Differential effect of buspirone and diazepam on negative contrast in one-way avoidance learning

Torres, Carmen; Morales, Alberto; Cândido, Antônio; Maldonado, Antonio

doi:10.1016/0014-2999(95)00210-c

Cited by 10 publications

(6 citation statements)

References 42 publications

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“…The present result, that pretraining systemic injection of buspirone impaired retention of an inhibitory avoidance response, is consistent with previous ones that buspirone impeded acquisition of an avoidance task in rats (Torres et al . 1995) and a conditioned emotional response in mice (Quartermain et al .…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to the extensive evidence showing an impairing effect of the anxiolytic benzodiazepines on learning and memory (Curran, 1990), not many studies have examined the effect of buspirone on acquisition and/or retention in aversive learning tasks, and the results have been somewhat inconsistent (Korneyev, 1997). Pretraining injections of buspirone have been reported to retard acquisition of avoidance or escape behaviour in some studies (McNaughton & Morris, 1992;Torres et al, 1995) but not in others (Rowan et al, 1990). Likewise, results concerning the effects of buspirone given before testing on memory expression in different types of tasks are not consistent Rowan et al, 1990;Bass et al, 1992;Quartermain et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

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Pre‐ or post‐training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5‐HT_1A receptors

Liang

1999

Eur J of Neuroscience

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The present study investigated the effect of buspirone on memory formation in an aversive learning task. Male Wistar rats were trained on the inhibitory avoidance task and tested for retention 1 day after training. They received peripheral or intra-amygdala administration of buspirone or other 5-HT1A drugs either before or after training. Results indicated that pretraining systemic injections of buspirone caused a dose-dependent retention deficit; 5. 0 mg/kg had a marked effect and 1.0 mg/kg had no effect. Post-training injections of the drug caused a time-dependent retention deficit, which was not due to a state-dependent effect on retrieval. When training in the inhibitory avoidance task was divided into a context-training phase and a shock-training phase, buspirone impaired retention only when administered in the shock-training phase, suggesting that the drug influenced memory processing of affective events. Further results indicated that post-training intra-amygdala infusion of buspirone or the 5-HT1A agonist 8-hydroxy-di-n-propylaminotetralin (8-OH-DPAT) caused a time-dependent and dose-dependent retention deficit. Post-training intra-amygdala infusion of the 5-HT1A antagonist WAY100635 (N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)-N-(2-pyridyl) cyclohexane carboxamine maleate) attenuated the memory-impairing effects of buspirone. These findings suggest that buspirone may modulate memory storage processes in the inhibitory avoidance task through an action on amygdaloid 5-HT1A receptors.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pre‐ or post‐training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5‐HT_1A receptors

Liang

1999

Eur J of Neuroscience

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“…For example, pretrial treatment with the serotoninergic drugs buspirone and gepirone produced no detectable effects on the cSNC situation (Flaherty et al, 1990a). Buspirone also failed to reduce SNC in the one-way active avoidance situation (Torres et al, 1995). These two papers also showed that both cSNC and SNC in one-way avoidance were reduced by treatment with benzodiazepine anxiolytics.…”

Section: Anxiolytics and Antidepressantsmentioning

confidence: 93%

Behavioral neuroscience of psychological pain

Papini

Fuchs

Torres

2015

Neuroscience & Biobehavioral Reviews

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“…In addition, administration of 8-OH-DPAT following the acquisition session (2hr) hindered consolidation of the new learning [167]. Interestingly, pretreatment with a 5-HT 1A R agonist impaired retrieval of spatial and contextual cues in passive avoidance paradigms and the Morris water maze [6,49,51,150,188,188,218,221,253,284,311], an effect linked to stimulation of the postsynaptic, as opposed to the presynaptic, 5-HT 1A R [49,241]. Contradictorily, one study reported an improvement in memory retrieval after pretreatment with a 5-HT 1A R antagonist in the object recognition task [252], however, this observation has not been replicated in other paradigms of memory retrieval [210,212].…”

Section: Serotonin Mechanisms In Memory Formationmentioning

confidence: 99%

Serotonergic mechanisms in addiction-related memories

Dhonnchadha

Cunningham²

2008

Behavioural Brain Research

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Drug-associated memories are a hallmark of addiction and a contributing factor in the continued use and relapse to drugs of abuse. Repeated association of drugs of abuse with conditioned stimuli leads to long-lasting behavioral responses that reflect reward-controlled learning and participate in the establishment of addiction. A greater understanding of the mechanisms underlying the formation and retrieval of drug-associated memories may shed light on potential therapeutic approaches to effectively intervene with drug use-associated memory. There is evidence to support the involvement of serotonin (5-HT) neurotransmission in learning and memory formation through the families of the 5-HT1 receptor (5-HT1R) and 5-HT2R which have also been shown to play a modulatory role in the behavioral effects induced by many psychostimulants. While there is a paucity of studies examining the effects of selective 5-HT1AR ligands, the available dataset suggests that 5-HT1BR agonists may inhibit retrieval of cocaine-associated memories. The 5-HT2AR and 5-HT2CR appear to be integral in the strong conditioned associations made between cocaine and environmental cues with 5-HT2AR antagonists and 5-HT2CR agonists possessing potency in blocking retrieval of cocaine-associated memories following cocaine self-administration procedures. The complex anatomical connectivity between 5-HT neurons and other neuronal phenotypes in limbic-corticostriatal brain structures, the heterogeneity of 5-HT receptors (5-HTXR) and the conflicting results of behavioral experiments which employ non-specific 5-HTXR ligands contribute to the complexity of interpreting the involvement of 5-HT systems in addictive-related memory processes. This review briefly traces the history of 5-HT involvement in retrieval of drug-cue associations and future targets of serotonergic manipulation that may reduce the impact that drug cues have on addictive behavior and relapse.

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Differential effect of buspirone and diazepam on negative contrast in one-way avoidance learning

Cited by 10 publications

References 42 publications

Pre‐ or post‐training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5‐HT_1A receptors

Pre‐ or post‐training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5‐HT_1A receptors

Behavioral neuroscience of psychological pain

Serotonergic mechanisms in addiction-related memories

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Differential effect of buspirone and diazepam on negative contrast in one-way avoidance learning

Cited by 10 publications

References 42 publications

Pre‐ or post‐training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5‐HT1A receptors

Pre‐ or post‐training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5‐HT1A receptors

Behavioral neuroscience of psychological pain

Serotonergic mechanisms in addiction-related memories

Contact Info

Product

Resources

About

Pre‐ or post‐training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5‐HT_1A receptors

Pre‐ or post‐training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5‐HT_1A receptors