Differential Effect of Dietary Protein Type on the B-Cell and T-Cell Immune Responses in Mice

Bounous, G; Kongshavn, Patricia A. L.

doi:10.1093/jn/115.11.1403

Cited by 56 publications

(29 citation statements)

References 12 publications

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“…A further study (Wong & Watson, 1995) has provided additional evidence that dietary WPC can enhance antibody responses to systemically-administered antigen in mice, possibly via a mechanism of enhanced lymphocyte activation and cellular function Bounous & Kongshavn, 1985;Wong et al, 1996). Thus, the common paradigm appears to be that some WPCs can potentiate immune activity, in particular B cell production of antibodies in response to systemic immunization Wong & Watson, 1995).…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Mucosal Antibody Responses by Dietary Whey Protein Concentrate

Low¹,

Rutherfurd²,

Cross³

et al. 2001

Food and Agricultural Immunology

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The effect of dietary bovine whey protein concentrate (WPC) on gut mucosal antibody responses to orally-administered antigens was investigated in BALB/c mice. Test mice were fed a diet containing 20% (w /w ) total protein of a novel WPC (ALACEN 472) for 12 weeks.Test and control (chow-fed) mice were immunized orally with cholera toxin (CT) and ovalbumin (OVA) at different times throughout the dietary regime, and gut mucosal antibody responses were assessed at the end of the experiment. Both groups of mice produced mucosal antibodies against CT and OVA, although responses were significantly higher among WPCfed mice, regardless of the time-point at which immunizations were administered throughout the study. WPC had no significant effect on blood lymphocyte phenotype expression or splenic T or B cell mitogenesis, suggesting that the immunomodulatory action was not due to systemic lymphocyte activation. This study confirms previous reports that dietary WPC can potentiate humoral immunity in mice, and provides the first evidence that WPC can enhance mucosal antibody responses to orally-administered antigens.

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Section: Introductionmentioning

confidence: 99%

Enhancement of Mucosal Antibody Responses by Dietary Whey Protein Concentrate

Low¹,

Rutherfurd²,

Cross³

et al. 2001

Food and Agricultural Immunology

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“…By increasing ␣-lactalbumin, a major human milk whey protein, and decreasing the content of ␤-lactoglobulin, a major bovine whey protein, which is absent from human milk, it is possible to reduce the total protein content in a formula and achieve a plasma amino acid profile in FF infants more similar to that of BF infants (7). Besides having a well-balanced amino acid composition, ␣-lactalbumin has antimicrobial and also other biological effects (8,9). Caseinoglycomacropeptide (CGMP) is cleaved off from -casein by pepsin digestion in the stomach and has also been shown to have antimicrobial, immunomodulatory, and prebiotic effects (10 -13), including promoting growth of bifidobacteria (14).…”

mentioning

confidence: 99%

Formula Feeding Skews Immune Cell Composition toward Adaptive Immunity Compared to Breastfeeding

Andersson¹,

Hammarström

Lönnerdal

et al. 2009

The Journal of Immunology

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The ontogeny of the immune system and the effect thereon by type of infant feeding is incompletely understood. We analyzed frequencies and composition of immune cells in blood of breastfed (BF) and formula-fed (FF) infants at 1.5, 4, and 6 mo of age. Three formulas with the same protein concentration but with varying levels of α-lactalbumin and caseinoglycomacropeptide were compared. Twenty-nine exclusively BF infants served as reference, and 17 infants in each formula group completed the study. Whole blood and PBMCs were analyzed by flow cytometry and immunoflow cytometry, respectively. Leukocyte count of BF infants increased with time due to increased frequency of neutrophils. Lymphocyte count was high at 1.5 mo and was unchanged over time, as were the relative proportions of CD4+ αβT cells, CD8+ αβT cells, B cells, NK cells, and γδT cells. Most CD45R0+CD3+ cells were HLA-DR− and hence memory cells. Compared with breastfeeding, formula feeding resulted in a significant decrease in proportion of NK cells, but a significant increase in naive CD4+ αβT cells and an elevated CD4-to-CD8 ratio, that is, 3.3 in the combined FF groups compared with 2.6 in the BF group. No significant differences were found between the three groups of FF infants. In conclusion, blood cells of lymphoid lineage did not change significantly in frequencies or composition from 1.5 to 6 mo of age in BF infants. In contrast, FF infants displayed an ongoing maturation of adaptive immunity cells and a delayed recruitment of innate immunity cells as compared with BF infants.

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“…In 1985 Bounous and Kongshavn were among the first researchers to demonstrate an immunoenhancing effect of β-lactoglobulin [5]. They showed that the whey proteins (principally β-lactoglobulin and BSA) increase the number of antibody-forming cells in the spleen of mice immunized with trinitrophenylated ficoll.…”

mentioning

confidence: 99%

Whey proteins and peptides: beneficial effects on immune health

Beaulieu¹,

Dupont²,

Lemieux³

2006

Therapy

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A 65-year-old male with liver metastases after lung cancer resection was treated with five courses of chemotherapy consisting of gemcitabine (GEM) 1,000 mg/m2 (day 1, 8, every 4 weeks) plus carboplatin (CBDCA) AUC 6 (day 1, every 4 weeks). A partial response (PR) was achieved, his symptoms abated and his quality of life(QOL) improved. Although bone marrow suppression was observed as a side effect, it was within the tolerable range and did not interfere with therapy. This approach may be worth considering as a first-line anti-cancer chemotherapy for recurrence lung cancer.

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Differential Effect of Dietary Protein Type on the B-Cell and T-Cell Immune Responses in Mice

Cited by 56 publications

References 12 publications

Enhancement of Mucosal Antibody Responses by Dietary Whey Protein Concentrate

Enhancement of Mucosal Antibody Responses by Dietary Whey Protein Concentrate

Formula Feeding Skews Immune Cell Composition toward Adaptive Immunity Compared to Breastfeeding

Whey proteins and peptides: beneficial effects on immune health

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