Differential correlations between inflammatory cytokines and psychopathology in veterans with schizophrenia: Potential role for IL-17 pathway

Dimitrov, D; Lee, Shuko; Yantis, Jesse; Valdez, C. R.; Paredes, Roger; Braida, Nicole; Velligan, Dawn I.; Walss‐Bass, Consuelo

doi:10.1016/j.schres.2013.10.019

Cited by 102 publications

(63 citation statements)

References 37 publications

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“…Dalje, jedna od frekventno eksplorisanih teorija je "T helper hipoteza" govori o disblansu izmedju T helper-tip 1(Th1)/tip 2 (Th2) imunog odgovora, u korist "prevage" Th-2 odgovora kod obolelih od shizofrenije i posledičnih disregulacija u kinureninskom putu i glutamatergičko-dopaminergičkim promenama [11,12]. Saznanje o dva nova subtipa T ćelija -Th17 i T regulatornih ćelija (Tregs), su značajni faktori u rasvetljavanju etiologije ovog oboljenja kao i kontrolnih mehanizama, pogotovo imajući u vidu da povećana produkcija Th-17 intenzivira inflamatornu reakciju i doprinosi oštećenju tkiva [13,14]. Jedna od interesantnih teorija je i " mikroglijalna hipoteza shizofrenije" prema kojoj aktivirana mikroglija oslobadja proinflamatorne citokine i slobodne radikale dovodeći do poremećene neurogeneze, neuralne degradacije, promena u beloj masi, a koje imaju krucijalnu ulogu u patogenezi shizofrenije [15,16].…”

Section: Kratak Sadržajunclassified

Schizophrenia and cytokines

Dunjić-Kostić¹,

Pantović-Stefanović²,

Ivković³

et al. 2015

Engrami

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Razvoj sofisticiranih tehnika detekcije strukturnih i biohemijskih abnormlnosti, u poslednjih nekoliko decenija, odigrao je važnu ulogu u preciznijem sagledavanju brojnih bioloških alteracija kod pacijenata uopšte. Ova činjenica je od posebne važnosti istraživačima u oblasti neuronauka, zbog često nepoznate i/ili multifaktorijalne etiopatogeneze neuropsihijatrijskih poremećaja, te svaki deo spoznaje kompleksnog "algoritma" ima svoje značajno mesto. U poslednje vreme veliku pažnju istraživača privlače eksploracija imunoloških abnormalnosti kod obolelih od shizofrenije, kao i citokinima posredovani mehanizmi koji predstavljaju osnovu za niz hipoteza iznesenih na ovu temu [1][2][3]. U daljem tekstu fokusiraće-mo se na nekoliko najvažnijih teorijskih pravaca koje se tiču inflamacije i imunoloških promena zapaženih u shizofreniji. Jedna od teorija je da je infekcija majke tokom trudnoće (naročito tokom ranog perinatalnog perioda) značajan faktor rizika za dete za razvoj shizofrenije i drugih neurorazvojnih oboljenja [4,5]. Epidemiološke studije su pokazale da infekcija majke virusom influence tokom trudnoće povećava rizik za shizofreniju deteta za 3-7 puta [4,6]. Pored virusa influence i brojni drugi infektivni činioci su povezani sa povećanim rizikom za SCH medju kojima su i varicela zoster virus, polio, difterija, rubela itd [5]. Medjutim, patološki mehanizam odgovoran za povećan rizik za shizofreniju kod dece nakon izloženosti majke infekciji još uvek je nedovoljno jasan. Takodje otvoreno je pitanje, na koji način infekcija majke dovodi do citokinskog disbalansa kod fetusa; da li je u pitnju delovanje infektivnog činioca na specifične receptore koji dovode do produkcije i oslobadjanja različitih medijatora zapaljenja u periferni majčin imuni sistem koji onda prolaze placentu i ulaze u cirkulaciju fetusa [6,7], ili potencijalni iz- Kratak sadržajPoslednjih par decenija pažnju istraživača sve više privlače imunološke abnormalnosti uočene kod obolelih od shizofrenije. U prvom delu teksta prikazan je kratak pregled pojedinih teorijskih konstrukata predloženih u cilju boljeg uvida u povezanost shizofrenije i imunoloških alteracija, u drugom delu je razmotren uticaj citokina na pojedine neurotransmiterske sisteme i finalno izneta su zapažanja dobijena iz istraživanja u realnoj kliničkoj situaciji kao i pravci budućih istraživanja.

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Section: Kratak Sadržajunclassified

Schizophrenia and cytokines

Dunjić-Kostić¹,

Pantović-Stefanović²,

Ivković³

et al. 2015

Engrami

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“…Several data support the inflammatory hypothesis in SCZ's pathophysiology. It is characterised by enhanced innate immune response with overproduction and/or imbalance of cytokines, namely an increase in pro-inflammatory and a decrease in anti-inflammatory cytokines [14,[18][19][20]. Cytokines, key signaling molecules of the immune system, exert their effects by binding specific receptors on a variety of peripheral and brain target cells [21].…”

Section: Immunoinflammatory Biomarkersmentioning

confidence: 99%

“…Cytokines, key signaling molecules of the immune system, exert their effects by binding specific receptors on a variety of peripheral and brain target cells [21]. Immune changes in the CNS may originate from peripheral immune activation of cytokines that cross the disrupted blood brain barrier (BBB) or that are synthesised by invading immune cells, both of which originate from extraneuronal sources and disturb brain function [18,22,23]. Nevertheless, most neuropathologies are most probably due to dysfunction of resident microglia and astrocytes [24].…”

Section: Immunoinflammatory Biomarkersmentioning

confidence: 99%

“…The IL-17 signalling pathway was also found to be dysregulated when compared to healthy controls and correlated with symptoms in veterans with SCZ [18]. IL-17 induces the production of factors implicated in the recruitment of monocytes and neutrophils [29].…”

Section: Immunoinflammatory Biomarkersmentioning

confidence: 99%

“…IL-17 induces the production of factors implicated in the recruitment of monocytes and neutrophils [29]. The levels of very few of those factors were found to be positively or negatively correlated with positive, general and total scores on the Positive and Negative Syndrome Scale (PANSS) in most studies conducted so far [18,21,31]. Moreover, a previous study found increased activation of T-helper-17 cells in patients with recent onset SCZ [30].…”

Section: Immunoinflammatory Biomarkersmentioning

confidence: 99%

See 2 more Smart Citations

Biomarkers and schizophrenia: a qualitative review

Silva¹,

Pinto²

2017

IJCNMH

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Schizophrenia (SCZ) is a psychiatric disorder with a broad spectrum of biological and clinical manifestations of yet not completely clear pathophysiological mechanisms. Several lines of evidence have been supporting the idea that immunoinflammatory, oxidative, hormonal and cellular dysfunctions are implicated on the biomolecular basis of SCZ. However, accurate diagnosis and selection of appropriate treatments remains challenging as a result of the scarcity of objective tests. Furthermore, there is a compelling need to find biomarkers that could predict drug response and tailor pharmacological treatment, particularly in drug-naïve first episode psychosis (FEP). Hence, numerous technologies have been employed in order to search for SCZ biological markers, but evidence relating them to treatment efficacy is lacking. In this regard, some preliminary data suggest promising results. The current review provides information on: (1) potential biomarkers associated with biological disturbances and (2) biological markers associated with treatment response.

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Neurodevelopmental Theories of Schizophrenia: Twenty‐First Century Perspectives

Haut

Schvarcz

Cannon

et al. 2016

Developmental Psychopathology

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Schizophrenia is a devastating mental illness afflicting about 1 percent of the population, involving delusions and hallucinations. Although originally believed to be a disorder of neurodegeneration, multiple lines of inquiry now provide compelling evidence for its neurodevelopmental origins. As such, one of the most puzzling aspects about this disorder is its characteristic onset in late adolescence or early adulthood. In this chapter we review evidence for the involvement of both early (genetic and perinatal) and later (adolescent) neurodevelopmental influences in the etiology and pathogenesis of schizophrenia. New findings regarding its genetic architecture implicate both common and rare genetic variants that converge on pathways involving disruption of synaptic plasticity, which may be related to neural endophenotypes present in both patients and their clinically unaffected relatives. Together, these findings suggest a combination of these early and later neurodevelopmental factors converge to produce the cellular, structural, and functional deficits underlying the disorder.

show abstract

Differential correlations between inflammatory cytokines and psychopathology in veterans with schizophrenia: Potential role for IL-17 pathway

Cited by 102 publications

References 37 publications

Schizophrenia and cytokines

Schizophrenia and cytokines

Biomarkers and schizophrenia: a qualitative review

Neurodevelopmental Theories of Schizophrenia: Twenty‐First Century Perspectives

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