Differential effect of metformin and/or glyburide on apelin serum levels in patients with type 2 diabetes mellitus: Concepts and clinical practice

Al-Kuraishy, Hayder M; Al-Gareeb, Ali I; Waheed, Huda Jaber; Al-Maiahy, Thabat J

doi:10.4103/japtr.japtr_273_18

Cited by 41 publications

(27 citation statements)

References 32 publications

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“…These genes similarly contain sequences that encode for the high mobility group-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes [14].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Sex-Determining Region Y-Box 2 (Sox2) in Prostate Cancer

Mohasen¹,

Ahmed²

2019

Asian J Pharm Clin Res

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Objectives: The objectives of this study were to evaluate the expression of sex-determining region-Y BOX 2 (SOX2) markers and their association with clinicopathological parameters. Methods: A cross-sectional study was carried out to involve 90 specimens from patients diagnosed with prostatic cancer (PC) and benign prostatic hypertrophy (BPH) compared with positive control (human bronchial tissue for SOX2 marker) with each run. Results: The highest proportion of specimens of PC was graded ≤7 by Gleason grading system (53.3%). There were significant associations (p<0.05) between all this cancer stem cell marker results and prevalence of PC. Positive SOX2 marker result was significantly associated with bad prognostic sign (81.3%, p=0.001). This marker was highly sensitive (100%) specificity (82.4%), with high accuracy (90%). Conclusion: There was a significant expression of SOX2 in prostate adenocarcinomas. SOX2 can be considered as a key regulator of tumor progression, aggressive behavior, and metastasis. Furthermore, it is a reliable marker for the early diagnosis and the designed chemotherapy of prostate adenocarcinomas.

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Section: Discussionmentioning

confidence: 99%

Prognostic Value of Sex-Determining Region Y-Box 2 (Sox2) in Prostate Cancer

Mohasen¹,

Ahmed²

2019

Asian J Pharm Clin Res

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“…Women with GDM are presented with polydipsia, fatigue, vomiting, recurrent urinary tract infections, and blurred vision. High placental hormones and inflammatory cytokines increase the development of IR and pancreatic cell adaptation [ 13 , 14 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Plasminogen activator inhibitor 1 and gestational diabetes: the causal relationship

Batiha

Al-Kuraishy

Al-Maiahy

et al. 2022

Diabetol Metab Syndr

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Plasminogen activator inhibitor 1 (PAI-1) also known as serpin E1 or endothelial plasminogen activator inhibitor, is produced from endothelial cells and adipose tissue. PAI-1 inhibits tissue plasminogen activator (tPA) and urokinase (uPA) preventing activation of plasminogen and fibrinolysis. Gestational diabetes mellitus (GDM) is defined as glucose intolerance and hyperglycemia during pregnancy. The underlying mechanism of GDM is due to the reduction of insulin secretion or the development of insulin resistance (IR). Normal PAI-1 is a crucial mediator for maintaining pregnancy, though aberrantly high PAI-1 promotes inflammation and thrombosis with increased risk of pregnancy loss. Increasing PAI-1 level had been shown to be an early feature of cardio-metabolic derangement in women with GDM. As well, GDM is regarded as an independent predictor for increasing PAI-1 levels compared to normal pregnancy. Taken together, GDM seems to be the causal factor in the increase of PAI-1 via induction of IR, hyperglycemia and hypertriglyceridemia. In conclusion, GDM triggers expression and release of PAI-1 which linked with GDM severity due to exaggerated pro-inflammatory and inflammatory cytokines with the development of IR. High PAI-1 levels in GDM may induce hypofibrinolysis and thrombotic complications.

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“…[ 8 ] Into the bargain, reduction of circulating free fatty acids improves insulin secretion and pancreatic β-cells function in obese T2DM patients. [ 9 ]…”

Section: Introductionmentioning

confidence: 99%