Differential Diagnosis of Hürthle Cell Neoplasms on Fine Needle Aspirates

Pambuccian, Stefan E.; Becker, Robert; Ali, Syed Z.; Savik, Kay; Rosenthal, Dorothy L.

doi:10.1159/000332323

Cited by 18 publications

(14 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10,17,19 Some have even attempted to distinguish Hurthle cell adenomas from Hurthle cell carcinomas, irrespective of the histologic gold standard-capsular and/or vascular invasion-needed to establish the diagnosis of Hurthle cell carcinomas. 9,15,21 This lack of agreement on the usefulness of specific features is due, in part, to the small numbers of cases examined in previous studies as well as to the limited application of statistical analysis in these studies. In an effort to identify an accurate set of criteria for the cytologic diagnosis of HCN, we conducted what is to our knowledge the largest morphologic study of 14 features encountered in Hurthle cell lesions.…”

mentioning

confidence: 99%

Fine-needle aspiration biopsy of Hurthle cell lesions of the thyroid gland

Elliott

Pitman

Bloom

et al. 2006

Cancer

109

View full text Add to dashboard Cite

The aim of this study was twofold. The first aim was to estimate the diagnostic reliability of urinary cytology for detection and management of urothelial neoplasms by using a specific preserving fluid for sample collection, and the liquid‐based thin layer method for specimen preparation, the estimate was based on the correlation between the cytological findings of 10,000 non‐hospitalized patients, and their histological diagnoses. A second aim was to compare the reliability of two instruments for thin‐layer preparation, i.e., TP2000, TP3000, capable of processing the specimens at very different rates. The preservation of cell structure is ameliorated by the procedure of sample collection and treatment here described. This allows a more accurate reading of LBC slides as shown by: (a) the significant concordance between cytological and histological diagnosis (92%); (b) the significant number of low‐grade urothelial carcinomas (20.5%) revealed by urinary cytology and validated by histologic diagnosis; (c) the low rate (8%) of misjudgement of cytological diagnosis reached in this study. The quality of performances of the two instruments tested for thin‐layer preparation, i.e., TP2000 and TP3000, is statistically comparable. We recommend the procedure that makes use of preserving fluid for sample collection (cytolyt™) and treatment (preservcyt ™) as here described. We also recommend the use of thin‐layer method for specimen preparation since it allows a more uniform distribution of the cells on the support with reduction of overlapping phenomena. Finally, economic considerations suggest the preferential use of Thin Prep 3000. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.

show abstract

mentioning

confidence: 99%

Fine-needle aspiration biopsy of Hurthle cell lesions of the thyroid gland

Elliott

Pitman

Bloom

et al. 2006

Cancer

109

View full text Add to dashboard Cite

show abstract

“…Admittedly, it is not possible via conventional light microscopy to precisely pinpoint numerical differences in a single morphometric variable such as nucleolar form factor, which correctly typed 17 of 19 (89%) of Hürthle cell tumors in a recently published retrospective morphometric study. 25 We think, however, that equal weight given to each of the 10 components of the total score in our light microscopic study affords diagnostic accuracy at least comparable to that of morphometry. This is evidenced by correct typing of 11 of 13 (85%) Hürthle cell tumors.…”

Section: Abmentioning

confidence: 73%

“…However, even these features, according to the authors, were not reliable on a case-by-case basis. 25 This study provided strong evidence that even with precise measurements of well-defined cellular characteristics, made possible by modern-day morphometric equipment, no one, particular cellular feature can be relied upon to discern benign from malignant oncocytic cells in a given thyroid FNA. After a review of the contemporary literature, we think that no one, particular molecular or cytomorphometric feature has distinguished itself as pathognomonic for oncocytic carcinoma.…”

Section: Objective: To Assess Whether a Light Microscopic Semiquantimentioning

confidence: 84%

“…The negative predictive value of malignancy of a total score for Hürth-le cell adenomas equal to or less than the mean plus cells and breast apocrine metaplastic cells in benign and malignant lesions utilizing semiquantitative, light microscopic analysis based on quantitative features that were thought to be statistically significant in the recently published morphometric study mentioned above. 25 In doing so, we hoped to find reliable criteria based on standard light microscopy alone to distinguish between benign and malignant oncocytic cells obtained from thyroid and breast FNAs in order to aid mainstream pathologists and cytopathologists, who may have limited access to sophisticated and costly molecular techniques and morphometric analysis.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Differential Diagnosis of Oncocytic Lesions of the Breast and Thyroid Utilizing a Semiquantitative Approach

et al. 1999

View full text Add to dashboard Cite

“…Histiocytes can also be seen prominently in reactive lymph nodes. Several authors have reported the utility of morphometry in differentiating benign from malignant cells in various organs like the liver and thyroid as well as in effusions (pleural fluid) [33,34,35]. …”

Section: Discussionmentioning

confidence: 99%

Cytomorphological and Morphometric Analysis of 22 Cases of Rosai-Dorfman Disease: A Large Series from a Tertiary Care Centre

Mallick

Ghosh²,

Iyer³

et al. 2013

Acta Cytologica

View full text Add to dashboard Cite

Background: Rosai-Dorfman disease (RDD) is a rare benign idiopathic histiocytic proliferation. Most commonly reported cases are lymph nodal. Only 30-40% of cases occur in extranodal sites. Although the morphological features of RDD are well documented, there is limited information about the morphometric variations in the histiocytes of this entity. Method: Twenty-two cases of RDD diagnosed on fine-needle aspiration cytology (FNAC) were retrieved from the archives. Both Papanicolaou- and May-Grünwald-Giemsa-stained slides were available for evaluation in all cases. Nuclear area, diameter and histiocyte size were measured taking reactive histiocytes as controls. Results: Among the 22 patients (male/female ratio 3:2; age range 5-55 years, mean 26 years), 3 cases were extranodal and 19 cases were nodal. The nodal sites included cervical, axillary, inguinal and submandibular lymph nodes. The extranodal sites were the retroperitoneum, mediastinum and skin. The most common clinical presentation was enlarged lymph nodes. Cytological features included numerous large benign histiocytes with emperipolesis. All the morphometric parameters were significantly (p < 0.01) higher in RDD histiocytes than in histiocytes in the reactive lymph node. Conclusions: In view of the rarity of the disease and the variable clinical presentation in RDD, accurate diagnosis is necessary. This is the first study to document the morphometric parameters of RDD histiocytes and their comparison with histiocytes in the reactive lymph node.

show abstract

Differential Diagnosis of Hürthle Cell Neoplasms on Fine Needle Aspirates

Cited by 18 publications

References 44 publications

Fine-needle aspiration biopsy of Hurthle cell lesions of the thyroid gland

Fine-needle aspiration biopsy of Hurthle cell lesions of the thyroid gland

Differential Diagnosis of Oncocytic Lesions of the Breast and Thyroid Utilizing a Semiquantitative Approach

Cytomorphological and Morphometric Analysis of 22 Cases of Rosai-Dorfman Disease: A Large Series from a Tertiary Care Centre

Contact Info

Product

Resources

About