Differential effect of environment enrichment and social isolation on depressive-like behavior, spontaneous activity and serotonin and norepinephrine concentration in prefrontal cortex and ventral striatum

Brenes, Juan C.; Rodríguez, Odir; Fornaguera, Jaime

doi:10.1016/j.pbb.2007.11.004

Cited by 226 publications

(183 citation statements)

References 46 publications

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“…Human neuroimaging studies also demonstrate that disturbed regulation between regions involved in reward processing occur via the serotonin transporter (Hahn et al, 2014). Preclinical studies further show that anxiety and depressive-like behavior associate with lower levels of serotonin and norepinephrine in the striatum (Brenes et al, 2008) where serotonergic and adrenergic systems are targets of commonly prescribed antidepressants. Though it is possible that changes in striatal morphometry may be influenced by anesthesia rather than by treatment-related effects, observations of change in responders vs nonresponders makes this less likely.…”

Section: Discussionmentioning

confidence: 95%

Effect of Electroconvulsive Therapy on Striatal Morphometry in Major Depressive Disorder

Wade

Joshi

Njau

et al. 2016

Neuropsychopharmacol

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Patients with major depression show reductions in striatal and paleostriatal volumes. The functional integrity and connectivity of these regions are also shown to change with antidepressant response. Electroconvulsive therapy (ECT) is a robust and rapidly acting treatment for severe depression. However, whether morphological changes in the dorsal and ventral striatum/pallidum relate to or predict therapeutic response to ECT is unknown. Using structural MRI, we assessed cross-sectional effects of diagnosis and longitudinal effects of ECT for volume and surface-based shape metrics of the caudate, putamen, pallidum, and nucleus accumbens in 53 depressed patients (mean age: 44.1 years, 13.8 SD; 52% female) and 33 healthy controls (mean age: 39.3 years, 12.4 SD; 57% female). Patients were assessed before ECT, after their second ECT, and after completing an ECT treatment index. Controls were evaluated at two time points. Support vector machines determined whether morphometric measures at baseline predicted ECT-related clinical response. Patients showed smaller baseline accumbens and pallidal volumes than controls (Po0.05). Increases in left putamen volume (Po0.03) occurred with ECT. Global increases in accumbens volume and local changes in pallidum and caudate volume occurred in patients defined as treatment responders. Morphometric changes were absent across time in controls. Baseline volume and shape metrics predicted overall response to ECT with up to 89% accuracy. Results support that ECT elicits structural plasticity in the dorsal and ventral striatum/pallidum. The morphometry of these structures, forming key components of limbic-cortical-striatal-pallidal-thalamic circuitry involved in mood and emotional regulation, may determine patients likely to benefit from treatment.

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Section: Discussionmentioning

confidence: 95%

Effect of Electroconvulsive Therapy on Striatal Morphometry in Major Depressive Disorder

Wade

Joshi

Njau

et al. 2016

Neuropsychopharmacol

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“…Subsequent studies confirmed and extended this initial observation to other neurotransmitter systems, showing that EE increases noradrenaline concentration and strengthens the b-adrenoceptor signalling pathway in the cerebral cortex, cerebellum and brainstem, 27,103 and augments mRNA expression levels of serotonin 1A receptor and serotonin (5-HT) concentration in the cerebral cortex and hippocampus. 25,104,105 Interestingly, in vitro studies have repeatedly reported that 5-HT, acetylcholine, dopamine and, to a lesser extent, noradrenaline, suppress inhibition in several brain regions, including the visual cortex, possibly through a presynaptic mechanism mediated, respectively, by 5-HT 1/2 , muscarinic D1 and the a-adrenergic receptor families. [106][107][108][109][110][111][112][113] Moreover, very recently, a modification of visual cortex pyramidal neuron responses to input signals depending on the behavioural state has been observed, related to a bidirectional modulation of somatic inhibition.…”

Section: Impact Of Ee On the Brain L Baroncelli Et Almentioning

confidence: 99%

Nurturing brain plasticity: impact of environmental enrichment

et al. 2009

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Environmental enrichment (EE) is known to profoundly affect the central nervous system (CNS) at the functional, anatomical and molecular level, both during the critical period and during adulthood. Recent studies focusing on the visual system have shown that these effects are associated with the recruitment of previously unsuspected neural plasticity processes. At early stages of brain development, EE triggers a marked acceleration in the maturation of the visual system, with maternal behaviour acting as a fundamental mediator of the enriched experience in both the foetus and the newborn. In adult brain, EE enhances plasticity in the cerebral cortex, allowing the recovery of visual functions in amblyopic animals. The molecular substrate of the effects of EE on brain plasticity is multi-factorial, with reduced intracerebral inhibition, enhanced neurotrophin expression and epigenetic changes at the level of chromatin structure. These findings shed new light on the potential of EE as a non-invasive strategy to ameliorate deficits in the development of the CNS and to treat neurological disorders.

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“…Notably, this form of environmental modification has been demonstrated to ameliorate behavioral abnormalities in rodent models of psychiatric disorders, including schizophrenia-like behaviors (Brenes et al, 2008;Chourbaji et al, 2008;McOmish et al, 2008). EE has been shown to upregulate expression of NMDAR subunits, as well as other components of the glutamatergic system (Tang et al, 2001;Bredy et al, 2003;Naka et al, 2005;Andin et al, 2007;Mora et al, 2007) suggesting that disruptions resulting from NMDAR dysfunction could be ameliorated following exposure to enriched housing.…”

Section: Introductionmentioning

confidence: 99%

Environmental Enrichment Ameliorates Behavioral Impairments Modeling Schizophrenia in Mice Lacking Metabotropic Glutamate Receptor 5

Burrows

McOmish

Buret

et al. 2015

Neuropsychopharmacol

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Schizophrenia arises from a complex interplay between genetic and environmental factors. Abnormalities in glutamatergic signaling have been proposed to underlie the emergence of symptoms, in light of various lines of evidence, including the psychotomimetic effects of NMDA receptor antagonists. Metabotropic glutamate receptor 5 (mGlu5) has also been implicated in the disorder, and has been shown to physically interact with NMDA receptors. To clarify the role of mGlu5-dependent behavioral expression by environmental factors, we assessed mGlu5 knockout (KO) mice after exposure to environmental enrichment (EE) or reared under standard conditions. The mGlu5 KO mice showed reduced prepulse inhibition (PPI), long-term memory deficits, and spontaneous locomotor hyperactivity, which were all attenuated by EE. Examining the cellular impact of genetic and environmental manipulation, we show that EE significantly increased pyramidal cell dendritic branching and BDNF protein levels in the hippocampus of wild-type mice; however, mGlu5 KO mice were resistant to these alterations, suggesting that mGlu5 is critical to these responses. A selective effect of EE on the behavioral response to the NMDA receptor antagonist MK-801 in mGlu5 KO mice was seen. MK-801-induced hyperlocomotion was further potentiated in enriched mGlu5 KO mice and treatment with MK-801 reinstated PPI disruption in EE mGlu5 KO mice only, a response that is absent under standard housing conditions. Together, these results demonstrate an important role for mGlu5 in environmental modulation of schizophreniarelated behavioral impairments. Furthermore, this role of the mGlu5 receptor is mediated by interaction with NMDA receptor function, which may inform development of novel therapeutics.

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Differential effect of environment enrichment and social isolation on depressive-like behavior, spontaneous activity and serotonin and norepinephrine concentration in prefrontal cortex and ventral striatum

Cited by 226 publications

References 46 publications

Effect of Electroconvulsive Therapy on Striatal Morphometry in Major Depressive Disorder

Effect of Electroconvulsive Therapy on Striatal Morphometry in Major Depressive Disorder

Nurturing brain plasticity: impact of environmental enrichment

Environmental Enrichment Ameliorates Behavioral Impairments Modeling Schizophrenia in Mice Lacking Metabotropic Glutamate Receptor 5

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