proteases (USPs) play important roles in the regulation of many cancer-related biological processes. USPs copy number variation (CNVs) may affect the risk and prognosis of colorectal cancer (CRC). We detected CNVs of USPs genes in 468 matched CRC patients and controls, estimated the associations between the USPs genes CNVs and CRC risk and prognosis and their interactions with environmental factors on CRC risk. Finally, we generated five CRC risk predictive models with different CNVs patterns combining with environmental factors (EF). We identified significant association between CYLD deletion and CRC risk (OR adj = 4.18, 95% CI: 2.03-8.62), significant association between USP9X amplification and CRC risk (OR adj = 2.30, 95% CI: 1.48-3.57), and significant association between USP11 deletion and CRC risk (OR adj = 3.49, 95% CI: 1.49-8.64). There were significant gene-environment and gene-gene interactions on CRC risk. The area under the receiver operating characteristic curve (AUC) of EF + SIG (deletion of CYLD and USP11, amplification of USP9X) model was significantly larger than any other models (AUC = 0.75, 95% CI: 0.74-0.77). We did not identify significant associations between CNVs of the three genes and CRC prognosis. CNVs of CYLD, USP9X, and USP11 are significantly associated with the risk of CRC. Genegene and gene-environment interactions might also play an important role in the development of CRC.

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“…Clinical and molecular features of global LOCRC and comparison between colon locations have been published before [ 4 , 9 , 10 , 11 ], and are summarized in Table 1 , Table 2 and Table 3 . The least frequent location was left colon (23%), whereas the other two locations were observed at equivalent rates.…”

Section: Resultsmentioning

confidence: 99%

“…Subclassification according to the age of onset and tumor location may have applications in terms of diagnosis, prevention and therapy. We recently published differential features for EOCRC and LOCRC separately, according to tumor location, and some interesting subsets within these age-of-onset groups became manifest [ 9 , 11 ]. More interesting, however, was the possibility that both factors, age of onset and colon location may differentiate CRC.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Molecular Comparative Study of Colorectal Cancer Based on Age-of-Onset and Tumor Location: Two Main Criteria for Subclassifying Colorectal Cancer

Álvaro

Cano

Garcı́a

et al. 2019

IJMS

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Our aim was to characterize and validate that the location and age of onset of the tumor are both important criteria to classify colorectal cancer (CRC). We analyzed clinical and molecular characteristics of early-onset CRC (EOCRC) and late-onset CRC (LOCRC), and we compared each tumor location between both ages-of-onset. In right-sided colon tumors, early-onset cases showed extensive Lynch syndrome (LS) features, with a relatively low frequency of chromosomal instability (CIN), but a high CpG island methylation phenotype. Nevertheless, late-onset cases showed predominantly sporadic features and microsatellite instability cases due to BRAF mutations. In left colon cancers, the most reliable clinical features were the tendency to develop polyps as well as multiple primary CRC associated with the late-onset subset. Apart from the higher degree of CIN in left-sided early-onset cancers, differential copy number alterations were also observed. Differences among rectal cancers showed that early-onset rectal cancers were diagnosed at later stages, had less association with polyps, and more than half of them were associated with a familial LS component. Stratifying CRC according to both location and age-of-onset criteria is meaningful, not only because it correlates the resulting categories with certain molecular bases, but with the confirmation across larger studies, new therapeutical algorithms could be defined according to this subclassification.

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Differential clinicopathological and molecular features within late-onset colorectal cancer according to tumor location

Cited by 7 publications

References 27 publications

Right and Left Colorectal Cancer: Differences in Post-Surgical-Care Outcomes and Survival in Elderly Patients

Right and Left Colorectal Cancer: Differences in Post-Surgical-Care Outcomes and Survival in Elderly Patients

Copy number variation of ubiquitin- specific proteases genes in blood leukocytes and colorectal cancer

Clinical and Molecular Comparative Study of Colorectal Cancer Based on Age-of-Onset and Tumor Location: Two Main Criteria for Subclassifying Colorectal Cancer

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