Differential Diagnosis of Dengue Fever: Beware of Measles!: Table 1

Pull, Lauren; Brichler, Ségolène; Bouchaud, Olivier; Siriez, Jean-Yves

doi:10.1111/j.1708-8305.2012.00628.x

Cited by 8 publications

(4 citation statements)

References 13 publications

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“…Both g:Profiler and TargetMine also detected the measles and influenza A pathways (hsa05162 and hsa05164, respectively). Measles and influenza are often listed as diseases that differ negligibly from DF in terms of their diagnosis4445. There are no DENV pathways in the Kyoto Encyclopedia of Genes and Genomes (KEGG) database.…”

Section: Discussionmentioning

confidence: 99%

Principal Components Analysis Based Unsupervised Feature Extraction Applied to Gene Expression Analysis of Blood from Dengue Haemorrhagic Fever Patients

Taguchi

2017

Sci Rep

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Dengue haemorrhagic fever (DHF) sometimes occurs after recovery from the disease caused by Dengue virus (DENV), and is often fatal. However, the mechanism of DHF has not been determined, possibly because no suitable methodologies are available to analyse this disease. Therefore, more innovative methods are required to analyse the gene expression profiles of DENV-infected patients. Principal components analysis (PCA)-based unsupervised feature extraction (FE) was applied to the gene expression profiles of DENV-infected patients, and an integrated analysis of two independent data sets identified 46 genes as critical for DHF progression. PCA using only these 46 genes rendered the two data sets highly consistent. The application of PCA to the 46 genes of an independent third data set successfully predicted the progression of DHF. A fourth in vitro data set confirmed the identification of the 46 genes. These 46 genes included interferon- and heme-biosynthesis-related genes. The former are enriched in binding sites for STAT1, STAT2, and IRF1, which are associated with DHF-promoting antibody-dependent enhancement, whereas the latter are considered to be related to the dysfunction of spliceosomes, which may mediate haemorrhage. These results are outcomes that other type of bioinformatic analysis could hardly achieve.

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Section: Discussionmentioning

confidence: 99%

Principal Components Analysis Based Unsupervised Feature Extraction Applied to Gene Expression Analysis of Blood from Dengue Haemorrhagic Fever Patients

Taguchi

2017

Sci Rep

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“…Nonetheless, our results show that, even for samples collected within 7 days after onset of rash, 50% of the cases were negative for MeV RNA detection using real-time PCR. Since surveillance includes only the rubella infection as a differential diagnosis, which shows a very low incidence, the MoH in Morocco should consider other differential diagnoses, especially those spreading in our region, such as dengue fever[ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Real-Time PCR for Measles Virus Detection on Clinical Specimens with Negative IgM Result in Morocco

et al. 2016

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Since the confirmation of measles cases represents an important indicator regarding the performance of the measles-elimination program, the aim of this study was to evaluate the effectiveness of the routine procedures followed in Morocco for the laboratory confirmation of measles cases. Suspected cases reported between January 2010 and December 2012 were assessed for the timeliness of the sample collection, occurrence of measles clinical symptoms, and the results of the laboratory diagnoses. For 88% of the 2,708 suspected cases, a clinical specimen was collected within 7d of rash onset, of which 50% were IgM-positive and 2.6% were equivocal. The measles symptoms were reported in 91.4% of the cases; the occurrence of symptoms showed a positive association with the serological results (odds ratio [OR] = 2.9883, 95% confidence interval [CI] 2.2238–4.0157). Of the negative samples, 52% (n = 116) tested positive by real-time polymerase chain reaction (PCR). These results are in favor of using molecular detection to complement serological diagnosis in the context of measles surveillance approach in Morocco. In addition, the introduction of additional laboratory methods for differential diagnosis is required for the final classification of suspected cases with maculopapular rash and fever in the context of the measles elimination program.

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“…Hyperendemic transmission of all four dengue serotypes, with cases of DHF, was present in Thailand, Vietnam, and Indonesia for over 40 years. Epidemic dengue reemerged in China during the 1980s & the 1990s after absence of several decades; associated with the first DHF occurrence in that country (Qiu et al, 1993) Nepal, the last country in the region to be affected, had the first cases detected in 2004. Dengue virus transmission occurred yearround, but typically reaches a seasonal peak which varies in timing from one country to another (for example, between June & November in Thailand, but between January & February in Indonesia).…”

Section: Introductionmentioning

confidence: 99%

“…But, without specific symptoms, febrile illness diagnosis in returning travelers was challenging. Pull et al (2012) reported that cosmopolitan infections such as measles must be considered, even more as its incidence was increasing in several parts of the world. Kutsuna et al (2015) reported that clinical manifestations, simple laboratory test results, and regions of travel are helpful to distinguish between dengue, malaria, and enteric fever in febrile returning travelers with non-specific symptoms.…”

Section: Introductionmentioning

confidence: 99%

Aedes Aegypti and Dengue Virus Infections

Morsy

2018

Journal of the Egyptian Society of Parasitology

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Differential Diagnosis of Dengue Fever: Beware of Measles!: Table 1

Cited by 8 publications

References 13 publications

Principal Components Analysis Based Unsupervised Feature Extraction Applied to Gene Expression Analysis of Blood from Dengue Haemorrhagic Fever Patients

Principal Components Analysis Based Unsupervised Feature Extraction Applied to Gene Expression Analysis of Blood from Dengue Haemorrhagic Fever Patients

Real-Time PCR for Measles Virus Detection on Clinical Specimens with Negative IgM Result in Morocco

Aedes Aegypti and Dengue Virus Infections

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