Differential Distribution of Type IV Collagen .ALPHA.1 to .ALPHA.6 Chains Suggests Distinct Molecular Interaction between the Epithelial and Mesenchymal Components of Benign Odontogenic Tumors

Han, Phuu Pwint; Tamamura, Ryo; Katase, Naoki; Fujii, Eiki; Okauchi, Mika; Tan, Ji; Xiao, Jing; Siar, Chong Huat; Nagatsuka, Hitoshi

doi:10.2485/jhtb.15.46

Cited by 6 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HS chains were strongly localized in the stroma of ameloblastic carcinoma in contrast to their confined localization in epithelial nests of ameloblastoma. Similar findings were reported in ovarian cancer, breast cancer and head and neck squamous cell carcinoma (28)(29)(30)(31)(32). It was suggested that loss or reduction of HS immunoex pression from cancer cells leads to decreased intercellular cohesion and increased potential for tumor invasion and metastasis.…”

Section: Ameloblastoma Vs Ameloblastic Carcinomasupporting

confidence: 75%

Heparanase and its related molecules in odontogenic tumors

et al. 2009

Self Cite

View full text Add to dashboard Cite

Heparan sulphate proteoglycans (HSPGs) constitute a group of ubiquitous macromolecules of cell surface and extracellular matrices (ECM). HS chains of HSPGs can bind numerous molecules including growth factors, cytokines and chemokines. Thus the degradation of HS chains by endoglycosidases will affect profoundly cell function. Heparanase is a mammalian endo-β-glucuronidase enzyme capable of selectively degrading HS chains. Aside from the enzymatic functions, heparanase is preferentially expressed by human tumors, and its over-expression in tumor cells provides invasive phenotype. We previously reported that heparanase expression and the HS-bound molecules are important for odontogenesis and development of odontogenic tumors. It can be concluded that the growth and progression of benign and malignant odontogenic tumors are related to the deranged immunoexpression and localization of HS and heparanase molecules and that heparanase may be responsible for growth and progression of odontogenic tumors by modulating the availability and function of HS binding growth factors.

show abstract

Section: Ameloblastoma Vs Ameloblastic Carcinomasupporting

confidence: 75%

Heparanase and its related molecules in odontogenic tumors

et al. 2009

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the present study, desmoplastic ameloblastoma showed a higher expression of Collagen IV as compared to the other variants [Table/ Fig-4b]. Phuu Pwint Han et al, [13] also found a higher expression of type IV collagen in desmoplastic ameloblastoma in comparison to the other variants of ameloblastoma. In the present study two out of five cases of unicystic ameloblastoma showed a total absence of collagen IV expression.…”

Section: Discussionmentioning

confidence: 48%

Immunohistochemical expression of Type IV Collagen and Autocrine Motility Factor Receptor in Odontogenic Tumours

Grewal

Sethi

2014

JCDR

View full text Add to dashboard Cite

“…Hyp‐Leu, also known as 4‐hydroxyprolyl‐leucine, is a dipeptide structure with a hydroxyprolyl residue that was mainly biosynthesized via the catalysis mediated by prolyl hydroxylase . Hydroxyproline has been demonstrated as a building block of collagen, making it a critical player in tumor growth and differentiation during the development of cancers . Particularly, the hydroxylation of prolyl was proven to participate in the process of targeting hypoxia‐inducible factor (HIF), overexpression of which was closely associated with increased vascular density, tumor severity, treatment failure and a poor prognostic outcome with conventional therapies .…”

Section: Discussionmentioning

confidence: 99%

“…36 Hydroxyproline has been demonstrated as a building block of collagen, making it a critical player in tumor growth and differentiation during the development of cancers. 37,38 Particularly, the hydroxylation of prolyl was proven to participate in the process of targeting hypoxia-inducible factor (HIF), overexpression of which was closely associated with increased vascular density, tumor severity, treatment failure and a poor prognostic outcome with conventional therapies. 39,40 Therefore, excellent prognostic performance of Hyp-Leu might be associated with up-regulated hydroxylation of prolyl-residues during EOC development and may provide clinicians with a potential therapeutic target for improving the prognosis of EOC.…”

Section: Discussionmentioning

confidence: 99%

Selection of small plasma peptides for the auxiliary diagnosis and prognosis of epithelial ovarian cancer by using UPLC/MS‐based nontargeted and targeted analyses

Xia

Bai

et al. 2019

Intl Journal of Cancer

View full text Add to dashboard Cite

Epithelial ovarian cancer (EOC) is the leading cause of gynecologic cancer-related death due to its non-specific characteristics compared to benign cases and poor prognosis after conventional therapies. Small peptides (SPs) demonstrated to have potential for diagnosis and prognosis were focused on in this study for the discovery of biomarkers that address these issues. Metabolic profiles of fifteen SPs, including nine dipeptides and six tripeptides were acquired from plasma samples of 140 EOC and 158 benign ovarian tumor (BOT) patients. Partial least square discriminant analysis showed separations between EOC and BOT subjects of different age brackets. Hyp-Leu, Glu-Trp and Phe-Phe were selected as promising predictive SP-biomarkers for better EOC diagnosis compared to conventional biomarkers. Combined Hyp-Leu, Glu-Trp and CA125 presented an area under the curve (AUC) of 0.904, with a sensitivity and specificity of 0.804 and 0.944, respectively. This finding suggested that the combination of these biomarkers performed much better than CA125 alone. Hyp-Leu and Gly-Phe-Trp showed significantly improved performances in the log-rank tests and Kaplan-Meier curves demonstrating their prognostic potential. All SP-biomarkers proved to have excellent stabilities at room temperature. Correlation network analysis implied latent conversions among amino acids, dipeptides and tripeptides during EOC. In conclusion, the selected SPs in combination with CA125 show profound promise for discriminating EOCs from BOTs and for predicting the progression after surgery, which provides invaluable information for clinicians in the precision diagnosis and treatment of EOC. This article is protected by copyright. All rights reserved.

show abstract

Differential Distribution of Type IV Collagen .ALPHA.1 to .ALPHA.6 Chains Suggests Distinct Molecular Interaction between the Epithelial and Mesenchymal Components of Benign Odontogenic Tumors

Cited by 6 publications

References 26 publications

Heparanase and its related molecules in odontogenic tumors

Heparanase and its related molecules in odontogenic tumors

Immunohistochemical expression of Type IV Collagen and Autocrine Motility Factor Receptor in Odontogenic Tumours

Selection of small plasma peptides for the auxiliary diagnosis and prognosis of epithelial ovarian cancer by using UPLC/MS‐based nontargeted and targeted analyses

Contact Info

Product

Resources

About