Differential diagnosis of verrucous carcinoma in the oral cavity and larynx

Schrader, Merle; Laberke, H. G.

doi:10.1017/s002221510010619x

Cited by 25 publications

(20 citation statements)

References 21 publications

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“…12 The main histopathological differential diagnosis of verrucous carcinoma is from leukoplakia, papilloma, pseudoepitheliomatous hyperplasia, verrucous hyperplasia and highly differentiated squamous cell carcinoma. 13 Treatment of verrucous carcinoma remains controversial. Surgery is the mainstay of treatment of this neoplasm.…”

Section: Discussionmentioning

confidence: 99%

Sinonasal Verrucous Carcinoma

Qazi¹,

Iqbal²,

Aneesa³

et al. 2012

International Journal of Head and Neck Surgery

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Section: Discussionmentioning

confidence: 99%

Sinonasal Verrucous Carcinoma

Qazi¹,

Iqbal²,

Aneesa³

et al. 2012

International Journal of Head and Neck Surgery

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“…Buccal mucosa cancer was graded as follows: i) well-differentiated carcinoma, cells resembling the adjacent benign squamous epithelium; ii) moderately-differentiated carcinoma, cells forming large anastomosing areas in which keratin pearls are formed, they are not numerous and the main component consists of cells with pronounced cytonuclear atypia; and iii) poorly-differentiated carcinoma, cells that have lost the majority of their squamous epithelial characteristics and architecture (11). …”

Section: Methodsmentioning

confidence: 99%

Antimutagenic activity and preventive effect of black tea on buccal mucosa cancer

et al. 2013

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A black tea product was evaluated for anti-mutagenic and in vivo anticancer effects. At concentrations of 1.25 and 2.5 mg/plate, black tea exhibited anti-mutagenicity with N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) in the Salmonella typhimurium TA100 strain. A Kunming (KM) mouse buccal mucosa cancer model was established by injecting mice with U14 squamous cell carcinoma cells. Following injection, the wound at the injection site was smeared with black tea. It was observed that the tumor volumes for the groups treated with different concentrations of black tea were smaller than the control groups. The sections of buccal mucosa cancer tissue showed that cancer development in the black tea groups was weaker compared with that in the control group. Similar results were observed in the lesion section of the cervical lymph. Using reverse transcription polymerase chain reaction (RT-PCR), the black tea groups demonstrated an increase in Bcl-2-associated X protein (Bax) and a decrease in B cell lymphoma-2 (Bcl-2) expression, compared with the control groups. The results demonstrated that black tea had an improved antimutagenic effect and in vivo buccal mucosa cancer preventive activity compared with the untreated control in mice.

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“…Buccal mucosa cancer was graded as follows: i) well-differentiated carcinoma: cells resemble the adjacent benign squamous epithelium; ii) moderately differentiated carcinoma: cells form large anastomosing areas in which keratin pearls are formed, they are not numerous and the main component consists of cells with pronounced cytonuclear atypia and iii) poorly differentiated carcinoma: cells have lost the majority of their squamous epithelial characteristics and architecture (12). …”

Section: Methodsmentioning

confidence: 99%

Purple bamboo salt has anticancer activity in TCA8113 cells in vitro and preventive effects on buccal mucosa cancer in mice in vivo

Zhao

Deng

Park

et al. 2012

Experimental and Therapeutic Medicine

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Bamboo salt is a traditional healthy salt known in Korea. The in vitro anticancer effects of the salt were evaluated using a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) assay in TCA8113 human tongue carcinoma cells. At 1% concentration, the growth inhibitory rate of purple bamboo salt was 61% higher than that of sea salt (27%). Apoptosis analysis of the cancer cells was carried out using 4,6-diamidino-2-phenylindole (DAPI) staining to investigate the mechanism of the anticancer effects in tongue carcinoma cells. Purple bamboo salt induced a stronger apoptotic effect than sea salt. An Institute of Cancer Research (ICR) mouse buccal mucosa cancer model was established by injecting mice with U14 squamous cell carcinoma cells. Following injection, the wound at the injection site was smeared with salt samples. It was observed that the tumor volumes for the group treated with purple bamboo salt were smaller than those from the sea salt treatment and control groups. The sections of buccal mucosa cancer tissue showed that canceration in the purple bamboo salt group was weaker compared with that in the sea salt group. Similar results were observed in the lesion section of the cervical lymph. Using reverse transcription-polymerase chain reaction (RT-PCR) and western blotting, the purple bamboo salt group demonstrated an increase in Bcl-2-associated X protein (Bax) and a decrease in B cell lymphoma-2 (Bcl-2), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression, compared with the sea salt and control groups. The results demonstrated that purple bamboo salt had improved in vivo buccal mucosa cancer preventive activity compared with sea salt in mice.

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Differential diagnosis of verrucous carcinoma in the oral cavity and larynx

Cited by 25 publications

References 21 publications

Sinonasal Verrucous Carcinoma

Sinonasal Verrucous Carcinoma

Antimutagenic activity and preventive effect of black tea on buccal mucosa cancer

Purple bamboo salt has anticancer activity in TCA8113 cells in vitro and preventive effects on buccal mucosa cancer in mice in vivo

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