Differential cytotoxicity of ferromagnetic Co doped CeO2 nanoparticles against human neuroblastoma cancer cells

Abbas, Fazal; Iqbal, Javed; Jan, T.; Naqvi, M. Sajjad H.; Gul, Asma; Abbasi, Rashda; Mahmood, Asif; Ahmad, Ishaq; Ismail, Muhammad

doi:10.1016/j.jallcom.2015.06.195

Cited by 50 publications

(36 citation statements)

References 47 publications

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“…27 The spectra due to stretching frequency of Ce-O can be seen at 459 cm Figure 8 illustrates the UV-visible absorption spectra of CeO 2 NPs, which demonstrates the presence of a single intensified peak at 315 nm that was also closely observed in previous studies. 25 The position of the absorption peak confirms that green synthesized CeO 2 NPs possess fluorite cubic morphology, 26 as justified in Figures 4 and 5.…”

Section: Ftir Spectroscopy Analysissupporting

confidence: 67%

“…32 CeO 2 NPs fabricated by way of chemical methods were also found to be cytotoxic to somatic cells. 25 O. europaea leaf extract also takes part in inhibiting K. pneumoniae, S. aureus, and P. aeruginosa, with ZOI of 8, 7.6, and 7.8 mm, respectively; its potential activity has also been reported in previous studies. 33,34 Bioactive compounds from the leaf extract, such as oleuropein, are also found to be magically active in inhibiting several bacterial pathogens.…”

supporting

confidence: 66%

“…The observed value was found to be close to that reported previously. 25 The calculated value of lattice constant "a" is 0.585 nm, while the unit cell volume "V" is measured to be 0.20 nm.…”

mentioning

confidence: 97%

“…It is a well-known fact that Ce, as compared to its bulk, forms low band gap energy which results in its photoexcitation at room temperature. 25 This phenomenon will also assist in mass production of ROS inside bacterial cellular environment, and intoleration of ROS due to CeO 2 NPs results in malfunctioning of microbial biosynthetic machinery, causing lethality. In Figure 11 is presented a possible schematic diagram summarizing the above fact.…”

mentioning

confidence: 99%

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Antimicrobial potential of green synthesized CeO2 nanoparticles from Olea europaea leaf extract

Maqbool

Nazar

Naz

et al. 2016

IJN

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156

101

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This article reports the green fabrication of cerium oxide nanoparticles (CeO 2 NPs) using Olea europaea leaf extract and their applications as effective antimicrobial agents. O. europaea leaf extract functions as a chelating agent for reduction of cerium nitrate. The resulting CeO 2 NPs exhibit pure single-face cubic structure, which is examined by X-ray diffraction, with a uniform spherical shape and a mean size 24 nm observed through scanning electron microscopy and transmission electron microscopy. Ultraviolet-visible spectroscopy confirms the characteristic absorption peak of CeO 2 NPs at 315 nm. Fourier transform infrared spectroscopy reflects stretching frequencies at 459 cm −1 , showing utilization of natural components for the production of NPs. Thermal gravimetric analysis predicts the successful capping of CeO 2 NPs by bioactive molecules present in the plant extract. The antimicrobial studies show significant zone of inhibition against bacterial and fungal strains. The higher activities shown by the green synthesized NPs than the plant extract lead to the conclusion that they can be effectively used in biomedical application. Furthermore, reduction of cerium salt by plant extract will reduce environmental impact over chemical synthesis.

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Section: Ftir Spectroscopy Analysissupporting

confidence: 67%

supporting

confidence: 66%

mentioning

confidence: 97%

mentioning

confidence: 99%

See 2 more Smart Citations

Antimicrobial potential of green synthesized CeO2 nanoparticles from Olea europaea leaf extract

Maqbool

Nazar

Naz

et al. 2016

IJN

Self Cite

156

101

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“…Reactive oxygen species (ROS) detection was carried out by flow cytometry. [32,33] III. RESULTS AND DISCUSSIONS XRD patterns of the prepared samples in the 2h range of (20-80) are depicted in Figure 1.…”

Section: B Cell Culture and Treatmentmentioning

confidence: 99%

Mg Doping Induced Effects on Structural, Optical, and Electrical Properties as Well as Cytotoxicity of CeO2 Nanostructures

Iqbal

Jan

Awan³

et al. 2016

Metall Mater Trans B

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Here, Mg x Ce 1Àx O 2 (where x = 0, 0.01, 0.02, 0.03, 0.04, and 0.05) nanostructures have been successfully synthesized by using a simple, easy, and cost-effective soft chemical method. X-ray diffraction (XRD) patterns substantiate the single-phase formation of a CeO 2 cubic fluorite structure for all samples. Infrared spectroscopy results depict the presence of peaks only related to Ce-O bonding, which confirms the XRD results. It has been observed via ultraviolet (UV)-visible spectroscopy that Mg doping has tuned the optical band gap of CeO 2 significantly. The electrical conductivity of CeO 2 nanostructures has been found to increase with Mg doping, which is attributed to enhancement in carrier concentration due to the different valance states of dopant and host ions. Selective cytotoxic behavior of Mg x Ce 1Àx O 2 nanostructures has been determined for neuroblastoma (SH-SY5Y) cancerous and HEK-293 healthy cells. Both doped and undoped CeO 2 nanostructures have been found to be toxic for cancer cells and safe toward healthy cells. This selective toxic behavior of the synthesized nanostructures has been assigned to the different levels of reactive oxygen species (ROS) generation in different types of cells. This makes the synthesized nanostructures a potential option for cancer therapy in the near future.

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Effect of defect states and oxygen vacancies on optical transitions due to Co2+ substitution in CeO2

et al. 2018

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Differential cytotoxicity of ferromagnetic Co doped CeO2 nanoparticles against human neuroblastoma cancer cells

Cited by 50 publications

References 47 publications

Antimicrobial potential of green synthesized CeO<sub>2</sub> nanoparticles from <em>Olea europaea</em> leaf extract

Antimicrobial potential of green synthesized CeO<sub>2</sub> nanoparticles from <em>Olea europaea</em> leaf extract

Mg Doping Induced Effects on Structural, Optical, and Electrical Properties as Well as Cytotoxicity of CeO2 Nanostructures

Effect of defect states and oxygen vacancies on optical transitions due to Co2+ substitution in CeO2

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