Differential Diagnosis of Movement Disorders in Clinical Practice

Rana, Abdul Qayyum; Hedera, Peter

doi:10.1007/978-3-319-01607-8

Cited by 3 publications

(1 citation statement)

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“…The rest and postural tremor signals captured by the sensors show peak frequencies at 3.5 and 4.3 Hz, respectively, in accordance with the typical frequency range (3−7 Hz) of parkinsonian tremor (Figure S8). 55 These quantitative data could be stored and categorized into specific patients and used as feedback to the corresponding therapy. The proposed OS 2 is of low cost and easy-to-use in clinical practices so that the patients may perform the test themselves at home, while the clinicians can get access to the data to evaluate the progression of PD and patients' response to medications remotely.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Stretchable and Highly Sensitive Optical Strain Sensors for Human-Activity Monitoring and Healthcare

Guo

Zhou

Zong³

et al. 2019

ACS Appl. Mater. Interfaces

128

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Flexible and stretchable strain sensors are essential to developing smart wearable devices for monitoring human activities. Such sensors have been extensively exploited with various conductive materials and structures, which, however, are normally in need of complex manufacturing processes and confronted with the challenge to achieve both large stretchability and high sensitivity. Here, we report a simple and low-cost optical strategy for the design of stretchable strain sensors which are capable of measuring large strains of 100% with a low detection limit (±0.09%), a fast responsivity (<12 ms), and high reproducibility (over 6000 cycles). The optical strain sensor (OS2) is fabricated by assembling plasmonic gold nanoparticles (GNPs) in stretchable elastomer-based optical fibers, where a core/cladding structure with step-index configuration is adopted for light confinement. The stretchable, GNP-incorporated optical fiber shows strong localized surface plasmon resonance effects that enable sensitive and reversible detection of strain deformations with high linearity and negligible hysteresis. The unique mechanical and sensing properties of the OS2 enable its assembling into clothing or mounting on skin surfaces for monitoring various human activities from physiological signals as subtle as wrist pulses to large motions of joint bending and hand gestures. We further apply the OS2 for quantitative analysis of motor disorders such as Parkinson’s disease and demonstrate its compatibility in strong electromagnetic interference environments during functional magnetic resonance imaging, showing great promises for diagnostics and assessments of motor neuron diseases in clinics.

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Section: ■ Results and Discussionmentioning

confidence: 99%