Differential diagnosis of gastric cancer and gastritis: the role of contrast-enhanced ultrasound (CEUS)

Xue, Heng; Ge, Huiyu; Miao, Lei; Wang, Shumin; Zhao, Bo; Wang, Jinrui; Cui, Ligang

doi:10.1007/s00261-016-0952-z

Cited by 11 publications

(17 citation statements)

References 18 publications

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“…The qualitative assessment of enhancement patterns on CEUS clips was performed by the same operator in cases of a thickened gastric wall ≥6 mm only, since a thickness of less than 6 mm is too thin to perform an accurate analysis of the perfusion pattern. Moreover, even in human medicine, this type of analysis, performed in cases of gastritis and gastric neoplasia, has been reported only in ≥6-mm-thick gastric walls [ 34 , 35 ]. The enhancement patterns of thickened gastric walls considered are the same as those reported by Xue et al in the human medicine literature [ 34 ]: (1) enhancement degree, considering visible normal liver parenchyma as the reference.…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, even in human medicine, this type of analysis, performed in cases of gastritis and gastric neoplasia, has been reported only in ≥6-mm-thick gastric walls [ 34 , 35 ]. The enhancement patterns of thickened gastric walls considered are the same as those reported by Xue et al in the human medicine literature [ 34 ]: (1) enhancement degree, considering visible normal liver parenchyma as the reference. The relative enhancement of the lesion at contrast arrival was classified as hyper-, iso-, or hypoenhancement; (2) homogeneity of contrast uptake, classified as homogeneous or heterogeneous enhancement; (3) comb teeth-like vessels, consisting of parallel curvilinear structures representing arterial branching within the gastric wall on CEUS, classified as present or absent [ 34 ].…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…In human medicine, the CEUS technique has been used to perform qualitative and quantitative assessments of gastric wall perfusion in patients affected by gastritis and neoplastic disease [ 34 , 35 ]. One study reported that gastric cancer showed a diffuse enhancement without “comb teeth-like” vessels (parallel curvilinear structures representing arterial branching within the gastric wall), while this pattern was visible in most cases of gastritis; furthermore, the neoplastic wall showed delayed and lower peak enhancement compared to gastritis [ 34 ]. Another recent study evaluated standard B-mode US and CEUS in the characterization of malignant gastric tumours, reporting that the dynamics of the CM may be suggestive of the anatomopathological nature of the tumour: both adenocarcinomas and lymphomas showed a variable enhancement pattern followed by a delayed washout, while they differed in enhancement homogeneity; stromal tumours showed early arterial intense and homogenous enhancement followed by moderate washout in the venous phase [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

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B-Mode and Contrast Enhanced Ultrasonography Features of Gastric Inflammatory and Neoplastic Diseases in Cats

Simeoni

Terragni²,

Rubini³

et al. 2020

Animals

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Alimentary lymphoma (AL) is the most common malignancy of the feline gastrointestinal tract and may cause variable mild to severe alteration of the gastric wall on ultrasonography (US) that can be very similar to those caused by inflammation (INF). The aim of this prospective study is to establish the value of B-mode and contrast-enhanced US (CEUS) in describing specific features of normal, inflammatory, and neoplastic gastric diseases in feline species. B-mode US and CEUS of the stomach were performed in anesthetized cats with or without gastric disorders. Gastric wall qualitative and quantitative parameters were evaluated on B-mode US and CEUS examination. A total of 29 cats were included: six healthy (HEA) cats as the control group; nine INF; three low-grade lymphoma (LGAL); 10 high-grade lymphoma (HGAL). On B-mode US, there were significant differences in thickness, the wall’s layer definition and echogenicity between HGAL and all the other groups (<0.001). For CEUS, statistical differences between groups were found in the following: HGAL vs. HEA, HGAL vs. INF; HGAL vs. LGAL; INF vs. HEA. Diagnostic accuracy (AUC) and cut-off value were calculated and found to be significant for thickness (3.8 mm) for INF vs. LGAL (AUC > 0.70) and “benign” vs. “malignant” (AUC > 0.90) as well as peak enhancement (34.87 dB) for “benign” vs. “malignant” (AUC > 0.70). INF and LGAL showed an overlap of qualitative and quantitative parameters both on B-mode and CEUS, while HGAL usually appears as a severe wall thickening with absent layer definition, high-contrast uptake, a specific enhancement pattern, regional lymphadenopathy and local steatitis. Thickness and peak enhancement can be useful parameters in the characterization of gastric infiltrates in cats.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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B-Mode and Contrast Enhanced Ultrasonography Features of Gastric Inflammatory and Neoplastic Diseases in Cats

Simeoni

Terragni²,

Rubini³

et al. 2020

Animals

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“…The cause of death in patients with GC is mostly due to late diagnosis, rapid metastatic spread and the limited effectiveness of available therapeutics (2). As regards the diagnosis of GC, histopathological diagnosis remains the gold standard thus far; however, contrast-enhanced ultrasound is useful in the differential diagnosis of gastric subepithelial lesions and can guide further management and follow-up (3)(4)(5). Nevertheless, the identification of one or several genes as biomarkers for application in the non-invasive tumor molecular diagnosis of GC, and the better understanding of GC pathogenesis is essential for the establishment of diagnostic markers, as well as novel therapeutic methods.…”

Section: Introductionmentioning

confidence: 99%

Identification of significant biomarkers and pathways associated with gastric carcinogenesis by whole genome-wide expression profiling analysis

et al. 2018

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The incidence of gastric cancer (GC) is extremely high in East Asia. GC is also one of the most common and lethal forms of cancer from a global perspective. However, to date, we have not been able to determine one or several genes as biomarkers in the diagnosis of GC and have also been unable to identify the genes which are important in the therapy of GC. In this study, we analyzed all genome-wide expression profiling arrays uploaded onto the Gene Expression Omnibus (GEO) database to filtrate the differentially expressed genes (DEGs) between normal stomach tissues and GC tissues. GSE13911, GSE19826 and GSE79973 were based on the GPL570 platform, and GSE29272 was based on the GPL96 platform. We screened out the DEGs from the two platforms and by selecting the intersection of these two platforms, we identified the common DEGs in the sequencing data from different laboratories. Finally, we obtained 3 upregulated and 34 downregulated DEGs in GC from 384 samples. As the number of downregulated DEGs was greater than that of the upregulated DEGs, functional analysis and pathway enrichment analysis were performed on the downregulated DEGs. Through our analysis, we identified the most significant genes associated with GC, such as secreted phosphoprotein 1 (SPP1), sulfatase 1 (SULF1), thrombospondin 2 (THBS2), ATPase H+/K+ transporting beta subunit (ATP4B), gastric intrinsic factor (GIF) and gastrokine 1 (GKN1). The prognostic power of these genes was corroborated in the Oncomine database and by Kaplan-Meier plotter (KM-plotter) analysis. Moreover, gastric acid secretion, collecting duct acid secretion, nitrogen metabolism and drug metabolism were significantly related to GC. Thus, these genes and pathways may be potential targets for improving the diagnosis and clinical effects in patients with GC.

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Preoperative Tumor Staging of Gastric Cancer: Comparison of Double Contrast‐Enhanced Ultrasound and Multidetector Computed Tomography

Miao

et al. 2019

J of Ultrasound Medicine

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Objectives-The purpose of this study was to compare the sensitivity and specificity of double contrast-enhanced ultrasound (CEUS) and multidetector computed tomography (MDCT) in the preoperative tumor staging of gastric cancer (GC) to stratify patients for suitable treatment.Methods-Fifty-four patients with GC proved by histologic findings were included. The sensitivity and specificity of double CEUS and MDCT for tumor staging were calculated and compared. The differences between these methods were evaluated by using the area under the curve (AUC) from a receiver operating characteristic curve analysis.Results-There were no significant differences in AUC values for T1 and T2 stages between double CEUS and MDCT (P = .190 and .256, respectively). However, the sensitivity of double CEUS in the detection of the T1 stage was higher than that of MDCT (88% versus 75%). The AUC values of MDCT for T3 and T4 stages were 0.833 and 0.905, which were both significantly higher than those of double CEUS (0.759 and 0.696; P < .05). The sensitivities of double CEUS and MDCT for the T3 stage were both 89%, but the accuracy and specificity of double CEUS were lower than those of MDCT (76% versus 83% and 63% versus 78%). The specificities of double CEUS and MDCT for the T4 stage were both 98%, but the accuracy and sensitivity of double CEUS were lower than those of MDCT (85% versus 94% and 42% versus 83%).Conclusions-Multidetector CT is superior to double CEUS for T3 and T4 GC, and double CEUS may be regarded as an important complementary method to MDCT.

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Differential diagnosis of gastric cancer and gastritis: the role of contrast-enhanced ultrasound (CEUS)

Abstract: Our results demonstrated the usefulness and accuracy of US and CEUS in differential diagnosis of gastric cancer and gastritis. CEUS has the potential to make the diagnosis more accurate.

Cited by 11 publications

References 18 publications

B-Mode and Contrast Enhanced Ultrasonography Features of Gastric Inflammatory and Neoplastic Diseases in Cats

B-Mode and Contrast Enhanced Ultrasonography Features of Gastric Inflammatory and Neoplastic Diseases in Cats

Identification of significant biomarkers and pathways associated with gastric carcinogenesis by whole genome-wide expression profiling analysis

Preoperative Tumor Staging of Gastric Cancer: Comparison of Double Contrast‐Enhanced Ultrasound and Multidetector Computed Tomography

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