Differential effect of lithium on 5-HT1 receptor-linked system in regions of rat brain

Effect of lithium administration on collagen and breaking pressure of the rat thoracic descending aorta

“…Their average serum lithium level was 0.65 ± 0.08 mmol/L at the end of the 30-day period. This experimental period was selected for study because although the efficacy of lithium on individuals as a mood stabilizer is associated with prolonged treatment, in studies concerning lithium effects in rat tissues the usual duration of treatment is between 15 to 30 days [21,35]. Animals were treated with lithium intraperitoneally instead of per os because the latter treatment evokes more pronounced renal problems to experimental species with compared to those after other routes of administration [36].…”

Collagenous Tissues upon Lithium Treatment: A Quantitative Ultrastructural Study

“…Lithium alters levels of key membrane phospholipids and appears to affect the balance between inhibitory and excitatory amino acids in rat brain [53,54]. Other data point to a link between the therapeutic efficacy of lithium and the response of 5-hydroxytryptamine-1 [5-HT1] [55] and dopamine D2 [56] receptors. In a rat model of depression, lithium treatment altered the brain concentrations of neurotrophic factors [57].…”

“…Animals were sacrificed 1 day, 2, 6, and 12 months after the end of a 30 consecutive days experimental period. No longer-term lithium treatment was investigated, as in studies concerning lithium effects in rat brain, the usual duration of treatment is between 15-30 days [47,49,53,55]. In all cases investigated, severe structural abnormalities in collagen fibrils are found [26].…”

Efeitos comportamentais da lesão eletrolítica da região do núcleo mediano da rafe como modelo experimental de mania no rato e no camundongo

“…Além da ação do lítio sobre os sistemas noradrenérgico e dopaminérgico, as propriedades antidepressivas do lítio somadas a dados de pesquisas (Bourin et al, 1996;Scheuch et al, 2010;Subhash et al, 1999) …”

“…Esta proposição é consistente com achados clínicos de alterações volumétricas e funcionais dos neurônios da rafe em pacientes acometidos pelo transtorno bipolar (Matthews & Harrison, 2012;Sullivan et al, 2009 Sabe-se também que o lítio exerce diversas ações bioquímicas relacionadas à liberação cálcio-dependente de noradrenalina e dopamina, ao bloqueio de síntese de fosfatidilinositol e modificação de respostas mediadas pelo sistema adenilatociclase e AMPc (Gorenstein & Scavone, 1999). Adicionalmente, propriedades antidepressivas do lítio somadas a dados de pesquisas (Bourin, Hascoet, Colombel, Redrobe, & Baker, 1996;Scheuch et al, 2010;Subhash, Vinod, & Srinivas, 1999) fornecem indícios da relevância do sistema serotoninérgico central na eficácia desta droga.…”