Differential contributions of central and effector memory T cells to recall responses

Roberts, Alan D.; Ely, Kenneth H.; Woodland, David L.

doi:10.1084/jem.20050137

Cited by 252 publications

(290 citation statements)

References 48 publications

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“…Further analysis of CD8 + T cell phenotype showed that there was no difference within percentage of Tcm and Tem/Teff cells between the different PLGA NP immunized groups, but an enhanced ratio of CD8 + T cells with CD44 int phenotype was detected in mice immune to rLM-OVA challenge. Thus, although no clear definition of CD44 int CD62L neg is available [48][49][50], we show a correlation between their presence and intradermal immunization-induced protective immunity to challenge with rLM-OVA.…”

Section: Discussionmentioning

confidence: 56%

Hollow microneedle-mediated intradermal delivery of model vaccine antigen-loaded PLGA nanoparticles elicits protective T cell-mediated immunity to an intracellular bacterium

Groot

Mönkäre

et al. 2017

Journal of Controlled Release

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A B S T R A C TThe skin is an attractive organ for immunization due to the presence of a large number of epidermal and dermal antigen-presenting cells. Hollow microneedles allow for precise and non-invasive intradermal delivery of vaccines. In this study, ovalbumin (OVA)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles with and without TLR3 agonist poly(I:C) were prepared and administered intradermally by hollow microneedles. The capacity of the PLGA nanoparticles to induce a cytotoxic T cell response, contributing to protection against intracellular pathogens, was examined. We show that a single injection of OVA-loaded PLGA nanoparticles, compared to soluble OVA, primed both adoptively transferred antigen-specific naïve transgenic CD8 + and CD4 + T cells with markedly high efficiency. Applying a triple immunization protocol, PLGA nanoparticles primed also endogenous OVA-specific CD8 + T cells. Immune response, following immunization with in particular anionic PLGA nanoparticles co-encapsulated with OVA and poly(I:C), provided protection against a recombinant strain of the intracellular bacterium Listeria monocytogenes, secreting OVA. Taken together, we show that PLGA nanoparticle formulation is an excellent delivery system for protein antigen into the skin and that protective cellular immune responses can be induced using hollow microneedles for intradermal immunizations.

show abstract

Section: Discussionmentioning

confidence: 56%

Hollow microneedle-mediated intradermal delivery of model vaccine antigen-loaded PLGA nanoparticles elicits protective T cell-mediated immunity to an intracellular bacterium

Groot

Mönkäre

et al. 2017

Journal of Controlled Release

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“…Most would accept that a proportion of the T CM precursors must have the capacity to become fully functional effector and͞or T EM cells after secondary challenge (4,5,14). Some studies support the view that a T EM 3T CM transition is possible, both during the acute response and in long-term memory (4,14).…”

mentioning

confidence: 91%

“…Current thinking is focused on the idea that both human and mouse memory T cells can be classified into distinct central memory (T CM ) and effector memory (T EM ) sets (1)(2)(3)(4)(5). Whereas the T CM lymphocytes are CD62L hi , which means that these T cells transit directly from blood to lymph nodes via the high endothelial venules (6,7), the more ''activated'' CD62L lo T EM set accesses the nodes only via afferent lymph and is widely dispersed in a broad range of somatic tissues (8,9).…”

mentioning

confidence: 99%

Early establishment of diverse T cell receptor profiles for influenza-specific CD8⁺CD62L^himemory T cells

Kedzierska

Venturi

Field

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

103

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Single-cell analysis of endogenous, primary CD8 ؉ T cell responses to the influenza D b NP366 and D b PA224 epitopes indicates that prominent clonotypes bearing ''public'' or ''shared'' T cell receptors (TCRs) subset early into CD62L hi and CD62L lo populations. The CD62L lo effectors divide more and are rapidly eliminated during the contraction phase, whereas stable CD62L hi memory populations persist in the long-term. Reflecting the high frequency of small CD62L hi clones expressing ''private'' TCRs, the TCR diversity range per mouse is generally two times higher within the CD62L hi CD8 ؉ D b NP366 ؉ set (1.6 times higher for CD62L hi CD8 ؉ D b PA224 ؉ ) from 8 to >180 days after antigen challenge. Memory CD8 ؉ CD62L hi T cell precursors thus segregate from the outset into populations expressing ''best-fit'' and ''suboptimal'' TCR characteristics, with this pattern being maintained stably thereafter. Hence, our analysis suggests that early establishment of influenza-specific memory within the CD8 ؉ CD62L hi subset preserves clonal diversity and prevents ''overdominance'' by a few public, or shared, clones.influenza A virus ͉ T cell receptor repertoire

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“…T CM are an earlier stage of differentiation and therefore possess superior qualities enabling them to better fight microbial challenges and mediate therapeutic antitumor immunity when compared to T EM , which in turn are superior to the terminally differentiated effector cells (4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Enhanced Therapeutic Efficacy and Memory of Tumor-Specific CD8 T Cells by Ex Vivo PI3K-δ Inhibition

et al. 2017

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Inhibition of specific Akt isoforms in CD8+ T cells promotes favored differentiation into memory versus effector cells, the former of which are superior in mediating anti-tumor immunity. In this study, we investigated the role of upstream PI3K isoforms in CD8+ T cell differentiation and assessed the potential use of PI3K isoform-specific inhibitors to favorably condition CD8+ T cells for adoptive cell therapy. The phenotype and proliferative ability of tumor antigen specific CD8+ T cells was assessed in the presence of PI3K-α, -β, or -δ inhibitors.Inhibition of PI3K-δ, but not PI3K-α or PI3K-β, delayed terminal differentiation of CD8+ T cells and maintained the memory phenotype, thus enhancing their proliferative ability and survival while maintaining their cytokine and granzyme B production ability. This effect was preserved in vivo after of ex vivo PI3K-δ inhibition in CD8+ T cells destined for adoptive transfer, enhancing their survival and also the anti-tumor therapeutic activity of a tumor-specific peptide vaccine.Our results outline a mechanism by which inhibitions of a single PI3K isoform can enhance the proliferative potential, function and survival of CD8+ T cells, with potential clinical implications for adoptive cell transfer and vaccine-based immunotherapies.

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Differential contributions of central and effector memory T cells to recall responses

Cited by 252 publications

References 48 publications

Hollow microneedle-mediated intradermal delivery of model vaccine antigen-loaded PLGA nanoparticles elicits protective T cell-mediated immunity to an intracellular bacterium

Hollow microneedle-mediated intradermal delivery of model vaccine antigen-loaded PLGA nanoparticles elicits protective T cell-mediated immunity to an intracellular bacterium

Early establishment of diverse T cell receptor profiles for influenza-specific CD8⁺CD62L^himemory T cells

Enhanced Therapeutic Efficacy and Memory of Tumor-Specific CD8 T Cells by Ex Vivo PI3K-δ Inhibition

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Differential contributions of central and effector memory T cells to recall responses

Cited by 252 publications

References 48 publications

Hollow microneedle-mediated intradermal delivery of model vaccine antigen-loaded PLGA nanoparticles elicits protective T cell-mediated immunity to an intracellular bacterium

Hollow microneedle-mediated intradermal delivery of model vaccine antigen-loaded PLGA nanoparticles elicits protective T cell-mediated immunity to an intracellular bacterium

Early establishment of diverse T cell receptor profiles for influenza-specific CD8+CD62Lhimemory T cells

Enhanced Therapeutic Efficacy and Memory of Tumor-Specific CD8 T Cells by Ex Vivo PI3K-δ Inhibition

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Early establishment of diverse T cell receptor profiles for influenza-specific CD8⁺CD62L^himemory T cells