Differential diagnosis of leiomyoma in pregnancy: rapid growth, rapid regression and progestogenic effects

Scuderi, Raffaele; Giovannini, Massimo; Villani, Vittorio; Canino, T.; Antonaci, Domenico

doi:10.1002/uog.15677

Cited by 4 publications

(3 citation statements)

References 2 publications

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“…Two studies reported a rapid increase in leiomyoma size during pregnancy, which resulted in high abdominal pressure and intrauterine growth restriction, requiring the patients to undergo an elective cesarean section and iatrogenic preterm labor 14 . Leiomyoma may increase from 7 to 20 cm at 15 weeks of gestation, resulting in leiomyoma pedicular torsion and myomectomy during pregnancy 15 and may shrink from 17 to 5.2 cm after first‐trimester termination 16 . Although these studies show the prominent effect of pregnancy on leiomyoma, recent research has shown that the size of leiomyoma changes occasionally during pregnancy, and most of them do not increase or even shrink postpartum 17 …”

Section: Discussionmentioning

confidence: 99%

“…14 Leiomyoma may increase from 7 to 20 cm at 15 weeks of gestation, resulting in leiomyoma pedicular torsion and myomectomy during pregnancy 15 and may shrink from 17 to 5.2 cm after first-trimester termination. 16 Although these studies show the prominent effect of pregnancy on leiomyoma, recent research of pregnant women with multiple leiomyomas in which at least one leiomyoma had a maximum diameter of more than 1 cm. Leiomyoma sizes were followed up at 11-14, 20-22, and 32-34 weeks of pregnancy.…”

Section: Leiomyoma Change During Pregnancymentioning

confidence: 95%

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Change of uterine leiomyoma size during pregnancy and the influencing factors: A cohort study

Tian

Wang

et al. 2021

Intl J Gynecology & Obste

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Uterine leiomyoma is the most common pelvic benign tumor in women of reproductive age, and its prevalence is known to increase with age. 1 The prevalence of leiomyoma in pregnancy is 2.8%-16.7%. [2][3][4] As a result of the limitation that physical examination and ultrasound examination focuses on the fetus instead of the leiomyoma for pregnant women, the prevalence may be underestimated. With advanced age at pregnancy, the increasing obesity rate, and the implemented three-child policy in China, the prevalence of leiomyoma during pregnancy is increasing.It is commonly believed that uterine leiomyoma appears to negatively impact perinatal outcomes. 5 Women with pregnancies complicated by leiomyoma may need to undergo prenatal myomectomy

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Section: Discussionmentioning

confidence: 99%

Section: Leiomyoma Change During Pregnancymentioning

confidence: 95%

Change of uterine leiomyoma size during pregnancy and the influencing factors: A cohort study

Tian

Wang

et al. 2021

Intl J Gynecology & Obste

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“…Uterine leiomyoma has been reported to depend on hormones release; Scuderi et al [10] in 2016 described a spontaneous regression of pulmonary leiomyomas during pregnancy, so, cure consists of hysterectomy with oophorectomy [11] added to hormonal therapy on the basis of the estrogen and progesteron receptor expression.…”

Section: [9]mentioning

confidence: 99%

Benign leiomyoma metastasizing to the lung: a case report and a brief review of the literature

Lazzari¹,

Perri²,

Scarpati³

et al. 2017

JUMD

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The authors have investigated a rare clinical condition consisting of a benign metastatic leiomyoma (BML) spreading in the lung, in a young woman. A 42-year-old woman affected by multiple pulmonary nodules histologically diagnosed as metastases from uterine sarcoma (one of them has been resected in the past and a pathologic diagnosis of uterine leyomiosarcoma was done) in concomitance with uterine bleeding, was referred to the Radiation Oncology Department of Taranto (Italy) Hospital, with the aim to perform an hemostatic radiotherapy after 4 cycles of induction chemotherapy. The patients underwent a myomectomy 9 years before. An accurate tissue samples review was performed both on myomectomy sample and on lung specimens, and as result, a diagnosis of BML was done, mainly on the basis of the mitotic activity. The patient was successfully treated with hysterectomy and oophorectomy followed by megestrol therapy, and a partial remission of the lung disease was obtained. Pulmonary metastatic leiomyomatosis should be considered in a premenopausal woman bearing a uterine myoma. The evaluation of the mitotic activity should be considered as the most reliable feature available to distinguish BML from uterine sarcoma. Key words:Leiomyoma, mitotic activity, uterine myoma, lung metastases, megestrol ABSTRACTArticle history:

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Spontaneous rupture of infarcted leiomyoma into endometrial cavity in a perimenopausal woman

Huang

Chao

et al. 2017

Arch Gynecol Obstet

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Differential diagnosis of leiomyoma in pregnancy: rapid growth, rapid regression and progestogenic effects

Cited by 4 publications

References 2 publications

Change of uterine leiomyoma size during pregnancy and the influencing factors: A cohort study

Change of uterine leiomyoma size during pregnancy and the influencing factors: A cohort study

Benign leiomyoma metastasizing to the lung: a case report and a brief review of the literature

Spontaneous rupture of infarcted leiomyoma into endometrial cavity in a perimenopausal woman

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