Differential diagnosis of immunoglobulin G4-related sialadenitis and Kimura’s disease of the salivary gland: a comparative case series

Zhu, Wenxuan; Zhang, Y.-Y.; Sun, Zhipeng; Gao, Yan; Chen, Y.; Yu, Guang‐Yan

doi:10.1016/j.ijom.2020.05.023

Cited by 14 publications

(18 citation statements)

References 31 publications

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“…These demographic, clinical, histological, and biochemical similarities and differences are summarized in Table 1 . Compared with IgG4RD, KD shows a more prominent male dominance and wider distribution of age at onset, with the median age in the third to fourth decade, and the lumps in KD are rarely outside the head and neck region [ 4 , 5 , 8 , 13 , 17 ]. According to the 2019 ACR/EUALR criteria, IgG4RD typically affects the pancreas, salivary glands, bile ducts, orbits, kidney, lung, aorta, retroperitoneum, pachymeninges, or thyroid gland [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…According to the 2019 ACR/EUALR criteria, IgG4RD typically affects the pancreas, salivary glands, bile ducts, orbits, kidney, lung, aorta, retroperitoneum, pachymeninges, or thyroid gland [ 18 ]. It shows a smaller overall middle-aged-male predominance, with the median age in the fifth to the sixth decade and female predominance in IgG4-related sialadenitis and dacryoadenitis [ 11 , 13 , 17 , 19 , 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…Tissue eosinophil infiltration is ubiquitous in KD but only found in approximately 50% of patients with IgG4RD [ 13 , 20 , 22 ]. Eosinophilic abscesses were observed in 74% of patients with KD [ 13 , 17 ], whereas only one patient with IgG4RD reported an eosinophilic abscess [ 13 ]. Moreover, IgG4(+) plasma cell infiltration can occur in KD.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Clinical Manifestations and Pathology between Kimura Disease and IgG4-Related Disease: A Report of Two Cases and Literature Review

Chang

Lee

Chang

et al. 2022

JCM

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Kimura disease (KD) is a rare, chronic proliferative condition presenting as a subcutaneous mass predominantly located in the head and neck region; it is characterized by eosinophilia and elevated serum IgE levels. IgG4-related disease (IgG4RD) is a fibroinflammatory condition characterized by swelling in single or multiple organs and the infiltration of IgG4 plasma cells. Herein, we presented two cases. Case 1 is a 38-year-old man with a painless mass in his right postauricular region, and Case 2 is a 36-year-old man with painless lymphadenopathy in his bilateral postauricular region. After surgical excision, they showed good recovery with no relapse. Although Cases 1 and 2 shared several overlapping pathological manifestations, there were a few differences that allowed the differentiation of KD and IgG4RD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Comparison of Clinical Manifestations and Pathology between Kimura Disease and IgG4-Related Disease: A Report of Two Cases and Literature Review

Chang

Lee

Chang

et al. 2022

JCM

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“…In recent years, a group of salivary gland inflammatory diseases with elevated serum or tissue immunoglobulin E (IgE) has been discovered. The group includes IgG4‐related sialadenitis (IgG4‐RS), 1 Kimura's disease involved salivary gland, 2,3 and eosinophilic sialodochitis (ES), 4 which could be jointly named hyper‐IgE‐related salivary gland diseases. These diseases share clinicopathological features such as salivary gland enlargement, comorbidity with allergic diseases, elevated serum IgE, peripheral blood eosinophilia, tissue lymphoplasmacytic infiltration, and increased IgE‐positive cell infiltration 5–7 .…”

Section: Introductionmentioning

confidence: 99%

“…12,13 IgG4-related disease is a multi-organ immunemediated disease. 1 Kimura disease is a chronic inflammatory granulomatous disease-related to immune-mediated disorder, 2,3 and ES manifests as a specific type of sialadenitis related to allergy. 4 These diseases could be regarded as secondary hyper-IgE-related salivary gland diseases.…”

Section: Introductionmentioning

confidence: 99%

Primary Hyper‐IgE‐Related Salivary Gland Disease: A New Disease Entity

Zhu¹,

Zhang²,

Gao

et al. 2022

The Laryngoscope

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Objectives To clarify the clinicopathological characteristics of primary hyper‐IgE‐related salivary gland disease (PHIESD), which is a newly proposed entity. Methods Fifteen consecutive patients pathologically diagnosed with chronic sialadenitis were enrolled, and their clinicopathological features were comprehensively analyzed. Inclusion criteria: (1) multiple salivary gland enlargement; (2) elevated serum IgE and/or IgE‐positive cell infiltration in salivary gland tissues; (3) histology‐confirmed lymphoplasmacytic infiltration; (4) exclusion of other known diseases. Results The male‐to‐female ratio was 5:10. The median age was 21 (range, 3–63) years. The average number of affected glands was 3.7 ± 1.4. Submandibular, parotid, and sublingual glands were involved in 15, 8, and 2 patients, respectively. Comorbid diseases included allergic diseases in seven patients and autoimmune diseases in two. Elevated serum IgE (median 175 kU/L) was seen in all patients. Serum IgG4 was slightly elevated in three patients. Histologically, most patients had mild lesions, including mild lymphocyte infiltration (60%) and focal fibrosis (66.7%). Lymphoid follicular formation (53.3%), moderate to severe lymphocytic inflammation (40%) and severe fibrosis (33.3%) were also observed. Immunohistochemically, IgE‐positive cells infiltrated mainly around the ducts, with scattered infiltration of IgG4‐positive, mast, and interleukin‐4 positive cells. During follow‐up (median, 46 months) of ten patients without intervention and two with immunosuppressive therapy, no significant changes in gland size or serum IgE level were noted. Conclusions PHIESD manifests as homogeneous enlargement of multiple salivary glands and elevated serum IgE. Histopathology further verifies the diagnosis. It might be associated with anaphylaxis or autoimmune dysfunction. Conservative treatment is suggested. Level of Evidence 4 Laryngoscope, 132:2132–2138, 2022

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Lymph Nodes and the Salivary Glands

Mandel

2024

Clinical Management of Salivary Gland Disorders

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Differential diagnosis of immunoglobulin G4-related sialadenitis and Kimura’s disease of the salivary gland: a comparative case series

Cited by 14 publications

References 31 publications

Comparison of Clinical Manifestations and Pathology between Kimura Disease and IgG4-Related Disease: A Report of Two Cases and Literature Review

Comparison of Clinical Manifestations and Pathology between Kimura Disease and IgG4-Related Disease: A Report of Two Cases and Literature Review

Primary Hyper‐IgE‐Related Salivary Gland Disease: A New Disease Entity

Lymph Nodes and the Salivary Glands

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