Differential developmental pattern of acid and alkaline phytase and phosphatase activities in rat intestine

Bhandari, S. D.

doi:10.1007/bf01949901

Cited by 8 publications

(1 citation statement)

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“…Since phytate-hydrolyzing activity has been demonstrated in the small intestines of rats and humans (1), most attention has been given to the endogenous enzyme. The highest hydrolyzing activity for sodium phytate has been found in the brush border of the duodenal mucosa (5) of rats, and this activity increases markedly in rats near the age of weaning and then remains relatively constant (14). The relative contributions of endogenous and bacterial phytate hydrolysis are significant because any decrease in phytate concentration in the small intestines would reduce its influence over the availability of metals absorbed there, whereas hydrolysis in the large intestines might only be important to coprophagous animals.…”

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confidence: 99%

Phytate hydrolysis by germfree and conventional rats

Wise¹,

Gilburt²

1982

Appl Environ Microbiol

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Phytic acid is a naturally occurring compound that reduces intestinal absorption of many metals. Early work suggests that some dietary phytate may be hydrolyzed in the large intestines by bacteria, but more recently nutritionists have suggested that a mucosal enzyme is responsible. This paper reports a study intended to resolve this controversy. The hydrolysis of dietary phytic acid was measured in germfree and conventional rats fed either of two diets that differed in their calcium content. Negligible phytate hydrolysis occurred in the germfree rats, whereas 22 and 56% of the phytic acid was hydrolyzed by conventional rats fed highand low-calcium diets, respectively. We concluded that bacteria were responsible for the hydrolysis of phytate in these diets and that any activity of endogenous enzyme was negligible.

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confidence: 99%