2021
DOI: 10.1038/s41598-021-84605-y
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Differential effect of anesthetics on mucociliary clearance in vivo in mice

Abstract: Respiratory mucociliary clearance (MCC) is a key defense mechanism that functions to entrap and transport inhaled pollutants, particulates, and pathogens away from the lungs. Previous work has identified a number of anesthetics to have cilia depressive effects in vitro. Wild-type C57BL/6 J mice received intra-tracheal installation of 99mTc-Sulfur colloid, and were imaged using a dual-modality SPECT/CT system at 0 and 6 h to measure baseline MCC (n = 8). Mice were challenged for one hour with inhalational 1.5% … Show more

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Cited by 12 publications
(8 citation statements)
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“…atropine) [ 67 , 68 ] or inhibit ciliary movement (e.g. local anesthetics such as ketamine/xylazine and fentanyl) [ 69 ], increasing the potential for adverse effects.…”
Section: Challenges Of Intranasal Deliverymentioning
confidence: 99%
“…atropine) [ 67 , 68 ] or inhibit ciliary movement (e.g. local anesthetics such as ketamine/xylazine and fentanyl) [ 69 ], increasing the potential for adverse effects.…”
Section: Challenges Of Intranasal Deliverymentioning
confidence: 99%
“…As reported, intraperitoneal injection of pentobarbital sodium/ketamine [ 70 ], urethane/alpha-chloralose [ 71 ], and ketamine/xylazine [ 72 ], as well as inhaled isoflurane have been applied as anesthetic agents in this surgical procedure. The combination of pentobarbital/Ketamine/xylazine decreases the tracheal mucociliary clearance [ 73 ]. However, isoflurane, propofol, or fentanyl/dexmedetomidine/midazolam do not seem to change the tracheal mucociliary clearance values [ 73 ].…”
Section: Maintenancementioning
confidence: 99%
“…The combination of pentobarbital/Ketamine/xylazine decreases the tracheal mucociliary clearance [ 73 ]. However, isoflurane, propofol, or fentanyl/dexmedetomidine/midazolam do not seem to change the tracheal mucociliary clearance values [ 73 ]. Opioid analgesics such as buprenorphine should be used as intra-operative analgesics.…”
Section: Maintenancementioning
confidence: 99%
“…We define direct effects as those resulting directly from the mechanical ventilation circuit (including epithelial damage from endotracheal tube and cuff, anesthetics, lack of humidification, direct cough impairment) vs. indirect effects resulting from comorbid critical illness (inflammation, immobility, atelectasis) ( Sackner et al, 1975a ; Konrad et al, 1994 ). Anesthetic medications, specifically dexmedetomidine and ketamine, have been shown in in vitro models to directly decrease mucociliary clearance ( Feldman et al, 2021 ). High FiO2 is known to decrease tracheal mucus velocity, likely through impaired ciliary function ( Sackner et al, 1975b ).…”
Section: Airway Clearance Deficits In Critically Ill Patientsmentioning
confidence: 99%