Differential effect of lentil feeding on proteosynthesis rates in the large intestine, liver and muscle of rats1

Combe, Etiennette; Pirman, Tatjana; Stekar, Jasna; Mirand, Marie-Louise Houliera et Philippe Patureau

doi:10.1016/j.jnutbio.2003.08.006

Cited by 16 publications

(25 citation statements)

References 28 publications

(33 reference statements)

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“…Similar effects on muscle mass and protein synthesis rates were already described with Vicia faba [33] , kidney beans [34] , peas [35] or cooked lentils [12] . However, the effect was abolished by heat treatment [34,35] and amino acid supplementation [35] .…”

Section: Discussionsupporting

confidence: 76%

“…However, the effect was abolished by heat treatment [34,35] and amino acid supplementation [35] . Consequently, the legume effect observed in the present experiment and in a previous experiment with cooked lentils [12] would result from other factors than heat-labile antinutritional factors and/or primary amino acid defi ciency. Indeed the legume diets were supplemented in the limiting sulfur amino acids and tryptophan with the result that their calculated amino acid contents ( table 1 ) were higher than the amounts needed to meet rat requirements [36] .…”

Section: Discussionsupporting

confidence: 39%

“…It is the fi rst time that an increase of protein synthesis rates was reported in small intestine with cooked legumes although it was already observed in large intestine of rats fed a cooked lentil diet [12] . It is consistent with the increase in intestinal protein content, in endogenous protein secretion and in enterocyte renewal [8] and maturational changes [6,7,21] .…”

Section: Discussionmentioning

confidence: 99%

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Differential Effects of Cooked Beans and Cooked Lentils on Protein Metabolism in Intestine and Muscle in Growing Rats

Pirman

Combe²,

Ribeyre³

et al. 2006

Ann Nutr Metab

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Aims: The effect of diets based on cooked beans or lentils on protein metabolism in intestines and muscles was studied in rats. Method: The cooked seeds were used as the unique protein source in balanced diets (containing 229 and 190 g of crude protein per kg dry matter) fed to young growing rats for 20 days. Their effects were compared with those of the control casein diet in pair-fed rats. Protein synthesis rates in small and large intestines and in gastrocnemius and soleus muscles were determined in vivo, in a fed state, by the flooding dose method, using ¹³C-valine. Results: In the small and large intestine tissues of the legume fed groups, protein, RNA relative masses (mg·100 g BM^–1) and protein synthesis rates (FSR and ASR) were higher than in the control rats (p < 0.05). In gastrocnemius and soleus muscles,protein and RNA contents (in mg) and protein synthesis rates were significantly (p < 0.05) lower in the legume-fed groups than in the control rats. Conclusion: The chronic intake of cooked legumes increased protein synthesis rates in intestinal tissues and decreased them in muscles. This effect was greater for beans than for lentils in the large intestine and in gastrocnemius muscle.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionsupporting

confidence: 39%

Section: Discussionmentioning

confidence: 99%

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Differential Effects of Cooked Beans and Cooked Lentils on Protein Metabolism in Intestine and Muscle in Growing Rats

Pirman

Combe²,

Ribeyre³

et al. 2006

Ann Nutr Metab

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“…One of the potential explanations for the low efficacy of intramuscularly injected DNA vaccines to adult animals and humans appears to be related to the low level of protein synthesis in skeletal muscles when compared to other tissues. For example, in the growing 3–6 week old rats, the absolute synthetic rate (mg of protein/day/100 g body weight) is 15.9 ± 3.2 in the muscle, but 695 ± 209 in the liver (Combe et al, 2004). When DNA is targeted to the liver by hydrodynamic intravenous application, high and long-lasting humoral and cellular immune responses are induced, which exceed such responses induced by the intramuscular application of equal doses of DNA by several orders of magnitude (Raska et al, 2008).…”

Section: Induction Of Humoral Responses In External Secretions Of mentioning

confidence: 99%

Antibody-mediated protection and the mucosal immune system of the genital tract: relevance to vaccine design

Městecký

Raška

Novák

et al. 2010

Journal of Reproductive Immunology

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Mucosal tissues of the genital tracts and the distal intestinal tract are portals of entry for infectious agents of sexually transmitted diseases, including HIV-1. Although the genital and intestinal tracts share a common embryologic origin and remain in anatomical proximity, these two sites display remarkably different immunologic features, including the levels, isotypes and molecular forms of immunoglobulins, and magnitudes and qualities of humoral and cellular immune responses. Thus, viral and bacterial infections of the genital tract or intravaginal immunizations induce, in the absence of mucosal adjuvants, minimal immune responses. Consequently, to induce relevant immune responses in the genital tract, alternative immunization routes have been explored, including systemic, intranasal, oral, or rectal immunization and their combinations. In limited studies performed in animals, systemic immunization with a subsequent mucosal (intranasal) immunization proved to be effective in the induction of humoral immune responses in genital tract secretions. The approaches have been explored to a limited extent in humans.

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“…[5] Lentils are being considered as one of the most beneficial legumes for health. [6] Earlier reports suggested lentils possess anti-diabetic, anti-cancer, anti-hyperlipidemic, and excellent free radical scavenging activity. [7] They are used in traditional medicine as blood purifier, diuretic, and antifungal.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Adikay

2016

IJGP

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Objectives: The main objective of current study was to determine the phytoremedial effect of ethanol extract of seeds of Lens culinaris against doxorubicin-induced nephrotoxicity using biochemical and histopathological approaches. Materials and Methods: Ethanol extract of seeds of L. culinaris was prepared by hot extraction method, and preliminary phytochemical studies had been carried out. Nephrotoxicity was induced in male Wistar rats by single intraperitoneal administration of doxorubicin (15 mg/kg b.wt.). Nephroprotector effect of the extract was screened at two different dose levels, i.e. 200 and 400 mg/kg b.wt. by oral administration for 8 days. Nephrotoxicity was assessed by determining blood urea nitrogen (BUN), serum creatinine (SC), serum total protein (S TP ), urinary total protein (U TP ), and urinary creatinine (U Cr ). Renal oxidative stress markers superoxide dismutase (SOD), catalase (CAT), lipid peroxidation (LPO), and glutathione reduced (GSH) were also measured in kidney tissue. Results: The treatment with ethanol extract significantly decreased the levels of BUN, SC, S TP , U TP and LPO which were elevated by doxorubicin induction. In addition, extract also ameliorated the levels of U Cr , SOD, CAT and GSH in dose-dependent manner. Histopathological studies had also substantiated the biochemical parameters. Conclusion: The results suggest that ethanol extract of seeds of L. culinaris possess potent phytoremedial effect against doxorubicin-induced nephrotoxicity.

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Differential effect of lentil feeding on proteosynthesis rates in the large intestine, liver and muscle of rats1

Cited by 16 publications

References 28 publications

Differential Effects of Cooked Beans and Cooked Lentils on Protein Metabolism in Intestine and Muscle in Growing Rats

Differential Effects of Cooked Beans and Cooked Lentils on Protein Metabolism in Intestine and Muscle in Growing Rats

Antibody-mediated protection and the mucosal immune system of the genital tract: relevance to vaccine design

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