Differential diagnosis between benign and malignant gallbladder diseases with real-time contrast-enhanced ultrasound

Xie, Xiaohua; Xu, Hui‐Xiong; Lü, Ming-De; Kuang, Ming; Xu, Zuo-Feng; Liu, Guangjian; Wang, Zhu; Liang, Jin-Yu; Chen, Li-Da; Lin, Manxia

doi:10.1007/s00330-009-1538-8

Cited by 118 publications

(148 citation statements)

References 21 publications

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“…Gallbladder and bile duct: Conventional gray-scale US is the first-line imaging investigation for diagnosis of gallbladder diseases, but can result in difficulty in determining the nature of the gallbladder lesions in some cases, especially in differentiating chronic cholecystitis with thickened wall from gallbladder carcinoma with thickened wall or in differentiating motionless sludge from gallbladder cancer [23,24] . Xie et al [23] evaluated the usefulness of CEUS in diagnosing gallbladder diseases.…”

Section: Ceusmentioning

confidence: 99%

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Era of diagnostic and interventional ultrasound

Xu¹

2011

WJR

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It is an era of diagnostic and interventional ultrasound (US). Various new techniques such as three-dimensional US (3D US), interventional US, and contrastenhanced US (CEUS) have been introduced into clinical practice. Dr. Xu and his colleagues have taken advantage of these techniques and carried out a series of relevant studies. Their use of 3D US in the liver, gallbladder, liver tumor volumetry, guidance for ablation, and 3D CEUS has widened the application of 3D US in the clinic. They found that prognosis in patients with hepatocellular carcinoma (HCC) after thermal ablation with curative intent was determined by treatment response to ablation, pretreatment serum AFP, and liver function reserve. Tumor response to treatment was the most predictive factor for long-term survival. They compared the use of percutaneous microwave ablation and radiofrequency ablation for the treatment of HCC and found that both are effective methods in treating HCCs. The local tumor control, complications related to treatment, and long-term survival were equivalent for the two modalities. They first compared the enhancement patterns of HCC and intrahepatic cholangiocarcinoma (ICC) and proposed the diagnostic clues for ICC, liver angiomyolipoma (AML), gallbladder cancer, renal carcinoma, and renal AML, which have greatly enhanced the role of CEUS in the clinic. They also evaluated the diagnostic performance of CEUS in characterizing complex cystic focal liver lesions and the agreement between two investigators with different experience levels; and found that CEUS is especially useful for the young investigator. They assessed the effect of anti-angiogenic gene therapy for HCC treated by microbubble-enhanced US exposure and concluded that gene therapy mediated by US exposure enhanced by a microbubble contrast agent may become a new treatment option for HCC.

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Section: Ceusmentioning

confidence: 99%

“…Xie et al [23] evaluated the usefulness of CEUS in diagnosing gallbladder diseases. They found that characters such as hyperenhancement or isoenhancement in the early phase and then fading out to hypoenhancement, as well as destruction of the gallbladder wall intactness, are more frequent in malignancy.…”

Section: Ceusmentioning

confidence: 99%

Era of diagnostic and interventional ultrasound

Xu¹

2011

WJR

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“…W początko-wym okresie są niedostrzegane lub bagatelizowane [2,4,7,9]. Najczęściej podawane dolegliwości wiążą się ze współistniejącą w większości przypadków kamicą pęcherzyka.…”

Section: Introductionunclassified

“…Najczęściej podawane dolegliwości wiążą się ze współistniejącą w większości przypadków kamicą pęcherzyka. Ataki kolki wątrobowej są jednak rzadkie, zwykle są to dolegliwości o typie rozpierania, uczucia dyskomfortu w prawym górnym kwadrancie jamy brzusznej [2,6,9]. Mają one charakter przewlekły, niekiedy nie ustępują po środkach rozkurczowych.…”

Section: Introductionunclassified

“…Mają one charakter przewlekły, niekiedy nie ustępują po środkach rozkurczowych. Miejscowy rozwój guza może doprowadzić do nie drożności przewodu pęcherzykowego, co w konsekwencji powoduje wystąpienie objawów podobnych do opisywanych w przebiegu ostrego zapalenia pęcherzyka żółciowego [3][4][5][6]9]. Badaniem palpacyjnym zazwyczaj stwierdza się obecność guza w okolicy pod prawym łukiem żebrowym.…”

Section: Introductionunclassified

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Gallbladder cancer – determination of the therapeutic possibilities in the imaging evaluation of tumour progression

Ćwik¹,

Solecki²,

Krupski³

et al. 2011

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Contrast‐enhanced ultrasound examination of the gallbladder and bile ducts: A pictorial essay

Cokkinos

Antypa

Tsolaki

et al. 2017

J of Clinical Ultrasound

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The gallbladder and bile ducts are usually assessed initially with conventional gray-scale ultrasound (US). Contrast enhanced US (CEUS) is used when a diagnosis cannot be reached with conventional US. CEUS is easy to learn and perform. US contrast agents can be safely administered in patients with renal function impairment. In this pictorial essay the physics, examination technique and indications of CEUS for examining the gallbladder and bile ducts are reviewed. Gallbladder indications include elucidating normal variants, differentiating sludge from neoplastic lesions, benign and malignant pathology, infection, wall rupture and hemobilia. In the biliary tree CEUS is used for studying benign and malignant tumors, including metastases and cholangiocarcinoma, as well as intrabiliary injection. K E Y W O R D Sbile ducts, CEUS, contrast agents, gallbladder, ultrasound | I N TR ODU C TI ONThe gallbladder and bile ducts are usually adequately imaged with grayscale sonography (US) and often no additional imaging is required. In cases when further imaging is needed to elucidate US findings, contrast-enhanced ultrasound (CEUS) overcomes the limitations of color Doppler imaging and can be used immediately after grayscale US examination. | PHYSICS OF US CONTRAST AGENTSContrast agents are composed of microbubbles of gas contained in a shell of protein, lipid, or polymer. 1 They have no renal or cardiac toxicity and can be safely administered in patients with renal insufficiency. CEUS examination requires dedicated contrast agent-specific techniques. 5,6 One of these techniques is phase inversion, where 2 different US pulses in opposite phases are emitted by the scanner sequentially. This achieves optimal contrast resolution and minimal stationary tissue signal. 7 A split-screen setting of the machine's monitor (dual view mode) allows simultaneous display of contrast-enhanced and conventional gray-scale images. However, a common artifact results from strongly reflective structures (eg, the diaphragm, vessel walls, the abdominal wall, or gas-filled structures) appearing as contrast enhancement on the CEUS part of the screen. 8

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Differential diagnosis between benign and malignant gallbladder diseases with real-time contrast-enhanced ultrasound

Cited by 118 publications

References 21 publications

Era of diagnostic and interventional ultrasound

Era of diagnostic and interventional ultrasound

Gallbladder cancer – determination of the therapeutic possibilities in the imaging evaluation of tumour progression

Contrast‐enhanced ultrasound examination of the gallbladder and bile ducts: A pictorial essay

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