Differential Control by 5‐<scp>HT</scp> and 5‐<scp>HT</scp>1A, 2A, 2C Receptors of Phasic and Tonic <scp>GABAA</scp> Inhibition in the Visual Thalamus

Crunelli, Vincenzo; Giovanni, Giuseppe Di

doi:10.1111/cns.12480

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-Ht Excites Pvt Neurons Through Direct Depolarization and Indirect Disinhibition1

Different Models Of Audiogenic Epilepsy In Rodents1

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2024

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Cited by 8 publications

(2 citation statements)

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“…Previous studies reported that 5-HT decreased tonic GABA currents in both visual cortex and visual thalamus (Crunelli & Di Giovanni, 2015). However, no tonic GABA current was recorded when the membrane potential (−70 mV) is close to the reversal potential of Clchannels using potassium gluconate (2 mM Cl -) pipette solution for the recording (Fig.…”

Section: -Ht Excites Pvt Neurons Through Direct Depolarization and Indirect Disinhibitionmentioning

confidence: 91%

Serotonin activates paraventricular thalamic neurons through direct depolarization and indirect disinhibition from zona incerta

Zhang

2021

The Journal of Physiology

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Section: -Ht Excites Pvt Neurons Through Direct Depolarization and Indirect Disinhibitionmentioning

confidence: 91%

Serotonin activates paraventricular thalamic neurons through direct depolarization and indirect disinhibition from zona incerta

Zhang

2021

The Journal of Physiology

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“…Audiogenic seizures in this strain started to develop at 60–75 days of age, and by day 120, 100% of animals tested were AE-prone. Data on the role of the serotoninergic system in epilepsy development are inconsistent and depend on the epilepsy form (in humans) or animal model [ 189 , 190 , 191 , 192 , 193 ].…”

Section: Different Models Of Audiogenic Epilepsy In Rodentsmentioning

confidence: 99%

Rodent Models of Audiogenic Epilepsy: Genetic Aspects, Advantages, Current Problems and Perspectives

et al. 2022

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Animal models of epilepsy are of great importance in epileptology. They are used to study the mechanisms of epileptogenesis, and search for new genes and regulatory pathways involved in the development of epilepsy as well as screening new antiepileptic drugs. Today, many methods of modeling epilepsy in animals are used, including electroconvulsive, pharmacological in intact animals, and genetic, with the predisposition for spontaneous or refractory epileptic seizures. Due to the simplicity of manipulation and universality, genetic models of audiogenic epilepsy in rodents stand out among this diversity. We tried to combine data on the genetics of audiogenic epilepsy in rodents, the relevance of various models of audiogenic epilepsy to certain epileptic syndromes in humans, and the advantages of using of rodent strains predisposed to audiogenic epilepsy in current epileptology.

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5-HT/GABA interaction in epilepsy

Deidda

Crunelli

Giovanni

2021

Progress in Brain Research

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Differential Control by 5‐HT and 5‐HT1A, 2A, 2C Receptors of Phasic and Tonic GABAA Inhibition in the Visual Thalamus

Cited by 8 publications

References 13 publications

Serotonin activates paraventricular thalamic neurons through direct depolarization and indirect disinhibition from zona incerta

Serotonin activates paraventricular thalamic neurons through direct depolarization and indirect disinhibition from zona incerta

Rodent Models of Audiogenic Epilepsy: Genetic Aspects, Advantages, Current Problems and Perspectives

5-HT/GABA interaction in epilepsy

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