Differential detection of metastatic and inflammatory lymph nodes using inflow-based vascular-space-occupancy (iVASO) MR imaging

Guo, Liwei; Liu, Xiaomin; Hua, Jun; Dai, Letian; Ying, Tao; Cao, Haimei; Qin, Jie; Li, Xiaodan; Wu, Yuankui

doi:10.1016/j.mri.2021.10.035

Cited by 3 publications

(1 citation statement)

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“…When flow-sensitive crushing gradients are incorporated to remove fast-flowing blood signals in large arteries, CBVa measured in iVASO MRI can be sensitized predominantly to microvasculature with arterial blood, here defined as small pial arteries and arterioles. Because CBVa is an important indicator of tissue perfusion and the integrity of microvasculature, iVASO MRI has been applied in a number of clinical studies, 7 including stroke 6 ; brain tumors [8][9][10][11][12][13][14] ; mental disorders such as schizophrenia 15,16 ; and neurodegenerative diseases such as Huntington's disease, Alzheimer's disease, and Parkinson's disease, [17][18][19][20] as well as in other tissue such as muscle. 21 In iVASO MRI, CBVa is calculated from the difference signal between an arterial blood nulled image and a second image without blood nulling (control).…”

Section: Introductionmentioning

confidence: 99%

On the optimization of 3D inflow‐based vascular‐space‐occupancy (iVASO) MRI for the quantification of arterial cerebral blood volume (CBVa)

Gu,

Li,

Cao

et al. 2023

Magnetic Resonance in Med

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PurposeThe inflow‐based vascular‐space‐occupancy (iVASO) MRI was originally developed in a single‐slice mode to measure arterial cerebral blood volume (CBVa). When vascular crushers are applied in iVASO, the signals can be sensitized predominantly to small pial arteries and arterioles. The purpose of this study is to perform a systematic optimization and evaluation of a 3D iVASO sequence on both 3 T and 7 T for the quantification of CBVa values in the human brain.MethodsThree sets of experiments were performed in three separate cohorts. (1) 3D iVASO MRI protocols were compared to single‐slice iVASO, and the reproducibility of whole‐brain 3D iVASO MRI was evaluated. (2) The effects from different vascular crushers in iVASO were assessed. (3) 3D iVASO MRI results were evaluated in arterial and venous blood vessels identified using ultrasmall‐superparamagnetic‐iron‐oxides–enhanced MRI to validate its arterial origin.Results3D iVASO scans showed signal‐to‐noise ratio (SNR) and CBVa measures consistent with single‐slice iVASO with reasonable intrasubject reproducibility. Among the iVASO scans performed with different vascular crushers, the whole‐brain 3D iVASO scan with a motion‐sensitized‐driven‐equilibrium preparation with two binomial refocusing pulses and an effective TE of 50 ms showed the best suppression of macrovascular signals, with a relatively low specific absorption rate. When no vascular crusher was applied, the CBVa maps from 3D iVASO scans showed large CBVa values in arterial vessels but well‐suppressed signals in venous vessels.ConclusionA whole‐brain 3D iVASO MRI scan was optimized for CBVa measurement in the human brain. When only microvascular signals are desired, a motion‐sensitized‐driven‐equilibrium–based vascular crusher with binomial refocusing pulses can be applied in 3D iVASO.

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Section: Introductionmentioning

confidence: 99%

On the optimization of 3D inflow‐based vascular‐space‐occupancy (iVASO) MRI for the quantification of arterial cerebral blood volume (CBVa)

Gu,

Li,

Cao

et al. 2023

Magnetic Resonance in Med

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Carbonic anhydrase IX stratifies patient prognosis and identifies nodal status in animal models of nasopharyngeal carcinoma using a targeted imaging strategy

Huang

Wang

Huang

et al. 2022

Eur J Nucl Med Mol Imaging

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Cottontail Rabbit Papillomavirus (CRPV) Related Animal Models for Head and Neck Cancer Research: A Comprehensive Review of the Literature

Bette,

Mandic

2024

Viruses

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Having suitable animal models is crucial to mimic human disease states and for the successful transfer of experimental data into clinical practice. In the field of papillomavirus research, the domestic rabbit (Oryctolagus cuniculus) has served as an indispensable model organism for almost 100 years. The identification and characterization of the first papillomaviruses in rabbits, their carcinogenic potential and their immunogenicity have contributed significantly to the state of knowledge on the genetics and life cycle of papillomaviruses in general, as well as the development of antiviral strategies such as vaccination procedures. Due to the high species specificity of papillomaviruses, only rabbit papillomaviruses (RPVs) can be used for animal studies on papilloma-based tumor diseases in the rabbit. The major focus of this article is on cottontail rabbit papillomavirus (CRPV)-related rabbit squamous cell carcinoma (RSCC). A brief history outlines the discovery and generation of experimentally used RSCC tumors. A comprehensive overview of the current CRPV-associated VX2 carcinoma-based tumor models with a major focus on human head and neck squamous cell carcinoma (HNSCC) tumor models is provided, and their strengths in terms of transferability to human HNSCC are discussed.

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Differential detection of metastatic and inflammatory lymph nodes using inflow-based vascular-space-occupancy (iVASO) MR imaging

Cited by 3 publications

References 38 publications

On the optimization of 3D inflow‐based vascular‐space‐occupancy (iVASO) MRI for the quantification of arterial cerebral blood volume (CBVa)

On the optimization of 3D inflow‐based vascular‐space‐occupancy (iVASO) MRI for the quantification of arterial cerebral blood volume (CBVa)

Carbonic anhydrase IX stratifies patient prognosis and identifies nodal status in animal models of nasopharyngeal carcinoma using a targeted imaging strategy

Cottontail Rabbit Papillomavirus (CRPV) Related Animal Models for Head and Neck Cancer Research: A Comprehensive Review of the Literature

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