Differential cross section measurements for hadron therapy: 50 MeV/nucleon 
<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mmultiscripts><mml:mi mathvariant="normal">C</mml:mi><mml:mprescripts /><mml:none /><mml:mn>12</mml:mn></mml:mmultiscripts></mml:math>
 reactions on H, C, O, Al, and 
<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mmultiscripts><mml:mi>Ti</mml:mi><mml:mprescripts /><mml:none /><mml:mi>nat</mml:mi></mml:mmultiscripts></mml:math>
 targets

Divay, C.; Colin, J.; Cussol, D.; Finck, C.; Karakaya, Y.; Labalme, M.; Rousseau, M.; Salvador, S.; Vanstalle, M.

doi:10.1103/physrevc.95.044602

Cited by 12 publications

(12 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This involves a limited region of the available phase space and it is not trivial for available calculation models to reproduce with the same quality both fragmentation at small angles (the most important as far as dose is concerned) and the emission at large angles. As discussed later, there is a lack of experimental data useful for model tuning and benchmarking, and available data are limited in angle and primary energy [77,78]. Double differential cross sections are eagerly needed.…”

Section: Calculation Of Secondary Products For Range Monitoring Purposesmentioning

confidence: 99%

Challenges in Monte Carlo Simulations as Clinical and Research Tool in Particle Therapy: A Review

2020

View full text Add to dashboard Cite

The use and interest in Monte Carlo (MC) techniques in the field of medical physics have been rapidly increasing in the past years. This is the case especially in particle therapy, where accurate simulations of different physics processes in complex patient geometries are crucial for a successful patient treatment and for many related research and development activities. Thanks to the detailed implementation of physics processes in any type of material, to the capability of tracking particles in 3D, and to the possibility of including the most important radiobiological effects, MC simulations have become an essential calculation tool not only for dose calculations but also for many other purposes, like the design and commissioning of novel clinical facilities, shielding and radiation protection, the commissioning of treatment planning systems, and prediction and interpretation of data for range monitoring strategies. MC simulations are starting to be more frequently used in clinical practice, especially in the form of specialized codes oriented to dose calculations that can be performed in short time. The use of general purpose MC codes is instead more devoted to research. Despite the increased use of MC simulations for patient treatments, the existing literature suggests that there are still a number of challenges to be faced in order to increase the accuracy of MC calculations for patient treatments. The goal of this review is to discuss some of these remaining challenges. Undoubtedly, it is a work for which a multidisciplinary approach is required. Here, we try to identify some of the aspects where the community involved in applied nuclear physics, radiation biophysics, and computing development can contribute to find solutions. We have selected four specific challenges: i) the development of models in MC to describe nuclear physics interactions, ii) modeling of radiobiological processes in MC simulations, iii) developments of MC-based treatment planning tools, and iv) developments of fast MC codes. For each of them, we describe the underlying problems, present selected examples of proposed solutions, and try to give recommendations for future research.

show abstract

Section: Calculation Of Secondary Products For Range Monitoring Purposesmentioning

confidence: 99%

Challenges in Monte Carlo Simulations as Clinical and Research Tool in Particle Therapy: A Review

2020

View full text Add to dashboard Cite

show abstract

“…In practice, this is typically not feasible. However, there are examples of systematic measurements of double differential fragmentation cross sections of light projectiles on different thin targets, for example, with 50 MeV/n (3 + -39 + ) and 95 MeV/n (4 + -39 + ) 12 C beams [39][40][41] performed at GANIL. As usual, this experimental setup does not cover the entire spectrum of fragment information (mass, charge, energy, and angle).…”

Section: Importance Of Double Differential Cross Sectionsmentioning

confidence: 99%

Are Further Cross Section Measurements Necessary for Space Radiation Protection or Ion Therapy Applications? Helium Projectiles

et al. 2020

View full text Add to dashboard Cite

The helium (4He) component of the primary particles in the galactic cosmic ray spectrum makes significant contributions to the total astronaut radiation exposure. 4He ions are also desirable for direct applications in ion therapy. They contribute smaller projectile fragmentation than carbon (12C) ions and smaller lateral beam spreading than protons. Space radiation protection and ion therapy applications need reliable nuclear reaction models and transport codes for energetic particles in matter. Neutrons and light ions (1H, 2H, 3H, 3He, and 4He) are the most important secondary particles produced in space radiation and ion therapy nuclear reactions; these particles penetrate deeply and make large contributions to dose equivalent. Since neutrons and light ions may scatter at large angles, double differential cross sections are required by transport codes that propagate radiation fields through radiation shielding and human tissue. This work will review the importance of 4He projectiles to space radiation and ion therapy, and outline the present status of neutron and light ion production cross section measurements and modeling, with recommendations for future needs.

show abstract

“…The setup was located in a vacuum reaction chamber. A detailed description of the experiment setup can be found in [5].…”

Section: The 50 Mev/nucleon Experimentsmentioning

confidence: 99%

“…Some misidentification and pile-up events in the detectors have been removed thanks to the use of a Pulse Shape Analysis of the CsI signal. The method describing in details the different analysis processes can be found in [5,9]. The angular cross-sections were calculated using the formula:…”

Section: The 50 Mev/nucleon Experimentsmentioning

confidence: 99%

See 1 more Smart Citation

Differential cross-sections measurements for hadrontherapy: 50 MeV/A¹²C reactions on H, C, O, Al and^natTi targets

et al. 2017

Self Cite

View full text Add to dashboard Cite

Abstract. In order to keep the benefits of a carbon treatment, the dose and biological effects induced by secondary fragments must be taken into account when simulating the treatment plan. These Monte-Carlo simulations codes are done using nuclear models that are constrained by experimental data. It is hence necessary to have precise measurements of the production rates of these fragments all along the beam path and for its whole energy range. In this context, a series of experiments aiming to measure the double differential fragmentation cross-sections of carbon on thin targets of medical interest has been started by our collaboration. In March 2015, an experiment was performed with a 50 MeV/nucleon 12 C beam at GANIL. During this experiment, energy and angular differential cross-section distributions on H, C, O, Al and nat Ti have been measured. In the following, the experimental set-up and analysis process are briefly described and some experimental results are presented. Comparisons between several exit channel models from PHITS and GEANT4 show great discrepancies with the experimental data. Finally, the homemade SLIIPIE model is briefly presented and preliminary results are compared to the data with a promising outcome.

show abstract

Differential cross section measurements for hadron therapy: 50 MeV/nucleon C12 reactions on H, C, O, Al, and Tinat targets

Cited by 12 publications

References 22 publications

Challenges in Monte Carlo Simulations as Clinical and Research Tool in Particle Therapy: A Review

Challenges in Monte Carlo Simulations as Clinical and Research Tool in Particle Therapy: A Review

Are Further Cross Section Measurements Necessary for Space Radiation Protection or Ion Therapy Applications? Helium Projectiles

Differential cross-sections measurements for hadrontherapy: 50 MeV/A¹²C reactions on H, C, O, Al and^natTi targets

Contact Info

Product

Resources

About

Differential cross section measurements for hadron therapy: 50 MeV/nucleon C12 reactions on H, C, O, Al, and Tinat targets

Cited by 12 publications

References 22 publications

Challenges in Monte Carlo Simulations as Clinical and Research Tool in Particle Therapy: A Review

Challenges in Monte Carlo Simulations as Clinical and Research Tool in Particle Therapy: A Review

Are Further Cross Section Measurements Necessary for Space Radiation Protection or Ion Therapy Applications? Helium Projectiles

Differential cross-sections measurements for hadrontherapy: 50 MeV/A12C reactions on H, C, O, Al andnatTi targets

Contact Info

Product

Resources

About

Differential cross-sections measurements for hadrontherapy: 50 MeV/A¹²C reactions on H, C, O, Al and^natTi targets