Differential distribution of cholesterol pools across arteries under high-cholesterol diet

Schneider, Elizabeth; Fitzgerald, Amanda C.; Ponnapula, Supriya; Dopico, Alex M.; Bukiya, Anna N.

doi:10.1016/j.bbalip.2022.159235

Cited by 5 publications

(2 citation statements)

References 79 publications

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“…Cholesterol can be incorporated into RVFV particles and enhance RVFV infectivity in a polyamine-dependent manner ( 88 ). Studies have found that a high-cholesterol diet can lead to liver cholesterol accumulation, and it mainly affects cerebral vessels among the vascular effects, with up-regulation of LDLr and LRP1 detected in cerebral vessels ( 89 ). This finding aligns with the liver and brain lesions caused by RVFV infection, but the specific relationship still requires further exploration.…”

Section: Conclusion and Prospectmentioning

confidence: 99%

Natural hosts and animal models for Rift Valley fever phlebovirus

Xu,

Wang,

Jiang

et al. 2023

Front. Vet. Sci.

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Rift Valley fever phlebovirus (RVFV) is a zoonotic mosquito-transmitted arbovirus, presenting a serious threat to humans and animals. Susceptible hosts are of great significance for the prevention of RVFV. Appropriate animal models are helpful to better understand the onset and development of diseases, as well as the control measures and vaccine research. This review focuses on the role of animal hosts in the maintenance of the virus, and summarizes the host range of RVFV. We list some common animal models in the process of RVFV research, which would provide some important insights into the prevention and treatment of RVFV, as well as the study of Rift Valley fever (RVF) pathogenesis and vaccines.

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Section: Conclusion and Prospectmentioning

confidence: 99%

Natural hosts and animal models for Rift Valley fever phlebovirus

Xu,

Wang,

Jiang

et al. 2023

Front. Vet. Sci.

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“…Kolesterol berlebihan merupakan faktor risiko utama untuk penyakit pembuluh darah. Di dalam sel, kolesterol didistribusikan dalam fraksi yang sensitif terhadap deterjen dan tahan deterjen, dengan jumlah kolesterol terbesar yang berada di membran seluler (Schneider et al, 2022). Penyimpangan dalam metabolisme kolesterol terjadi pada berbagai kanker manusia.…”

Section: Pendahuluanunclassified

Peningkatan Kadar Kolesterol dan Usia Pada Ibu Rumah Tangga

Husen¹,

Ratnaningtyas²,

Khasanah³

et al. 2022

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Pendahuluan Kolesterol merupakan lemak hasil metabolit yang mengandung senyawa sterol dan banyak terkonsentrasi pada membran sel di dalam tubuh serta sistem sirkulasi. Tujuan Mengetahui kadar Kolesterol total pada ibu rumah tangga (IRT) berdasarkan kategori rentang usia 25 – 80 tahun dan hubungan peningkatkan kadar Kolesterol total dengan usia IRT. Metode Penelitian adalah deskriptif analitis dengan pendekatan corss-sectional method, dengan total sampel 30 dan teknik pengambilan sampel adalah purposive sampling method. Data hubungan level kolesterol total dan usia dianalisis secara statistik dengan analisis bivariate dengan indeks pearson correlation pada SPSS software. Hasil studi menunjukkan IR rata-rata level kolesterol 198.07 mg/dL, dan rata-rata usia 47.87 tahun. Terdapat 50% responden memiliki kadar kolesterol baik, 26.67% kategori perbatasan, dan 23.33% kategori bahaya dengan level kolesterol tertinggi 297 mg/dL dan terendah 130 mg/dL. Kesimpulan Kadar kolesterol total pada IRT di Kelurahan Tanjung, Purwokerto Selatan menunjukkan bahwa terdapat hubungan yang kuat antara peningkatan kadar kolestrol di dalam tubuh dengan penambahan usia

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Efficacy of a mixed extract ofSalvia miltiorrhizaandPaeonia lactiflorain inhibiting the aging of vascular wall throughin vitroandin vivoexperiments

Son,

Cha,

Song

et al. 2024

Bioscience, Biotechnology, and Biochemistry

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Vascular wall aging has been strongly associated with cardiovascular diseases. Thus, this study aimed to investigate the efficacy of USCP-GVH-014, a mixed extract of Salvia miltiorrhiza Bunge and Paeonia lactiflora Pall., in inhibiting vascular wall aging through in vitro and in vivo experiments. The results revealed that USCP-GVH-014 inhibited abnormal cell proliferation, collagen overproduction, and MMP-2 and MMP-9 overexpression caused by various stimuli and recovered the antioxidant enzyme superoxide dismutase on human aortic smooth muscle cells. In addition, it inhibited the increase in ICAM-1 and VCAM-1 expression induced by tumor necrosis factor alpha on human aortic endothelial cells and prevented the aging of the vascular wall by regulating related proteins such as epidermal growth factor and interleukin-1 beta. Furthermore, it reduced vascular aging in in vivo studies. These results demonstrate that USCP-GVH-014 effectively reduces vascular aging, thereby rendering it a potential therapeutic candidate for cardiovascular diseases.

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Differential distribution of cholesterol pools across arteries under high-cholesterol diet

Cited by 5 publications

References 79 publications

Natural hosts and animal models for Rift Valley fever phlebovirus

Natural hosts and animal models for Rift Valley fever phlebovirus

Peningkatan Kadar Kolesterol dan Usia Pada Ibu Rumah Tangga

Efficacy of a mixed extract ofSalvia miltiorrhizaandPaeonia lactiflorain inhibiting the aging of vascular wall throughin vitroandin vivoexperiments

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