1983
DOI: 10.1111/j.1365-2125.1983.tb02256.x
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Differential effect of isoniazid on triazolam oxidation and oxazepam conjugation.

Abstract: Healthy volunteers received a single dose of triazolam (0.5 mg) or oxazepam (30 mg) on two occasions, once in the control state and again during coadministration of isoniazid (INH) base, 180 mg day. INH coadministration prolonged triazolam half-life (3.3 vs 2.5 h, P < 0.05) and increased total area under the curve (38.6 vs 26.5 ng ml-' h, P < 0.01) consistent with a reduction of apparent oral clearance (3.9 vs 6.8 ml minm 'kg-', 0.05 < P < 0.1). INH coadministration had no influence on the kinetics of oxazepam… Show more

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Cited by 38 publications
(10 citation statements)
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“…Although the impact of clofazimine on UTG is not well established, a DTG area under the AUC ratio AUCR (AUCinhibitor/AUCcontrol) of 3.0 was reported, comparable to those reported with lopinavir and other strongly inhibited antiviral agents during co-administration with clofazimine (Sangana et al, 2018). Similarly AUCRs of 2.25, 2.93 and 5.59 were reported for the anti-TB drugs bedaquiline, clarithromycin and delamanid, respectively (Ochs et al, 1983). Therefore, the inductive effect of MDR-TB agents may affect other drugs, including other anti-TB agents.…”
Section: Art Drug Interactions With Cellular Metabolic Pathwayssupporting
confidence: 62%
“…Although the impact of clofazimine on UTG is not well established, a DTG area under the AUC ratio AUCR (AUCinhibitor/AUCcontrol) of 3.0 was reported, comparable to those reported with lopinavir and other strongly inhibited antiviral agents during co-administration with clofazimine (Sangana et al, 2018). Similarly AUCRs of 2.25, 2.93 and 5.59 were reported for the anti-TB drugs bedaquiline, clarithromycin and delamanid, respectively (Ochs et al, 1983). Therefore, the inductive effect of MDR-TB agents may affect other drugs, including other anti-TB agents.…”
Section: Art Drug Interactions With Cellular Metabolic Pathwayssupporting
confidence: 62%
“…In humans, INH has been found to decrease the clearance of several drugs, including phenytoin (see, e.g., references 3, 24, and 30), carbamazepine (54,58,59), diazepam (36), triazolam (37), vincristine (7), primidone (48), and acetaminophen (10,35), sufficiently to require a reduction of the dose or discontinuation of INH. Upon consideration of the primary metabolic pathways of the drugs affected and the enzymes catalyzing them, many of these drug-drug interactions appear to be attributable to pharmacokinetic changes that can be understood in terms of alterations of multiple hepatic drug metabolic pathways catalyzed by the cytochrome P450 (CYP450) system (2).…”
mentioning
confidence: 99%
“…Studying pharmacokinetic and pharmacodynamic interactions of diazepam and the beta-blocker metoprolol, Klotz and Reimann (1984) found only minor and clinically irrelevant changes in drug metbolism and drug response. Differential effects of isoniazid on triazolam oxidation and oxazepam conjunction were observed by Ochs et al (1983). They noted that isoniazid (INH) base coadministration had no influence on the kinetics of oxazepam.…”
Section: Factors Influencing the Pharmacokinetics Of Bzdmentioning
confidence: 99%