Differential Cytotoxicity and Gene Expression in Human Liver Carcinoma (HepG2) Cells Exposed to Arsenic Trioxide, and Monosodium Acid Methanearsonate (MSMA)

Tchounwou, Paul B.; Wilson, Barbara A.; Abdelghani, A. A.; Ishaque, Ali; Patlolla, Anita K.

doi:10.3390/i3111117

Cited by 35 publications

(17 citation statements)

References 36 publications

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“…Arsenic also insecticides, herbicides, fungicides, such as agricultural applications, rat poison, some cancer drugs, paints, wallpaper is used as wood preservatives with various items of manufacture and sheep wool, ceramic. 5 The exposure of arsenic in human is associated with cancers, organ damage and immunotoxicity. 6 Arsenic toxicity generates reactive oxygen species (ROS) such as hydroxyl radicals ( Á OH), superoxide anion (O À 2 ) through chain reactions and causes severity oxidative damage of the cells.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney

et al. 2015

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We aimed to investigate the protective role of thymoquinone (TQ) by targeting its antiapoptotic and antioxidant properties against kidney damage induced by arsenic in rats. We have used the 24 male Sprague-Dawley rats. Rats were divided into three groups. Physiological serum in 10 mL/kg dose as intragastric was given to the control group. Sodium arsenite (10 mg/kg, intragastric by gavage for fifteen days) was given to the arsenic group. Sodium arsenite (10 mg/kg, intragastric by gavage for fifteen days) and TQ (10 mg/kg, intragastric by gavage for 15 days) was given to the arsenic + TQ group. After 15 days, the animals' kidneys were taken theirs, then we have performed histological and apoptotic assessment. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) enzyme activities and malondialdehyde (MDA) levels have examined as the oxidative stress parameters. We have determined the levels of arsenic. Increased renal injury and apoptotic cells have been detected in the arsenic group. Degenerative changes in the arsenic + TQ group were diminished. Although the MDA levels were augmented in the arsenic group, SOD, CAT and GSH-Px enzyme activities were lessened than the other groups. Our findings suggest that TQ may impede the oxidative stress, the cells have been damaged and also the generation of apoptotic cells arisen from arsenic. TQ plays a protective role against arsenic-induced toxicity in kidney and may potentially be used as a remedial agent.

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Section: Introductionmentioning

confidence: 99%

Protective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney

et al. 2015

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“…People who produce or use arsenic compounds in occupations such as nonferrous metal smelting, pesticide manufacturing and application, wood preservation, semiconductor manufacturing, or glass production can be exposed by substantially higher levels of arsenic [8,10,18,19]. As stated earlier, different species of arsenic have different degrees of toxicity, with arsine and the trivalent arsenic causing the most injury [22]. In addition to the exposure route and the arsenic species involved, the toxicity also depends on the exposure dose, frequency, duration, the biological species, age, and gender, as well as on individual susceptibilities, genetic and nutritional factors [8,16,19].…”

Section: Exposure Assessmentmentioning

confidence: 99%

“…A review of biological properties and toxic effects of arsenic indicates that this chemical is a systemic toxicant capable of causing a significant number of health effects including: cardiovascular disease, peripheral vascular disease, developmental effects, neurologic and neurobehavioral effects, diabetes, hearing loss, portal fibrosis of the liver, lung fibrosis, hematologic effects (anemia, leukopenia, and eosinophilia), and carcinogenic effects [2,7,8,16,19,22]. Studies in Taiwan have reported that in areas where blackfoot disease is endemic, the standardized and cumulative mortality rates were significantly higher for cancer of the bladder, kidney, skin, liver, lung and colon.…”

Section: Risk Characterizationmentioning

confidence: 99%

Arsenic toxicity and carcinogenesis: a public health risk assessment and management approach

Tchounwou¹

2008

WIT Transactions on Ecology and the Environment

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Acute and chronic exposure to arsenic has been reported in several countries of the world, with major outbreaks of arsenosis occurring in Argentina, Bangladesh, India, Mexico, Thailand, and Taiwan, where a large proportion of drinking water (groundwater) is contaminated with high concentrations of arsenic. Research has also pointed to significantly higher standardized mortality rates for cancers of the bladder, kidney, skin, liver, and colon in many areas of arsenic pollution. There is therefore a great need for developing a comprehensive risk assessment model that should be used in the effective management of health risks associated with arsenic exposure. With a special emphasis on arsenic toxicity and carcinogenesis, this paper aims at developing and presenting a conceptual risk assessment and management model. Using the National Academy of Science's risk assessment and management framework as a guide, all critical information has been analyzed and presented with respect to the health hazard, the sources and pathways of human exposure, the concept of the dose-response relationship in arsenic poisoning, the characterization of both systemic and carcinogenic effects, and the potential strategies to control and/or prevent arsenic poisoning.

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“…Different species of arsenic have different levels of toxicity [21,22]. For example, arsenobetaine, which is the major converted form of arsenic found in various marine animals, has been shown to be relatively non-toxic [21].…”

Section: Human Health Risk Assessmentmentioning

confidence: 99%

Effects of Long-Term Exposure of the Red Swamp Crawfish Procambarus clarkii to a Mixture of Two Herbicides, 2,4-Dichloro-phenoxyacetic Acid and Monosodium Methanearsonate, and Associated Human Health Risks

Green

Abdelghani

2004

IJERPH

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2,4-dichlorophenoxyacetic acid and monosodium methanearsonate are often sold in commercial mixtures. Bioconcentration studies have been performed for each of these herbicides individually, but little information exists concerning long-term exposure to a mixture of these herbicides. The following study examined the uptake of arsenic in crawfish after long-term exposure to this mixture, and the health risks associated with consumption of these crawfish. Bioconcentration and depuration experiments using a 50:50 by concentration mixture of the two herbicides, with and without surfactant, were performed to quantify how much arsenic is concentrated in the edible tissue of the crawfish. Of the three tissues (muscle, gill, and hepatopancreas) sampled hepatopancreas bioconcentrated the highest amount of arsenic. Surfactant significantly reduced this uptake but did not affect bioconcentration of arsenic into other tissues. Surfactant had no effect on depuration of arsenic from any of the tissues. Cooking lowered hepatopancreatic arsenic content, possibly as a result of structural changes in the hepatopancreas. Assessment of the human health risk associated with consuming these crawfish showed an exposure dose at the high end of consumption that was approximately twice the reference dose for arsenic. Cancer risks were averaged at approximately 7 extra tumors in a population of 10,000 and 6 extra tumors in a population of 10,000 resulting from a lifetime consumption of crawfish exposed to the herbicide mixture without and with surfactant, respectively.

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Differential Cytotoxicity and Gene Expression in Human Liver Carcinoma (HepG2) Cells Exposed to Arsenic Trioxide, and Monosodium Acid Methanearsonate (MSMA)

Cited by 35 publications

References 36 publications

Protective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney

Protective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney

Arsenic toxicity and carcinogenesis: a public health risk assessment and management approach

Effects of Long-Term Exposure of the Red Swamp Crawfish Procambarus clarkii to a Mixture of Two Herbicides, 2,4-Dichloro-phenoxyacetic Acid and Monosodium Methanearsonate, and Associated Human Health Risks

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